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Other Comments:
The work is interesting and worth publishing, nevertheless, the role of P450 4A under norml conditions, is not well explained, neither its relationship to microvesicular steatosis.
Tables 1 and 2, and Figs. 1 and 2 could not be seen with the article.
Thank you,
Khalid M. Abu-Salah -
Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
None - How to cite: Abu-Salah K .Untitled[Review of the article 'Hepatic Cytochrome P450 4a Expression Level In A Rat Model Of Microvesicular Steatosis ' by Abdul Majid A].WebmedCentral 2017;1(12):WMCRW00257
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Other Comments:
the auther may need to clarify the aim of the work in the introduction part more clearly ad also to focus more on the sigifact of the findings in the result and descussion part.
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Competing interests:
no
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Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
i am teacing toxogolgy to the pharmacy students. I aslo conducted some animal toxogological studies for some anticancer agents.
- How to cite: Zihlif M .Hepatic Cytochrome P450 4a Expression Level In A Rat Model Of Microvesicular Steatosis [Review of the article 'Hepatic Cytochrome P450 4a Expression Level In A Rat Model Of Microvesicular Steatosis ' by Abdul Majid A].WebmedCentral 2017;1(12):WMCRW00218
Microvesicular steatosis induced CYP4A upregulation in liver.
The results may indicate expression of metabolic enzymes change during hepatic steatosis and this may result in an altered drug metabolism status during liver diseases.
Yes, for this subtype CYP4A of CYP450s in this hepatic steatosis model.
Not really.
Yes, but not adequate. For example, the researchers did not explain any mechanisms for this phenomenon they have observed. Which pathway is involved and which protein may account for the upregulation of CYP4A.
Not applicable for this research article.
It’s valid. Yes, there are details regarding the methods.
The model is induced by using short-term intake of diets containing Orotic acid and conducted in rats. Typically long-term high fat diet induced mouse model is more reliable and obtain a better simulation for hepatic steatosis in human.
No. There are a lot of decent articles with high quality results which published on journal of hepatology in this research area. The data from this paper is informative but very limited.
For the research background, the author introduced steatosis and lipid metabolism in liver under diet-induced model including the role of L-FAB and PPAR, however he/she failed to state the reason why they pay attention to CYP450 4A in this specific model, how CYP450 4A expression might be related with aforementioned regulators
Their technique for presenting research data is obsolete, for showing the weight mass changes in Table 1&2, graph is preferable than just listing the numbers.
The potential value of this research for finding the raising expression level of CYP4A in liver steatosis model is not well-defined, also there is no further elaboration for this phenomenon or complementary statement for demonstrating the demerits of this study.
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No
No
None
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