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There was nothing new in the authors' finding but their reports support what is already known, hence it is a useful contribution.
I am experienced in this area of science having published a similar study and other works in HIV/AIDS patients.
#2. The conclusions concerning the risk of coronary heart disease based on just serum lipid profile alone needs more clarification. The trend in the reduction in LDL and HDL in the subjects were not highlighted enough to know the ratio of LDL to HDL or total cholesterol to HDL, which are more important than taking the parameters individually. The highest serum mean triglyceride levels was less than 2mmols/L, which does not pose any risk at that level for coronary heart disease. By the current WHO guidelines on HAART, drugs are now commenced at a CD4 of 350cells/MicroL, so in effect patient on follow up may not have their triglyceride levels that high before they commence HAART, because triglyceride correlated negatively with CD4 count.
With advent of foreign partners funding the supply of HAART to resource constrained set up at very highly affordable or freely, the emphasis should be what obtains in lipid profiling in the era of HAART.
#3. May be in Ghana, definitely not in the Western World or some parts of subSaharan Africa, like Nigeria.
#9.the table on Pearsons correlation should be read easily horizontally and vertically for the parameters, it seems this is not so.
#11. The risk should be associated clinical risk factors.
Trained HIV-AIDS clinician with close to ten years experience. Worked with Family Health International as partners and USAID as resource person in Nigeria.
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