Submited on: 02 Sep 2013 08:55:13 AM GMT
Published on: 02 Sep 2013 10:35:25 AM GMT
 
Review The mutagenesis-selection-cascade theory of sexual reproduction
Posted by Dr. Dipak Kumar Sahoo on 19 Jun 2016 10:26:30 AM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    The mutagenesis-selection-cascade theory of sexual reproduction


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    Yes


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    NA


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Not required.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    This paper is outstanding.


  • Other Comments:

    NA

  • Competing interests:
    .
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I have been working in the field of reproduction and oxidative stress since last 12 years.

  • How to cite:  Sahoo D .Review The mutagenesis-selection-cascade theory of sexual reproduction [Review of the article 'The mutagenesis-selection-cascade theory of sexual reproduction ' by Heininger K].WebmedCentral 2016;7(6):WMCRW003290
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Revie on The mutagenesis-selection-cascade theory of sexual reproduction
Posted by Prof. Kulvinder K Kaur on 26 Sep 2013 04:39:32 AM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    The author has written an extensive review comprising of 581 pages with 8500 references trying to give the rationality of sexual reproduction(SR) in evolution.SR present in eukaryotes carries 2fold cost as compared to asexual reproduction and has used joint holistic and reductionist approaches to solve what bell calls the queen of all problemsin evolution.In everchanging environments quality of offspring more important than quality -hence theoretically2fold cost becom,es mmeaningless-in environmental challenges organisams take up free DNA to use it as template for DNA repair ,increase genetic response-thus organisms poorly adapted to environment betghedge (stress response)-boost fitness,-what evolved as reactive processto env challenge -genetic accomodatedin higher taxa as cybernetic engine,multiple evidence-metabolic/oxidative stress-generate genetic variationof gametes in higher taxa(eg mammalian testis descent),stochasticmutagenesis/epimita--high risk deleterious-evolutionaryfateof mutatirs linked to population size (PS)-only withlarge PS change any beneficial mutations-under env stress microrg take adv of large PS create increase no.of mutations-let mitator select mutants best fit 4 actual environment-evolution took advantage in SR by using alternative approach to invest into small mutated units and bethedge with larger no of gametes populations -huge energetic investment into waste production leads to great oxidative and gonadal hypoxic stress besides huge waste of male gametes2000sperm/sec shd defer from investment -SR.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes- Nobody has so comprehensively summed up this detailed evolutionary process with all molecular details considering all asexual and sexual taxa but the papers available in field are 1)Badyadaev AV Homeostatic hitchhiking :amechanism for the evolutionary retention of complex adaptations Integ Comp Biol2013 july 18Epub ahead of print 2)Jablonka E Epigenetic variation in heredity and evolution Clin Pharmacol Ther 2012;92(6):683-8.3)Becks L,Agrawal AF The evolution of sex is favoured during adaptation in new environmentsPLoS BIOLOGY 2012;10(5):e1001317;1-11 4)Badyadev AV Origin of the fittest:link between emergent variation and evolutionary change as a critical question in evolutionary biology.Peoc R Soc B 2011;278:1921-1929. 5)Badyaev AV Evolutionary significance of phenotypic accommodation in novel environments :an emprrical test of the Baldwin effect.Phil Trans R Soc 2009;364:1125-1141.Feng G,Leem YE,Levin HL-Transposon integration enhances expression of stress response genes.Nucleic Acids Research 2013;41(2):775-789.


  • Are the claims properly placed in the context of the previous literature?

    Yes except references are not there whichj are mentioned in text and the figures mentioned are not provided.


  • Do the results support the claims? If not, what other evidence is required?

    Yes- But for the reader the references mentioned need to be provided to countercheck the reference as same are not found in the reference list-so much si thst the authors own article of 2012 cited so many times and published in webmed cedntral is not mentioned in references.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    NA


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    NA


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    One is providing references and secondly to cut short the paper to keep the interest of reader it is better if references are cited as numbers rather than whole list in text which increases the bulk of text although the author hsas beautifully summarized before every section i think only readers who are capable of understanding this articl;e will read so i think to avoid volume and bulk of articfloe thefe is no need of summary just before start of every section although i feelnobody to be criticizing such a wonderful work but it becomes very boring going through over 235 pages and so many references and please provide the figures as you possibly forgot to add them in the end although mentioned in the text.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes but provided references are properly cited and figures provided and more comprehensive made


  • Other Comments:

    The author accidentally discovered this while doing his extensive research on ageing and this exemplifies how humanbody is not splitinto different compartments which we try to label neurologist,cardiologist,endocrinologist,physician,obstetrician as if humanbody can be segregated into parts and how much interelated systems are and roles of trnsposon elements in DNA replication,role of cambrian explosion and firther advantages of asexual intermictics and why only in 6-7 billion years sexual reproduction and eukaryotes probably came akthough for one DNA change to occur it takes over 1 billion yars and tole of oxygen arrivuing and how oxidative sgtress and asvaNTAGES OF MULLERS RACHERLAMARCKIAN,DARWINIAN all theories well tackled and role of tumor suppressor gene p53 in various functions well exemplified and how it controls nmmitovhondrial DNA and role of DNA homoplasmy-why essential and disadvantage of heteroplasmy and mt DNA diseases all comprehensively discussed.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:

    Presented paper in 7th IBRO world congress of.NEUROLOGY held in melboutne australia from 12-17th july 2007 entitled role of dysregulation of ANSvs HPA uin drug induced obesity and confused hypothalamus as a cause of worldwide obesity in 13rh world congress of gynaecological endocrinology held in florence italy i 2004,besides have been practicing gynaecological neuroendocrinology for over 30 years and doing research in obesity ,neuroendocrine control of GnRH secretioncontrol etc.

  • Experience and credentials in the specific area of science:
    None
  • How to cite:  Kaur K K.Revie on The mutagenesis-selection-cascade theory of sexual reproduction [Review of the article 'The mutagenesis-selection-cascade theory of sexual reproduction ' by Heininger K].WebmedCentral 2016;4(9):WMCRW002868
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