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This paper claims a new hypothesis (AND gate) involving Claustral-Cortical-Claustral connections, which unifies sensory-consciousness
There are no results or evidence to support the claims
No protocol has been provided.
No experimental methodology has been described. Therefore the question of them being reproduced does not arise.
This work needs to validated by animal and / or human subject studies.
Not an outstanding paper. In its present form it cannot be presented in any seminar. I would not use it in my university lecture till it is restructured considerably.
1. This is basically a review of literature on the possible mechanisms of claustral functioning. Therefore it should be presented as such. 2. Only a theoretical hypothesis has been proposed, based on previous studies. This requires to be validated by appropriate experients, results and conclusions3. The size of this paper needs to be reduced to about one-third its present size. Ten PDF pages can be condensed to about 3 pages.4. Too many quotations from previous studies are scattered everywhere. It should be more structured, with precise headings, as in a review of literature.5. The occasional spelling or typographical error should be corrected; e.g. model instead of module, retinotopic instead of retinotropic
I have performed extensive dissections on cadaver human brains. See the following URL: http://www.webmedcentral.com/View_video/244 and http://www.webmedcentral.com/View_video/245
This paper represents a significant step forwards in our understanding of such an important, yet little understood, structure shedding new light on how the brain integrates sensory inputs. I believe this is a key paper on the subject of the claustrum.
The hypothesised mechanisms of claustral activity and how it interacts with higher cortical centres although has been suggested previously has not been explained in such a logical and detailed manner previously.
Although the paper does not stem evidence from an experiment devised to elucidate tthe functional connectivities and underlying mechanisms within the claustrum, it provides a very logical argument to support the proposed hypotheses stemming from other key works within the field.
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As noted previously and conceded to by the authors themselves the hypotheses proposed remain to be verified or otherwise refuted by direct experimentation.
This paper Perot my knowledge provides the most detailed and logical explanation of how the claustrum functions.
It is my humble opinion that the cortico-claustro-cortical connections represent spirals rather than cycles. There is evidence of these spirals existing elsewhere in the CNS such as seen in the cortical connections with thepascal ganglia. This would allow for an integrating area to receive input from the sensory modalities as well as from the claustrum carrying the temporal binding signature.
MSc Cinical Neuroscience
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