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Other Comments:
Why studies were conducted at 50 0 C.
Expalin and discuss about the mechanism of drug release from microspheres.
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Competing interests:
No
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Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
I have published an article Microsphere formulation of acceclofenac in Acta Pharm.
- How to cite: Patro C .Investigation of drug polymer compatibility: Formulation and characterization of Metronidazole microspheres for colonic delivery[Review of the article 'Investigation of Drug Polymer Compatibility: Formulation and Characterization of Metronidazole Microspheres for Colonic Delivery. ' by Behera S].WebmedCentral 2016;3(5):WMCRW001823
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Other Comments:
The area of topics is good and the work have done is also good bt in case of incopatibility study if DSC data included then it will be strong work. But still it is a good work and many researcher are get helped from this article.
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Competing interests:
mucoadhesive, in situ gel, enteric coating, microspheres, microcapsules, floating, transdermal patch.
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Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
Yes
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References:
None -
Experience and credentials in the specific area of science:
I worked in this topics and i have 2 publication of this area.
- How to cite: Goswami D s.Investigation of Drug Polymer Compatibility: Formulation and Characterization of Metronidazole Microspheres for Colonic Delivery.[Review of the article 'Investigation of Drug Polymer Compatibility: Formulation and Characterization of Metronidazole Microspheres for Colonic Delivery. ' by Behera S].WebmedCentral 2016;3(5):WMCRW001817
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Other Comments:
The article may be published in the present form.
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Competing interests:
No
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Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
7 years of research
- How to cite: Bhowmik M .Investigation of Drug Polymer Compatibility: Formulation and Characterization of Metronidazole Microspheres for Colonic Delivery. [Review of the article 'Investigation of Drug Polymer Compatibility: Formulation and Characterization of Metronidazole Microspheres for Colonic Delivery. ' by Behera S].WebmedCentral 2016;3(5):WMCRW001792
Responded by Mr. Prasanta K Choudhury on 10 May 2012 05:50:38 PM
Previous Version:
Investigation of Drug Polymer Compatibility: Formulation and Characterization of Metronidazole Microspheres for Colonic Delivery.
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Other Comments:
The paper submitted by Choudhury and colleagues addresses and interesting and important topic in the field of targeted drug delivery. Metronidazole has been used as an essential drug and targeted delivery to the colon remains a core issue. The current study addresses the formulation, stability, and release profile for various ethyl cellulose formulated microspheres. The authors build upon a small body of knowledge that establishes ethyl cellulose as a delivery vehicle for colon-targeted drugs. Overall the paper is well written - some methods (e.g. particle size determination) have not been well defined and should be revised or added. The diction requires some improvements - certain sentences are not comprehensible although the message that the authors wish to convey gets across.
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Competing interests:
I have no competing interests.
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
Pharmacists, teaching pharmacy students
- How to cite: Grundmann O .Assessment of submitted article[Review of the article 'Investigation of Drug Polymer Compatibility: Formulation and Characterization of Metronidazole Microspheres for Colonic Delivery. ' by Behera S].WebmedCentral 2016;3(5):WMCRW001760
Responded by Mr. Prasanta K Choudhury on 02 May 2012 02:44:29 AM
The authors primarily claim that metronidazole (MNZ) is compatible with ethyl cellulose microspheres. If true, this claim would be relatively high-impact, given the utility of extended delivery formulations of MNZ for delivery to the colon. However, the study is limited to a specific formulation of MNZ only, which cannot be directly translated to other formulations.
To the reviewer’s best knowledge, no other works have been published which characterize the compatibility of MNZ in ethyl cellulose microspheres. However, one paper (Bhowmik B.B., Nayak B.S., Chatterjee A.: Int. J. Pharm. Pharm. Sci. 1, 240 (2009).) describes the physical and chemical characteristics of MNZ mixed with hydrogels of several polymers, including ethyl cellulose. However, this is only marginally relevant. Thus, this paper describes relatively novel research, albeit somewhat limited in scope.
The author provides a concise yet thorough review of the importance of understanding drug-excipient interactions, along with relevant experimental technology and the clinical utility of MNZ microspheres for colon delivery. However, this discussion is linked to previously published works to a minimal degree; the only referenced works are one describing the theory of IR spectroscopy and a therapeutic analysis of MNZ. More extensive context with other research might be beneficial.
The results do sufficiently prove that MNZ-ethyl cellulose microspheres are compatible in 10% ethanol-water solutions at a temperature of 50 degrees Celsius for at least two weeks. However, only this solution condition is evaluated, while a true clinical formulation would be exposed to significantly different environments in vivo. Experiments in these solutions, such as highly acidic or basic aqueous solutions that the microspheres would need to pass through to reach the colon, would provide much greater confidence in the stated claim.
No protocol deviations are reported.
It is this reviewer’s opinion that the experimental methods are sufficiently discussed to allow for independent researchers to attempt to reproduce the reported results.
As previously stated, conduction of the same experiments in different solutions that are physiologically relevant would significantly improve the paper. It seems that this would be equally difficult to conduct and report as the currently reported experiment, as they would be nearly identical.
While the research is effectively presented and appears to represent appropriately conducted science, the scope is fairly limited. However, if the suggested further experiments were conducted, then this reviewer would find that the cumulative report would be highly useful in this field.
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I do have suitable experience and knowledge to review this article.