Submited on: 18 Feb 2012 03:13:45 AM GMT
Published on: 18 Feb 2012 09:37:23 AM GMT
Comment on Ketamine-abuse-uropathy.
Posted by Prof. Kostis Gyftopoulos on 22 Feb 2012 01:20:00 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Partly
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? Yes
8 Is the quality of the diction satisfactory? No
9 Are the illustrations and tables necessary and acceptable? No
10 Are the references adequate and are they all necessary? No
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Ketamine-abuse uropathy is a rather newly recognized entity that begins to draw the attention of urologists in countries where recreational use of ketamine has become popular. Keeping in mind that ketamine users are increasing in numbers, a higher degree of alertness may be mandatory in the future when treating patients with "unexplained" LUTS and painful bladder symptoms. In this context the review by Venyo and Benatar would be more than welcome... However, there are several points that in my opinion prevent the reader from obtaining an overview of the subject. The presentation of the literature review is unnecessarily extensive and written in a "narrative" style that often distracts the reader's attention from the main points of interest. Moreover, extensive reference in details of history and lab tests for every patient described in published case reports is pointless. The main point for a comprehensive review is exactly to summarize findings and present key information based on the existing literature.

    I believe that a thorough review on ketamine-abuse -uropathy should address a few vital questions: Is there a causative role for ketamine in the "uropathy" described? What are the proposed mechanisms? Are there tissue or animal models to support the damaging theory? What are the typical (or less typical) symptoms that should alert a physician? What lab tests or examinations should be employed and why? Are there any treatment options available? Is cessation of ketamine use mandatory for these patients? I would like to invite the authors to improve their extensive review by abridging the literature review section and focus on answering the aforementioned questions in a way that is more reader-friendly.

    The following reference should also be taken into consideration: Recreational ketamine: from pleasure to pain. Wood et al. BJU Int. 2011 Jun;107(12):1881-4.

  • Competing interests:
  • Invited by the author to review this article? :
  • Have you previously published on this or a similar topic?:
  • References:
  • Experience and credentials in the specific area of science:

    Ass. Professor of Anatomy, Urologic Surgeon, Head of Urology Dept. in a private hospital and rehabilitation center. No particular experience with ketamine abuse.

  • How to cite:  Gyftopoulos K .Comment on Ketamine-abuse-uropathy.[Review of the article 'A Review of the Literature on Ketamine-Abuse-Uropathy ' by Benatar B].WebmedCentral 2012;3(2):WMCRW001516
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