Submited on: 18 Dec 2011 09:21:17 AM GMT
Published on: 19 Dec 2011 03:45:21 PM GMT
 
Antifungal Use for Opportunistic Infection in HIV Patients
Posted by Dr. William J Maloney on 14 Feb 2014 01:29:52 PM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    The authors' aim is to compare the efficacy and safety of antifungal use for opportunistic infection in HIV patients.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    Yes


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    No


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes- this would be a great seminar for anyone involved in direct patient care.


  • Other Comments:

    The most common fungal infections in individuals with HIV are candidiasis, cryptococcal meningitis and histoplasmosis.  The authors state that therapeutic regimens which are recommended induce various types of adverse reactions or side effects.  They suggest routine drug adjustment and therapeutic drug monitoring.  This article is extremely well referenced.

  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    Clinical associate professor

  • How to cite:  Maloney W J.Antifungal Use for Opportunistic Infection in HIV Patients[Review of the article 'Antifungal Use for Opportunistic Infection in HIV Patients: Comparison of Efficacy and Safety ' by Harun S].WebmedCentral 2014;5(2):WMCRW002981
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