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An Efficient Pharmacophore Generation Strategy To Identify New Leukotriene A4 Hydrolase (lta4h)
By Mr. Kranthi Raj K , Dr. Ramachandran D , Ms. Rekha R , Dr. Muttineni Ravikumar , Dr. P. Jhansi Lakshmi
Submited on: 23 Aug 2010 05:36:05 AM GMT
Published on: 23 Aug 2010 08:40:25 PM GMT
 
An Efficient Pharmacophore Generation Strategy to identify new leukotriene A4 Hydrolase(lta4h)
Posted by Dr. Nagendra Amrthala on 16 Nov 2010 11:39:30 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
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  • Computational Drug Discovery is a new tool used by scientists these days, I think this strategy is very good and can be helpful in identifying new inhibitors or drugs.

  • Invited by the author to review this article? : No
  • Experience and credentials in the specific area of science:

    I am mostly in the organic synthesis part

  • Publications in the same or a related area of science: No
  • References: None
  • How to cite:  Amrthala N .An Efficient Pharmacophore Generation Strategy to identify new leukotriene A4 Hydrolase(lta4h)[Review of the article 'An Efficient Pharmacophore Generation Strategy To Identify New Leukotriene A4 Hydrolase (lta4h) ' by Lakshmi P].WebmedCentral 2010;1(11):WMCRW00142
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It is very interesting research article
Posted by Dr. Seshu Kumar V on 07 Oct 2010 06:52:36 AM GMT

  • I have gone through some related articles before, but the way of presenting the work is good.
  • Invited by the author to review this article? : Yes
  • Experience and credentials in the specific area of science: Just heard and gone through some articles
  • Publications in the same or a related area of science: No
  • References: None
  • How to cite:  Kumar V S .It is very interesting research article[Review of the article 'An Efficient Pharmacophore Generation Strategy To Identify New Leukotriene A4 Hydrolase (lta4h) ' by Lakshmi P].WebmedCentral 2010;1(10):WMCRW0055
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Congratulations to this great technique
Posted by Prof. Heidrun Karlic on 03 Sep 2010 06:16:40 PM GMT

  • This is to document my opinion indicating that this is indeed a very interesting article! I never heard before about this fascinating pharmacophore generation strategy!
  • Competing interests: No
  • Invited by the author to review this article? : No
  • Experience and credentials in the specific area of science: Some years ago, I did some research on a key enzyme of Leukotriene-Synthesis (5-Lipoxygenase) Pfeilstocker M, Karlic H, Guthann E, Lohninger A, Nosslinger T, Pittermann E. Association of Carnitine Acyltransferases, Ga16 and 5-Lipoxygenase with Apoptosis in MDS. Blood 112, 915a (abstract No. 3404*) 45th Meeting of the American Society of Hematology, Dec. 6-9 2003, San Diego CA
  • Publications in the same or a related area of science: No
  • References: None
  • How to cite:  Karlic H .Congratulations to this great technique[Review of the article 'An Efficient Pharmacophore Generation Strategy To Identify New Leukotriene A4 Hydrolase (lta4h) ' by Lakshmi P].WebmedCentral 2010;1(9):WMCRW0027
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Thankyou for review prof. Heidrun Karlic.
Responded by Mr. Kranthi Raj K on 06 Sep 2010 06:01:41 AM