Submited on: 19 Nov 2016 09:59:41 PM GMT
Published on: 21 Nov 2016 07:10:52 AM GMT
Errors in sample handling
Posted by Mr. Jim Johnson on 05 Dec 2016 02:06:56 AM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    Errors in sample handling can produce errors in potassium, sodium and calcium ion measurements in blood.

  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    This paper demonstrates the need for careful sample handling.  There are existing FDA guidances for clinical sample handling and laboratories that make a similar point, e.g.,



  • Are the claims properly placed in the context of the previous literature?


  • Do the results support the claims? If not, what other evidence is required?

    The claims could certainly be explained by the reported results.  Additional analytical methods might be able to provide confirmation.

  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No protocol or deviations are described. However, the brief case report could itself be considered the description of a deviation from best practice.

  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    What kind of blood analyzer was used?

  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Could the original sample be checked for the presence of EDTA by a reference method like GC or LC-MS/MS?

  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?


  • Other Comments:

    Reference 1 is not available at the hyperlink (connection resets).

  • Competing interests:
  • Invited by the author to review this article? :
  • Have you previously published on this or a similar topic?:
  • References:
  • Experience and credentials in the specific area of science:


  • How to cite:  Johnson J .Errors in sample handling[Review of the article 'False laboratory results after a routine blood test: To be cautious ' by Una Cidon E].WebmedCentral 2016;7(12):WMCRW003349
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