Open Access Biomedical Publisher Using Post Publication Peer Review
This paper provides in vitro anti-cancer studies of a series of compounds derived from natural herb that is is commonly used in the Kempo medicine. The study was done in a detail manner focussing primarily on the anti-telomerase activity.The paper could be improved in a number of ways. 1) The sourcing of the materials should be more clearly identified. It is common knowledge that herbs tend to vary in their phytochemical conditions based on their variety and planting conditions.
The IC50 values of each compound should be tabulated in a table. The IC50 values can provide better insight into the anticancer potential of the compounds. The author did mention that the antiproliferative activity was mild (unpublished data) such indication would have given a clue that most likely the compounds will not target the toposiomerase activity. Compounds that targets topoisomerase enzymes tend to have strong cytotoxic response.
Overall, the paper provides a good insight into the anti-cancer activity of these compounds. However, to stress on cancer preventative properties , one must also look at other pathways such as angiogenesis. Many natural products appear to confer their anti cancer activity via this pathway instead of the cytotoxic pathway.
I work on cancer drug discovery from natural products.
All site content, except where otherwise noted, is licensed under a
Creative Commons Attribution License