Open Access Biomedical Publisher Using Post Publication Peer Review
On my opinion the main claim of the paper and the main theory of the author is: UTS may be locomotor evolution in reverse
The syndrome is named according to author name. The claims are novel.
The results support the claims.
it is not any randomised control trial prescribed at the methods of the study. The syndorme is rare and the patients are part of some well defined families included in the study.
The paper is continuing some other studies/papers authored by Professor Tan previously.
Yes it is outstanding and it will be a pleasure to include it at our presentations. The main value is its originality.
(i) Do the UTS cases use LS and/or DS walking gait?;
(ii) How might the locomotion of UTS cases be related to that of nonhuman primates?
(iii) Are the UTS cases examples of a locomotor evolution in reverse
The main claims of the paper are:
1. UTS cases walk with straight rather than flexed legs
2. QL in UTS is mostly lateral sequence,
3. There are similarities in gait characteristics with terrestrial primate locomotion
4. QL in healthy individuals had similarities with arboreal primate locomotion.
5. UTS may be locomotor evolution in reverse
Yes, all claims are novel
Yes, except the last claim (reverse evolution)
No protocol. Only 32 members from 10 families were studied
MRI of head of UTS, normal humans, terrestrial primates and arboreal primates would have added to the quality of paper.
Comparison of the Cerebellum and Basal Ganglia of each of these would have thrown more light.
It is known that several cases of UTS have inferior Cerebello-vermian hypoplasia. It is quite possible that this was responsible for the posture and gait of UTS, rather than any 'reverse evolution'
Quite outstanding paper, from an evolutionary biologist's point of view but less so from a Neuroscientist's point of view
Uner Tan himself being a evolutionary biologist, he focussed more on comparative analysis of primates and humans and UTS cases.
From a Neuroscience perspective a comparison of the brain scans of these subjects would have been more informative.
I have published nearly 100 dissection videos of Cerebellum, Cerebrum, Basal Ganglia on Web-based media (YouTube, Slideshare Behance, MERLOT)
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