Submited on: 20 Oct 2011 03:07:42 AM GMT
Published on: 20 Oct 2011 02:14:54 PM GMT
 

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Clinical trials on single subjects are helpful before actually proceeding with case control studies on a larger samples. In relation to the present study, I suggest the following:

    1. A placebo drug could have been tried on an age matched control after assessing the fitness.

    2. Double blinding would have erradicated bias.

    3. The placebo could have been tried on the same case subject between the phases, with wash out periods between each phase.

    4. A case control study with larger sample size is welcome as the results are promising.

       The reviews are posted to strenthen the article and the study. 

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    none.

  • How to cite:  Rao K .review of revised version of -Coenzyme Q-10 Effects Endurance Performance - A Case Study [Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001072
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Dr. Rao, Thank you for presenting an excellent review with comments I agree completely. I will add the following thoughts that I have been reluctant to share until now, since I conclude that your review best states changes that will improve further study in this arenae. ADDENDUM FOR REVIEWERS Prior to the test trials, I prepared by reading the science written by the scientists working for both manufacturers. Each argued with each other to a stalemate. The Kaneka rationale matched some science-method reports connected with aging, while Best Formulations rationale stated that Ubiqiunone was more stable than Ubiquinol, and that stability for the exogenous form favored Ubiquinone and that they each were involved interchangeably and needed for trading off hydrogen molecules during the energy cycle. Both manufacturers stated that their product maintained steady state blood serum levels better than the other. Who was I to believe? I therefore hypothesized that if I took 400mg/day of either Ubiquinol or Ubiquinone during 90-days of timed runs over a common course that I had trained on to attain familiarity and fitness, that one or both versions would exceed base performance, determined after a 14-day washout period (half-life of CoQ10 is 36-72 hours) in a resting subject) and since I was training during the washout period 60-90 minutes average daily, the washout 14-days would easily washout all previously dosed CoQ10. The methods section of this paper did not detail that prior to each timed trial, resting heart rate the day prior to each test was between 51-56 bpm. (resting low HR =51bpm). If the resting heart rate was not within this range, recovery being incomplete, no timed run performance was determined. Max Heart Rate for a 71-y male based on the Karvonnen formula, is 149 bpm. Heart rate at the end of each timed performance ranged between 156-164 (104%-110% max heart rate).This is a clear indication that on the day a timed performance was tested, the subject was adequately rested and at finish had expended himself to the full. I have no connection with or competing interest in either form of product and am persuaded that bias was absent. Nevertheless, double blind and placebo would and should be employed to address the issue of bias. The first paper proceeding this one's title was changed from "Case Study" to "Case Report." Physicians write Case Reports regularly reporting an anomaly in detail based on their objective and many times subjective observations, without placebo, nocebo, or blinded protocol structure. A "Case Report" several of the reviewers stated precedes or justifies tightening double-blinded and placebo protocols to control for the sake of responsibly collecting data for determining conclusions. This "Case Report" is an open label experiment in which the author was the subject who strictly maintained the same low fat whole plant food dietary menu during the year prior to and the year of these 21-timed performances collected during this 194-day period. In my view, this "Case Report," though inconclusive as based on sound science method principles, presents specific information observed and reported by an one elderly fit 71-year subject for recruiting a larger contingent of adult male and female fit subjects to measure and evaluate the effects of Ubiquinone or Ubiquinol in double-blind-placebo on timed endurance performance. The question asked is, does this "Case Report" merit a larger study with proper controls to ensure reliability? The answer is absolutely, yes! Respectfully submitted, Bill Misner PhD
Responded by Dr. Bill Misner on 30 Oct 2011 04:24:22 PM

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Partly
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? No
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:
    • I believe that the author should increase control and case group subjects. Despite being a case report the aim of  this paper is greater than this. 

    • The  discussion and conclusion need to be more detailed.

     

  • Competing interests:
    no
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I am a professor of medicine with a nutritional teaching  backgound

  • How to cite:  Bedin V .Coenzyme Q-10 effects endurance performance - A case study[Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001044
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Partly
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? No
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Reference section has been added; references are appropriate for the article.

     

    Regarding the statement in the abstract "For these results for one subject male 71-years to be conclusive the trend should further confirmed or denied by examining dose and performances associated from a larger contingent of male and female runners over age 40", wording implies that a trend was observed. It is not appropriate to refer to results from a single subject as a "trend."

     

    The information preceding the Methods section would be better titled "Introduction."

     

    There should be a "Discussion" section following the results. It would be useful to include some of the comments that have been included in the author's responses to the reviews.

     

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    Herchline T .Coenzyme Q-10 and Endurance Performance[Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001028
  • Experience and credentials in the specific area of science:

    Experienced runner (have completed > 30 marathons)

  • How to cite:  Herchline T .Coenzyme Q-10 and Endurance Performance - Updated Review[Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001043
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    The paper is well written. The study is well planned. Addition of little more discussions would make this paper still better.

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I was also involved in clinical trials and case studies concerned to novel drug delivery systems.

  • How to cite:  Kulkarni G T.Coenzyme Q-10 Effects Endurance Performance - A Case Study[Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001037
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Dr. Kulkami, Thank you for your review and comments. Bill Misner
Responded by Dr. Bill Misner on 08 Dec 2012 05:44:50 PM

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Partly
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? No
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    It is difficult to draw conclusions from the way this data data was presented. The statistical tests carried out to determine significance were not stated. The use of percentages alone can be very deceptive in arriving at scientific conclusions. And the discussions should come after the results.

  • Competing interests:
    NONE
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I have geriatric patients in the intensive care on ubiquinone therapy from their physician. The marginal benefit of this drug is still not very clear

  • How to cite:  Ajuzieogu O V.Coenzyme Q-10 Effects Endurance Performance-A Case Study[Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001036
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? No
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? No
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    author must increase control and case group subjects. without increasing subjects author can not reach at any conclusion as happen in this study. discussion and conclusion need to described in detail.

  • Competing interests:
    no
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    experienced in muscular movements and physiology

  • How to cite:  Singh B P.Coenzyme Q-10 Effects Endurance Performance - A Case Study [Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001032
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Coenzyme Q-10 and Endurance Performance
Posted by Dr. Thomas Herchline on 20 Oct 2011 11:38:02 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? No
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? No
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? No
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    This is a trial with N=1, a single subject. No conclusions can be made from the data presented.

     

    There are references within the body of the article, but no section at the end of the paper for listed references.

     

    There are conclusions presented in the abstract, but no section for conclusions following the results. Further, the section labeled "Discussion" is actually an introduction.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    Experienced runner (have completed > 30 marathons)

  • How to cite:  Herchline T .Coenzyme Q-10 and Endurance Performance[Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001028
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? No
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? No
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    The data presented do not support the conclusions.  It would have been useful to see the actual times for each run in each of the three categories.  Running times should have been presented as the mean and SD of each category, and not as the best time in each category.

    the structure of a standard paper contains the Discussion at the end, not prior to Methods and Results.

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    Eliakim A, Nemet D and Shenkman L. Serum enzyme activities following long-distance running: comparison between Ethiopian and white athletes. Isr. J. Med. Sci. 1995; 31: 657-659.
  • Experience and credentials in the specific area of science:

    Professsor of medicine, specialist in internal medicine and endocrinology and metabolism

  • How to cite:  Shenkman L .Coenzyme Q-10 Effects Endurance Performance - A Case Study[Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001026
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Review of case study
Posted by Mr. Michael Zanovec on 20 Oct 2011 06:15:48 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Partly
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    This case study is well documented and the manuscript is well-written and provides a thorough introduction and background. Suggest adding a few comments after the Results section to conclude and discuss implications and suggestions.

  • Competing interests:
    No competing intersts to declare.
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    Daray LA, Henagan TM, Zanovec M, Earnest CP, Johnson LG, Winchester J, Tuuri G, Stewart LK. Endurance and resistance training lowers C-reactive protein in young, healthy females. Applied Physiology, Nutrition, and Metabolism, 2011, 36:660-670, 10.1139/h11-077.
  • Experience and credentials in the specific area of science:

    Background in kinesiology and nutrition and former marathon runner.

  • How to cite:  Zanovec M .Review of case study[Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001025
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Micahel Zanovec, I hope for your review of the revised version entitled, Coenzyme Q-10 Effects Endurance Performance - A Case Report Bill Misner PhD
Responded by Dr. Bill Misner on 29 Oct 2011 02:36:03 AM