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Antithrombin Hanoi: Arg 393 to His Missense Point Mutation in Antithrombin Gene and Cancer

By Dr. Khue V Nguyen

Submited on: 21 Sep 2012 08:59:58 PM GMT

Published on: 26 Sep 2012 01:46:53 PM GMT

Arg 393 to his Missense Point Mutation in Antithrombin Gene and Cancer

Posted by Prof. Valcinir Bedin on 04 Oct 2012 12:55:24 AM GMT

What are the main claims of the paper and how important are they?
The main claims were to ptove that there was a gene in the case reported and the importance is that it is a novel approaching to the linkage of kidney cancer and the gene.
Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.
Yes
Are the claims properly placed in the context of the previous literature?

Yes, the claims ae placed properly.
Do the results support the claims? If not, what other evidence is required?

Yes
If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

The protocol to ths ind of paper was followe in the proper way
Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

The methodology was clear and revealing.
Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

More cases would improve its aims
Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?
Yes, its outstandng for is novelty and for the papers it could generates.
Other Comments:
No
Competing interests:
No
Invited by the author to review this article? :
No
Have you previously published on this or a similar topic?:
No
References:
Experience and credentials in the specific area of science:

I have been studying skin cancers for the last 30 years.
How to cite: Bedin V .Arg 393 to his Missense Point Mutation in Antithrombin Gene and Cancer[Review of the article 'Antithrombin Hanoi: Arg 393 to His Missense Point Mutation in Antithrombin Gene and Cancer ' by Nguyen K].WebmedCentral 2012;3(10):WMCRW002278

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