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What are the main claims of the paper and how important are they?
Avan flu is an important zoonotic disease of immense public health importance.
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Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.
Yes
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Are the claims properly placed in the context of the previous literature?
Yes
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Do the results support the claims? If not, what other evidence is required?
Review is well justified.
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If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?
No comments.
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Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?
Yes
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Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?
Some recent information and literature may improve and strengthen the content of the said review.
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Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?
The review has been well represented.
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Other Comments:
Article is worthy for consultation by the experts and researchers in the concerned field.
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Competing interests:
No
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
Yes
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References:
1. Mukhopadhayay, S.K.; Patra, N.C., Ganguly, S. 2011. Molecular characterization of avian influenza virus isolates from Indian poultry. Proceedings of the 99th Session of the Indian Science Congress [Full paper in Animal, Veterinary and Fishery Sciences section], V-O-10: pp.108; V-P-16: pp.124. 2) Ganguly, S., Prasad, A. 2010. Swine Influenza – Its Different Perspectives with Highlight On The 2009 Outbreak. Livest. Line, 3(10): 30-34.
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Experience and credentials in the specific area of science:
None - How to cite: Anonymous.Avian Flu: A possible Pandemic Threat [Review of the article 'Avian Flu: A possible pandemic threat ' by Awadalla H].WebmedCentral 2012;3(11):WMCRW002334
Responded by Dr. Hala Awadalla on 09 Feb 2013 09:54:28 PM
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An overlook on emergence of flu virus. Author has putforth the evolution of various pandemics of past. And this is very important if we have to think about predicting a posssible threat. An understanding of emergence of influenza virus, though is a difficult one. We have always attempted to study the pandemics, tried to predict and looked for a protective vaccine
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Yes. any reader can come to a clear understanding of flu virus
Good article. As influenza virus has many serotypes based on the haemagglutinin(1-15) and Neuraminidase(N1-9), and that it has multiple host range (human, pig, fowl/birds, seals) and most have a close contact with human, the transmission chains remain open. The ability of virus to change antigen (ANTIGENIC DRIFT AND SHIFT) and most importantly the virus from different hosts can mix resulting in a different serotype that may be more pathogenic makes this virus a possible threat in producing a pandemic
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Often updating on flu virus, teaching medical graduates, involving in diagnosis
Responded by Dr. Hala Awadalla on 09 Feb 2013 09:54:57 PM