Submited on: 23 Nov 2012 09:56:19 AM GMT
Published on: 23 Nov 2012 04:35:17 PM GMT
 

  • What are the main claims of the paper and how important are they?

    There is an issue with antibiotic resisitance in ESBL producing bacteria. Urinary tract infections are very common and are aq source of this type of resistant bacteria...specifically E.Coli being the source discussed here. Yes, antibiotic resisitance is an issue that must be addressed.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    These claims are novel in that they provide a clear depiction that there is a significant subset of pateints exhibiting resistance to standard antibiotics in this region...thus presetning a real public health issue.


  • Are the claims properly placed in the context of the previous literature?

    Further explanantion as to the background behind ESBL bacteria and their significance would be appreciated. What specifically are the precautions that are mentioned in the article pertaining to "controlling' this issue. Is this a world-wide issue or soemthing that is only pertinant to this region of the world?


  • Do the results support the claims? If not, what other evidence is required?

    Yes, in that there was a significant number of patientsd presenting with resistance with only a few drugs/combinations being effective as treatments.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    More detail as to the specifics of the methods used would be advised. Not familiar with these meothods and was not provided with alot of information in article as to the methology used.


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    See notes above.


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    More graphs/data showing the drug/bacteria interactions would be great.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    This is a solid paper


  • Other Comments:

    No

  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I am a graduate student and have extensive lab experience.

  • How to cite:  Germany K .Antibiotic Sensitivity and Phenotypic Detection of ESBL producing E.Coli Strains Causing Urinary Tract Infection In A Community Hospita;l, Channai, Tamil Nadu, India.[Review of the article 'Antibiotic Sensitivity and Phenotypic Detection Of ESBL producing E.Coli Strains Causing Urinary Tract Infection In a Community Hospital, Chennai, Tamil Nadu, India. ' by Prabavathy J].WebmedCentral 2013;5(12):WMCRW003149
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  • What are the main claims of the paper and how important are they?

    The main claims of this paper are that Urinary tract infections are very common and occur in and out of a hospital setting. As antibiotics advance bacterial resistance to these drugs advance as well. Therefore it is important to understand and determine the prevalence and susceptibility of ESBL in urine samples of patients at a popular hospital in their community. More specifically it claims that ESBL producers are resistant to third generation antibiotics and this could be caused by overuse of common antibiotics prescribed for such conditions.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Although it has been reported that the overuse of antibiotics can lead to drug resistance the majority of the claims they make are novel.


  • Are the claims properly placed in the context of the previous literature?

    Yes claims were properly placed and previous literature was used adequately.


  • Do the results support the claims? If not, what other evidence is required?

    Yes the results do in fact support the claim but I think it would have been even more convincing if they used more test subjects.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No deviations from the protocol were reported.


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes, valid procedures and methodology were followed and these experiments could easily be reproduced


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    I believe the sample size could have been larger. This would have allowed them to compare types of UTI infections that occur in different hospitals to see if the pattern is consistent. 


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    I think this paper was rather ordinary. No outstanding claims were made that make it stand out over and above any other study in its discipline. Although I do think that this information should be shared with health care workers in this field so that they can be more aware and prescribe antibiotics only when absolutely needed so that patients do not develop resistance. 


  • Other Comments:

    Overall this article was very well written, informative and easy to grasp.

  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I am currently a Ph.D. student at the University of Kentucky in Pharmaceutical Sciences (Drug Discovery).

  • How to cite:  Hayden R C.Antibiotic Sensitivity and Phenotypic Detection Of ESBL producing E.Coli Strains Causing Urinary Tract Infection In a Community Hospital[Review of the article 'Antibiotic Sensitivity and Phenotypic Detection Of ESBL producing E.Coli Strains Causing Urinary Tract Infection In a Community Hospital, Chennai, Tamil Nadu, India. ' by Prabavathy J].WebmedCentral 2013;5(11):WMCRW003143
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  • What are the main claims of the paper and how important are they?

    Commonly used antibitics to treat UTI had been screened with a fair number of samples from suspected patients to see the efficacy of them. In a world of ever increasing use of antibiotics to treat patients it is very important to test and find out the result of the usage and to recommend the suitability of drugs in case of development of resistance is a constant endevour of medical researchers. in this aspect the study is quite relevant.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    The methodology used for for this study is quite adequate and a fair number of samples have been tested in the specified period of time frame


  • Are the claims properly placed in the context of the previous literature?

    Adequate  survey of literature had been carried out upto 2011 which itself suggests the sequence of the study

    in its right time frame

     

     


  • Do the results support the claims? If not, what other evidence is required?

    The of the result systamatic order of testing  the samples for the presence of UTI which is followed by the administration of antibiotics and the suitability of the concerned drug were well documented using standard procedures


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    Since the procedured were conducted through standardised laboratory procedured I have nothing to comment about it


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Valid procedures and lab practices have been followed


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    A molecular level study could be carried out if resources permit.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Apaper will not be complete unless it presented to bigger audience for construcive criticism and contribution and any worth while findings should be known to public especially in a field like 'the random and indiscrminate use of antibiotics


  • Other Comments:

    By and large the paper brings out the result of a systamtic evaluation antibitic usage among human subjects

  • Competing interests:
    Reproductive technology, Embryo preservation and Transfer
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    More than 15 years

  • How to cite:  Anonymous.Antibiotic sensitivity and phenotypic detection of ESBL producing E.coli strains causing urinary track infection (UTI) in a community hospital at Chennai, Tamil nadu, India[Review of the article 'Antibiotic Sensitivity and Phenotypic Detection Of ESBL producing E.Coli Strains Causing Urinary Tract Infection In a Community Hospital, Chennai, Tamil Nadu, India. ' by Prabavathy J].WebmedCentral 2013;4(1):WMCRW002429
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  • What are the main claims of the paper and how important are they?

    The main claims of the paper  is to find out the prevalence of ESBL producers in urinary isolates of E.coli and also their susceptibility to commonly used antibiotics including the sex and the age group of people who are more susceptible for infection.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes,the research work is aimed to findout the suitable antibiotic to cure the UTI in the patient as the resistant type of bacteria are developed


  • Are the claims properly placed in the context of the previous literature?

    Yes, the results are discussed with the earlier research papers and the conculusion is inferred.


  • Do the results support the claims? If not, what other evidence is required?

    Yes, the experiments are designed insuch a way the results are supporting the claims


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    The flowchart is given and there is no deviation


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes, the experiments are designed  following the international  research papers and the results are reproducible


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    It is sufficient


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    it is inferred that all the isolated ESBL producers were resistant to third generation cephalosporins like ceftazidime, cefapodoxime, cefatoxime and cefuroxime but are still sensitive to carbapenems like Imipenem and Ertapenem and also highly responds to combination of drugs like Piperacillin/Tazobactum and Cefperazone/sulbactum.Therefore,this paper suggerst a suitable medicine to cure the UTI in the patient


  • Other Comments:

    The findings of the present study showed an increase in the prevalence of resistance to a number of commonly used antibiotics to an alarming level. Many isolates were found to be resistant to atleast 3 - 5 antibiotics. In view of this emerging drug resistance the practice of routine ESBL testing for uropathogens along with conventional antibiogram would be useful for all cases which will help in the proper treatment of the patient and also prevent further development of bacterial drug resistance. Drug resistance surveillance in hospital is necessary to know the impact of higher drug resistance of the urinary isolates prevailing in their population which will lead to the formation of a strict antibiotic policy thereby reducing the resistance level.

  • Competing interests:
    Yes, I am a Scholarly Reviewer & Faculty of WebmedCentral
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:

    2. Dhanya Nishant, S Rajan, Sadananda Rai, S. Gokul Shankar, K. Babu and S. Subashini, 2009. Studies on the antimicrobial activity of plunbago indica L. on certain Human skin microflora, Bull Biol. Sci. Vol. VII (2nd issue) – 129 – 134.

  • Experience and credentials in the specific area of science:
    None
  • How to cite:  Rajan S .Antibiotic Sensitivity and Phenotypic Detection Of ESBL Producing E.Coli Strains Causing Urinary Tract Infection In a Community Hospital[Review of the article 'Antibiotic Sensitivity and Phenotypic Detection Of ESBL producing E.Coli Strains Causing Urinary Tract Infection In a Community Hospital, Chennai, Tamil Nadu, India. ' by Prabavathy J].WebmedCentral 2013;3(11):WMCRW002350
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