Submited on: 12 Nov 2010 12:20:19 PM GMT
Published on: 13 Nov 2010 05:30:42 PM GMT
 

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    This article describes the introduction of image-guided intensity-modulated stereotactic radiotherapy into a radiotherapy department for treatment of patients with metastatic and locally advanced cancers. It describes the characteristics and technical treatment aspects of the first 34 patients.

    Patients with complicated metastatic or locally advanced disease can be treated with image-guided intensity-modulated stereotactic radiotherapy, because treatment with conventional approaches would not allow delivery of adequate radiation doses to the planning target volume in combination of sparing of normal tissues. The dose distributions achieved a much more homogeneous dose to the planning target volume and minimize dose to the adjacent normal tissues.

     

    Samant et al. also reported a clinical experience of using image-guided intensity-modulated radiotherapy (IG-IMRT) for treatment of patients with metastatic and locally advanced cancers. With an IG-IMRT approach, relatively small margins around the areas of tumor can be used, because patients will be re-imaged for verification of position and tumor location before each treatment.

     

    In the clinical aspect, the local control rate reported by the manuscript is 33/34(97.1%). The result is close to the control rate described in the review series of

    Sahgal et al.

     

    In this article, the group mean errors of Axesse in combination with a HexaPOD robotic treatment table were ≦ 1 mm (translational) and ≦ 1° (rotational). The results are similar to that of Synergy S in combination with a HexaPOD robotic treatment table and Cyberknife.

     

    Image-guided intensity-modulated stereotactic radiotherapy appears to be a safe and effective treatment option in the multidisciplinary management of metastatic and locally advanced cancers.

     

    The disadvantage of this article includes the limited number of patients, the heterogeneity of the patient cohort, the limited follow-up and the retrospective nature of the analysis. Prospective trials concerning standards on treatment parameters, and methods to evaluate outcomes are necessary.

  • Competing interests:
    no
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    Four years of teaching experiences in the department of radiology in a medical university and another 5 years of research experimences focusing on dosimetry, medicine physics, and radiotherapy technology.

  • How to cite:  Hsu F .The Role Of Image Guided And Intensity Modulated Stereotactic Radiotherapy For Patients With Metastatic And Locally Advanced Cancers [Review of the article 'The Role Of Image Guided And Intensity Modulated Stereotactic Radiotherapy For Patients With Metastatic And Locally Advanced Cancers ' by Huang C].WebmedCentral 2010;1(12):WMCRW00204
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    This article mentioned that the treatment of stereotactic radiotherapy was using image-guided intensity modulated radiation therapy technique and using 6-axis automatic tracking bed for position error correction. At the present time, most of the radiation therapy only use three axial position correction (XYZ) technique to make the error within 2mm and angle error within 1 °, but the 6-axis treatment beds has increased the precision by correction of pitch, yaw, roll, of the location to make the error <1mm and <1 °. The treatment can be more accurate.

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:
    I had surpass 14 year experience in the medicine physics and the radiotherapy technology
  • How to cite:  Chung C .The Role Of Image Guided And Intensity Modulated Stereotactic Radiotherapy For Patients With Metastatic And Locally Advanced Cancers [Review of the article 'The Role Of Image Guided And Intensity Modulated Stereotactic Radiotherapy For Patients With Metastatic And Locally Advanced Cancers ' by Huang C].WebmedCentral 2010;1(11):WMCRW00166
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Report abuse
 

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    In recent years, radiation therapy has advanced to the image guidance (IGRT) treatment model. This article mentioned that using CBCT and HexaPOD 6-axis automatic bed for immediate treatment location correction each time before treatments and the error of <1mm could be achieved. The technique with good precision is ideal for patients with head and neck cancer and for body stereotactic treatments to avoid high dose to the vital organs. To maintain the quality of such a precise radiation treatment, both the quality assurance of radiation treatment machines and training of professional radiologists, physicists, engineers are very important. It should be in accordance with the Atomic Energy Commission of the provisions of the medical exposure quality assurance to get such a good radiation treatment quality.

  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I had 20 year experience in the radiotherapy domain

  • How to cite:  Huang S .The Role Of Image Guided And Intensity Modulated Stereotactic Radiotherapy For Patients With Metastatic And Locally Advanced Cancers [Review of the article 'The Role Of Image Guided And Intensity Modulated Stereotactic Radiotherapy For Patients With Metastatic And Locally Advanced Cancers ' by Huang C].WebmedCentral 2010;1(11):WMCRW00165
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