Submited on: 05 Sep 2010 07:15:02 AM GMT
Published on: 05 Sep 2010 07:24:50 AM GMT
 

  • What are the main claims of the paper and how important are they?

    The authors propose that the anti-oxidant properties of Coenzyme Q may help diabetic neuropathy by reducing oxidative stress.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    No.


  • Are the claims properly placed in the context of the previous literature?

    Yes.


  • Do the results support the claims? If not, what other evidence is required?

    Yes.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    N/A.


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    N/A


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    N/A


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    The paper gives a plausible hypothesis regarding the treatment of diabetic neuropathy using the anti-oxidant properties of Coenzyme Q.


  • Other Comments:

    There are some grammatical concerns, but none the less the authors provide an interesting review on the literature.  It's certainly plausible that ongoing mitochondrial oxidative stress may contribute to lipid peroxidation, etc. and cellular breakdown.  The idea is also supported by the literature regarding the benefint of alpha-lipoic acid (please see:  A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. Eur J Endocrinol. 2012 Oct;167(4):465-71).  This area certainly needs more research.  What is the dose and frequency that shoud be used?  Should we be giving our patient anti-oxidant cocktails, with Coenzyme Q being only one component?  Of note, the Parkinson's disease literature regarding the role of Coenzyme Q in mitochondral health and improves outcome is encouraging (please see:  Cochrane Database Syst Rev. 2012 May 16;5:CD008150), but more studies on both fronts are needed before any conclusive recommendations can be made.

  • Competing interests:
    No.
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    General neurology

  • How to cite:  Rison R A.Diabetic Neuropathy, Mitochondria, and Coenzyme Q[Review of the article 'Diabetic Neuropathy And The Mitochondria,Can Coenzyme Q Be Of Help ' by Arora P].WebmedCentral 2012;3(11):WMCRW002363
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    The author's rationale is reliable and sound.

    Key antioxidants to neutralize ROS are covered in detail.

     

    Exercise and age may tax the mitochondria life span and raise ROS levels, with modest exercise rebound mechanisms reducing ROS post-exercise.

     

    The author presents an excellent idea for reducing the degenerative processes observed in diabetic neuropathy. Reduced Ubiquinone may be a treatment protocol that larger studies conducted to may determine favorable effects and dose.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    Misner B., Does Glutathione Enhance Exercise Performance? - A Case Study. The Townsend Letter For Doctors & Patients. July 2003:66. http://www.townsendletter.com/ Misner B . Coenzyme Q-10 Effects Endurance Runner's Performance - A Case Report . WebmedCentral ALTERNATIVE MEDICINE 2011;2(11):WMC002437 http://www.webmedcentral.com/article_view/2437
  • Experience and credentials in the specific area of science:

    Misner B . Coenzyme Q-10 Effects Endurance Runner's Performance - A Case Report . WebmedCentral ALTERNATIVE MEDICINE 2011;2(11):WMC002437 http://www.webmedcentral.com/article_view/2437


  • How to cite:  Misner B .Diabetic Neuropathy Mitochndria Required Antioxidant-Need for Coenzyme Q10[Review of the article 'Diabetic Neuropathy And The Mitochondria,Can Coenzyme Q Be Of Help ' by Arora P].WebmedCentral 2012;2(11):WMCRW001118
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  • Other Comments: The manuscript is easy to follow and it is well written. It is interesting and of general interest.
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:
    One Year
  • How to cite:  Sharma J .Diabetic neuropathy and the mitochondria: Can Coenzume Q be of help?[Review of the article 'Diabetic Neuropathy And The Mitochondria,Can Coenzyme Q Be Of Help ' by Arora P].WebmedCentral 2012;1(10):WMCRW0052
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