Submited on: 02 Oct 2010 06:59:57 AM GMT
Published on: 02 Oct 2010 07:35:34 PM GMT
 

  • What are the main claims of the paper and how important are they?

    The main claim of this article is that Lactobacillus casei can be used to protect animals from enteropathogenic Escherichia coli infection. 


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    This claim, although not surprising, is indeed novel. 


  • Are the claims properly placed in the context of the previous literature?

    Yes.


  • Do the results support the claims? If not, what other evidence is required?

    The results, although very poorly presented, do support the claim.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    Not applicable. 


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes. My only comment with regards to this is that the fact that animals received daily doses of L. casei should be more clearly indicated in the "Experimental schedule" section. This is clearly stated in the abstract, but not in the main body of the paper.


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    No.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    This paper is certainly not outstanding. It is very poorly written and the subject itself is not groundbreaking. Although the research is novel and interesting, the fact that administration of L. casei protects against an enteric pathogen is highly intuitive and expected.


  • Other Comments:

    As I mentioned above, this paper would benefit enormously from a revision of grammar, word choice, and sentence structure. The language used is so poor that sometimes it is difficult to understand the scientific concepts and reasoning presented.  

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
  • Experience and credentials in the specific area of science:

    Over 15 years of experience in microbiology research.

  • How to cite:  Antunes L M.Antiinflammatory, Antimicrobial and Immunomodulatory Properties of Lactobacillus Case Against Enteropathogenic Escherichia Coli[Review of the article 'Antiinflammatory, antimicrobial and immunomodulatory properties of Lactobacillus casei against Enteropathogenic Escherichia coli ' by Kumar A].WebmedCentral 2010;3(7):WMCRW002097
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  • Other Comments:

    Nice worth reading article

  • Competing interests:
    no
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    Experience in immunology

  • How to cite:  Parkash O .Antiinflammatory, Antimicrobial And Immunomodulatory Properties Of Lactobacillus Casei Against Enteropathogenic Escherichia Coli [Review of the article 'Antiinflammatory, antimicrobial and immunomodulatory properties of Lactobacillus casei against Enteropathogenic Escherichia coli ' by Kumar A].WebmedCentral 2010;1(11):WMCRW00132
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  • Other Comments: The work is seems to be nice and informative. Because,this article indicated many benefits of oral administration of L. casei against pathogenic E. coli. It has mentioned that the wistar rats administered with L. casei shown increased hemoglobin, better liver functions, anti-inflammatory and Immunomodulatory property against enteropathogenic E. coli. Conclude, gastrointestinal tract immunity against enteropathogenic E. coli may be generated by using L. casei (either live or dead) as a food or vaccine through oral route.
  • Competing interests:
    No
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:
    Previous experience in Microbiology, Immunology, Biochemistry (areas of Life science). Presently I am working against viral diseases which are mainly affecting in Central Part of India.
  • How to cite:  Deval H .Oral administration of L. casei as an immunomodulator against pathogenic E. coli[Review of the article 'Antiinflammatory, antimicrobial and immunomodulatory properties of Lactobacillus casei against Enteropathogenic Escherichia coli ' by Kumar A].WebmedCentral 2010;1(11):WMCRW00115
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ORAL VACCINE AGINST INFECTIOUS TRAUMAS
Posted by Dr. Vinod N Singh on 03 Oct 2010 05:20:10 AM GMT

  • Other Comments: NICE WORK SHOWING PROPERTIES OF PROBIOTICS
  • Competing interests:
    NO
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    None
  • Experience and credentials in the specific area of science:
    ALREADY WORKING ON THE IMMUNOMODULATION OF PROBIOTICS
  • How to cite:  Singh V N.ORAL VACCINE AGINST INFECTIOUS TRAUMAS[Review of the article 'Antiinflammatory, antimicrobial and immunomodulatory properties of Lactobacillus casei against Enteropathogenic Escherichia coli ' by Kumar A].WebmedCentral 2010;1(10):WMCRW0050
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