Open Access Biomedical Publisher Using Post Publication Peer Review
need rearrengments of references
need in vivo study
open a new scope for antibacterial action of H2-blockers
interpretations of significant level should depend the p value
good new idea
informative and applicable
need i vivo study
rearrangment of references
i so appreciate this work
The paper is focused on the actual problem of searching of new antibacterial drugs that are no antibiotics. Author shows that the Famotidine, that is antihistamine receptor type 2 blocker, has significant antibacterial activity, specially against Escherichia coli. Unfortunately, this valuable finding is presented in unsatisfactory form, that give rise to many criticism, particularly:
1) The tables should be revised and show statistics, at least mean ± SD and P compared to negative controls, because each bacterial group is presented by several strains. Alternatively, every bacterial strain may be showed individually.
2) Acronyms in tables should be explained (Table 3: MIC?)
3) Unclear, what concentrations test compounds (cimetidine, ranitidine and famotidine) are contained in 100 ml (Section of Methods and Tables 2, 3).
4) All tables should be revised concerning mistakes and presented in more acceptable form.
5) Figure 1 should be presented in more acceptable form.
6) The all text need to revise on clarity, conciseness and correctness of language.
7) List of references should be presented in uniform manner and updated with articles 2008-2011.
Thus, the manuscript should be significantly revised and resubmitted.
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