Submited on: 30 Dec 2011 09:26:57 PM GMT
Published on: 31 Dec 2011 10:33:36 AM GMT
 
Multiple Cafe Au lait Spots
Posted by Prof. Jayendra R Gohil on 29 Jul 2012 10:32:43 AM GMT

  • What are the main claims of the paper and how important are they?

    That Multiple Cafe Au lait Spots can occur without serious disease. 


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    The claims are not novel.


  • Are the claims properly placed in the context of the previous literature?

    No


  • Do the results support the claims? If not, what other evidence is required?

    The discussion is weak. Does not mention size and site of spots except saying 'multiple in a 5 yr boy'. Axillary spots or freckles are must in NF-1; that has not been mentioned whether axillary freckles are present or not ?. There are no references. Complication of CNS - brain or spine may occur in later life so it is too early to say that no disease is present without imaging studies and waiting for follow-up.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    NA


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    NA


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    NA


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    No


  • Other Comments:

    No

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    No
  • Experience and credentials in the specific area of science:

    Pediatrics faculty 20 yrs.

  • How to cite:  Gohil J R.Multiple Cafe Au lait Spots[Review of the article 'Multiple Cafe Au lait Spots. ' by Karthick A].WebmedCentral 2012;3(7):WMCRW002145
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