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The author described a case report of two sisters suffered from Darier’s disease complicated with persistent infection of HSV. The author used Tzanck test for rapid diagnosis that was confirmed latter by neutralization test that confirm the HSV infection. The diseased case showed slow but successful response to the treatment with oral acyclovir as indicated clinically and weekly monitoring using quick Tzanck test.
The claims are not novel
No, the author did not provide his methodology in a separate section. It is recommended to add a methodology section to the manuscript.
Abstract:The author should remove the first statement or replace it by more informative one about the disease description. It is better to organize the abstract into background, methods, results and conclusions.Introduction:The introduction should state purpose of the work. A summary of the literature to indicate why this study was necessary and what it aimed to contribute to the field. Accordingly the author should rewrite the introduction keeping these issues in mind and should refer the information used in the introduction with references. It is better to add some information about the disease frequency in Japan if such data is available. Introduction should contain cited references.Cases:Merge the two cases in one case instead of case 1 and case 2Comments section1. It is better to replace the word comments by discussion.2. In the comment, the author mentioned that the chronic, unremitting burden on patients due to these complications was revealed in a clinical review of 163 patients by Burge in 1992.7. The reference No 7 is not Burge and should be replaced by Burge and Wilkerson 1992. Please put the reference number between brackets.3. The author mention the modified preservative Giemsa stain as described by Shino 1993. Please remove this statement and you could describe how you made your test in the item methodology. When you cite a reference, please do not precede the author name by a title [Dr., Mr.,…etc].It is not necessary to mention the stability duration of the stain in the discussion section because you described a case report and you did not modify this test.4. The author mentioned” These 2 cases demonstrate that DD may be complicated by persistent HSV infection rather than episodic infection as previously described. [Please add reference ]”5. The author mentioned ‘’Decreased areas of skin lesions may represent decreased she dding [remove the space to be shedding]of the HSV, which is very important in controlling infectious disease [add reference]References:The authors used references from 1970-2004, I wonder if they be able to add recent ones, I found recent publications till 2012 in the pubMed. The authors should cite references within the body of the manuscript between brackets.The first reference, the author wrote No. 1 twice.1. Craddock N, Dawson E, Burge S, Parfitt L, Mant B, Roberts Q, et al. The gene for Darier’s disease maps to chromosome 12q23-q24.1. Hum Mol Genet. 1993;2:1941-1943.
For Journal manager:The figures appear only in the pdf version but not in the html version, I think that figures should appear in both version.DecisionAccepted after making the required changes.
I have 15 years experience in virology.
This is an interesting study to show the relationship between Darier's disease and Herpes Simplex Virus 1 infection.
Mol bio experiments should be added to the manuscript.
It's a good study
Mol bio experiments should have been added to the manuscript to established the facts.
Journal of Virology, 2009 PLoS Pathogens, 2009 PLoS One, 2011
1. The study claims to have observed partial remission of HSV infection in two cases upon a continuous therapy with oral acyclovir;
2. The author also claims that because there is a partial remission, there may be a decrease in shedding of the virus, whence it has implications in controlling the disease, with specific reference to Darier's Disease.
1. Leroy D et al. Acyclovir treatment ... Darier's Disease. Dermatologica, 1983; 167 (4): 212 - 216.
2. Parham et al. Disseminated Herpes simplex ... oral acyclovir. J Infect, 1985; 10 (1): 77 - 78. However, the condition for which the present author claims partial remission may be novel.
To a certain extent, the claims seem to have been properly placed in the context of the previous literature. However, a better literature survey would have added credence to the report.
Pre-treatment and post-treatment fiugres/pictures would have added more credibility to the author's claims.
Since this is a case report, exhaustive details of both protocols & methodology may not be essential.
As has been mentioned earlier, pre-treatment, and post-treatment pictures of the disease condition would have added credence. This is essential because the article is a case report and protcols & methodology may not be described in detail.
Too early, since this is a case report.
1. Studies on shedding of viruses is extremely important from a transmission perspective. Hence, this article/case report assumes importance in the field of virology;
2. However, there are certain drawbacks noted in this case report by Dr. Lily Hsiao: Nowhere in the article/report, except for the title, is it indicated that Case 1 and Case 2 are related and belong to the same family. This is important because Darier's Disease is indicated to be inherited.
3. A note on whether the patients were sexually active at the time of treatment is also important as HSV is also sexually transmitted.
4. The article fails to indicate whether the infecting type is HSV-1 or HSV-2.
Virology/Immunology/Immunodiagnostics of Hepatitis C virus (HCV)
It's an interesting study to show the severity of Darier's Disease followed by Herpes Simples Virus 1 infection.
Yes, it shows the correleation between Darier's Disease and Herpes infections and showed the methods of detection of this disease.
Molecular Biology studies should have been incorporated
This is good one
It would have been good if authors could have done some recent molecular biology studies to established the facts in terms of severity of disease.
Journal of Virology, 2009 PloS Pathogens, 2009 PloS One, 2011
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