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Introduction to Cofilin and its Regulation of Actin Dynamics
By Mr. Kuen Yeow Chin
Submited on: 14 Sep 2010 10:06:05 PM GMT
Published on: 14 Sep 2010 10:35:20 PM GMT
 
Introduction to Cofilin and its Regulation of Actin Dynamics
Posted by Dr. William J Maloney on 14 Feb 2014 05:37:17 PM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    The purpose of this paper is to discuss the several important roles cofilin plays in the regulation of actin dynamics and cell motility.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    Yes


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    No


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes- this would be a great seminar at a medical school.


  • Other Comments:

    Actin is the most abundant protein in eukaryotic cells.  Cofilin is a part of a family of small actin binding proteins that is present in all eukaryotic cells.  The author states that there is promising therapeutic potential as infertility, Alzheimer's disease, ischemic kidney disease, and cancer have been suggested to be associated with the altered production, regulation or localization of cofilin.

  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    Clinical associate professor

  • How to cite:  Maloney W J.Introduction to Cofilin and its Regulation of Actin Dynamics[Review of the article 'Introduction to Cofilin and its Regulation of Actin Dynamics ' by Chin K].WebmedCentral 2012;5(2):WMCRW002990
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Review of Introduction to cofilin and its regualtion of actin dynamics
Posted by Dr. Michael J Williams on 29 Feb 2012 03:49:54 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? Yes
8 Is the quality of the diction satisfactory? No
9 Are the illustrations and tables necessary and acceptable? No
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    This review was an introduction of cofilin, with a biased towards the questions around cofilin function during actin formation. Overall it was a good, although superficial, introduction in to the field. What was lacking was a good figure showing the possible different functions of colfilin, to help explain the dichotomy of functions and the questions surrounding what really is cofilin doing during lamellipodia formation. Also, there were many grammatical and typing errors.

  • Competing interests:
    I have no competing interests to declare.
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    None
  • Experience and credentials in the specific area of science:

    I have substantial experience studying the roles of Rho GTPases in the regulation of actin formation.

  • How to cite:  Williams M J.Review of Introduction to cofilin and its regualtion of actin dynamics[Review of the article 'Introduction to Cofilin and its Regulation of Actin Dynamics ' by Chin K].WebmedCentral 2012;3(2):WMCRW001531
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