Submited on: 12 Oct 2010 08:29:27 PM GMT
Published on: 13 Oct 2010 11:01:16 AM GMT
 
The title is adequate.
Posted by Dr. Taofeeq Oduola on 15 Feb 2011 07:53:32 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? No
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? No
  • Other Comments:

    There was nothing new in the authors' finding but their reports support what is already known, hence it is a useful contribution.

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    Oduola T, Akinbolade AA,Oladokun LA, Adeosun OG.Ipadeola TI. Lipids profile in people living with HIV/AIDS on ARV therapy in an urban Centre of Osun State, Nigeria. World J.Med Sci.4(1):18-21,2009.
  • Experience and credentials in the specific area of science:

    I am experienced in this area of science having published a similar study and other works in HIV/AIDS patients.

  • How to cite:  Oduola T .The title is adequate.[Review of the article 'Serum Lipid Profiling In Highly Active Antiretroviral Therapy-naive HIV Positive Patients In Ghana; Any Potential Risk? ' by Quaye L].WebmedCentral 2010;2(2):WMCRW00475
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Suggestions taken in good faith. They would be effected. Thanks
Responded by Dr. Christian Obirikorang on 16 Feb 2011 10:16:24 AM

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Partly
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? No
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    #2. The conclusions concerning the risk of coronary heart disease based on just serum lipid profile alone needs more clarification. The trend in the reduction in LDL and HDL in the subjects were not highlighted enough to know the ratio of LDL to HDL or total cholesterol to HDL, which are more important than taking the parameters individually. The highest serum mean triglyceride levels was less than 2mmols/L, which does not pose any risk at that level for coronary heart disease. By the current WHO guidelines on HAART, drugs are now commenced at a CD4 of 350cells/MicroL, so in effect patient on follow up may not have their triglyceride levels that high before they commence HAART, because triglyceride correlated negatively with CD4 count. 

    With advent of foreign partners funding the supply of HAART to resource constrained set up at very highly affordable or freely, the emphasis should be what obtains in lipid profiling in the era of HAART.

    #3. May be in Ghana, definitely not in the Western World or some parts of subSaharan Africa, like Nigeria.

      #9.the table on Pearsons correlation should be read easily horizontally and vertically for the parameters, it seems this is not so.

    #11. The risk should be associated clinical risk factors.

  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    None
  • Experience and credentials in the specific area of science:

    Trained HIV-AIDS clinician with close to ten years experience. Worked with Family Health International as partners and USAID as resource person in Nigeria.

  • How to cite:  Imarhiagbe F .Serum lipid profiling in highly active antiretroviral therapy-naive HIV positive patients in Ghana; any potential risk?[Review of the article 'Serum Lipid Profiling In Highly Active Antiretroviral Therapy-naive HIV Positive Patients In Ghana; Any Potential Risk? ' by Quaye L].WebmedCentral 2010;2(1):WMCRW00396
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MINOR CORRECTIONS
Posted by Ms. Nguemaïm N Flore on 01 Nov 2010 07:54:39 AM GMT

  • Other Comments: 1. The authors did not mention the types of method they used to measure the serum lipid level and CD4 count in the abstract section, except CLDL. 2. The reference in the text in some parts is not well presented for example: Shor-Posner et al., (1993) [12] Stampfer et al., (1996) [22] Grunfeld et al (1996) [8] I think the reference aught to be written as Shor-Posner et al. [12] Stampfer et al. [22] Grunfeld et al. [8] or Shor-Posner et al. ??????.[12] at the end of the sentence. 3. The authors have to standardize the presented reference in the text. Example: Shor-Posner et al., (1993) Grunfeld et al (1991) On the second reference, I neither saw a full stop nor a semi-colon before the year of the publication. 4. The authors have to present all the references as shown by the Guidelines of the Journal. See the reference 20, 21, 22 for example which have different presentations compared to others. 5. The techniques mentioned in the methods section is appropriate but not well described specifically in this part which is very important to know how the authors proceeded to have their results. 6. The authors did not give the exclusion criteria or the eligible criteria of the patients. 7. The authors did not mention the number of patients examined and the number of patients excluded. 8. The authors did not give the total enrolment of the controls and subjects in table 1. There are no percentages in the first colon concerning the control as presented in other colons of the same table. Conclusion: The manuscript gave the opportunity to know about the potential risk due to the lipid abnormalities in Ghanaians HIV na?ves patients. This is a health domain actuality. The authors present the importance of measuring the lipid profile of the HIV patients before the beginning of HIV therapy. The plan of the manuscript respects the guidelines recommended by the Journal. The references given in the reference section are well presented but not uniform. The methods and the results are well presented as well as the tables except table 1. The conclusion shows the importance of lipid control in medical care of Ghanaians HIV positive naive patients. The research is original, and i think that after the authors take in consideration these minor corrections, the manuscript will be in best form to be published. I congratulate the authors for the work done.
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:
    None
  • How to cite:  Flore N N.MINOR CORRECTIONS[Review of the article 'Serum Lipid Profiling In Highly Active Antiretroviral Therapy-naive HIV Positive Patients In Ghana; Any Potential Risk? ' by Quaye L].WebmedCentral 2010;1(11):WMCRW00100
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the minor corrections have been addressed. Thank you
Responded by Dr. Christian Obirikorang on 16 Feb 2011 10:41:24 AM