Submited on: 10 Mar 2011 08:25:13 AM GMT
Published on: 10 Mar 2011 09:54:32 PM GMT
 
Hereditary Ectodermal Dysplasia
Posted by Dr. William J Maloney on 27 Sep 2012 08:36:10 PM GMT

  • What are the main claims of the paper and how important are they?

    The main purpose of this article is to describe a case of hereditary ectodermal dysplasia.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    Yes


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    Yes


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    No


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes, It would be a great presentation at either a dental or medical school.


  • Other Comments:

    Ectodermal dysplasias are a group of disorders which are characterized by developmental dystrophies.  It is an x-linked recessive disorder.  The etiology of ectodermal dysplasia is genetic.  The skin, teeth, hair, nails, and exocrine glands are affected.

    The authors conclude that a careful and thorough examination will lead to an accurate diagnosis and that the restoration of normal function should be the main concern in these patients.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:

    No

  • Experience and credentials in the specific area of science:

    Clinical associate professor

  • How to cite:  Maloney W J.Hereditary Ectodermal Dysplasia[Review of the article 'Hereditary Ectodermal Dysplasia - A Case Report ' by Rao K].WebmedCentral 2011;3(9):WMCRW002258
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Hereditary Ectodermal Dysplasis - Case Report
Posted by Dr. Nandita Shenoy on 25 Nov 2011 05:39:37 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? No
5 Are structure and length satisfactory? No
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? Yes
8 Is the quality of the diction satisfactory? No
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? No
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:
    • Ectodermal dysplasia is not an  extremely rare genetic disorder as stated in the manuscript
    • "Ectodermal dysplasia is an X linked recessive disorder" which is not true. Ectodermal dysplasias are can be autosomal dominant, autosomal recessive and X- liked disorders.
    • This condition can affect males and females equally.
    • Method of estimation of salivary flow not mentioned
    • Please check English grammar and style
    • Discussion should have been a little longer.
    • Genetic levels and grades are not discussed in detail.
    • Rehabilitation and prosthetic management could have been discussed
    • Overall not very well documented and not a rare condition to report. 
  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    This is the specialty i deal with every day..

  • How to cite:  Shenoy N .Hereditary Ectodermal Dysplasis - Case Report[Review of the article 'Hereditary Ectodermal Dysplasia - A Case Report ' by Rao K].WebmedCentral 2011;2(11):WMCRW001157
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? No
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    well presented the diagnosis part but management of such case need to be presented in detail like 

    is it tooth supported fixed prosthesis or implant supported prosthesis?

    what about the follow-up problems?

    what were the post-operative instructions given to the patient?

  • Competing interests:
    no
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    follow-up of three years of such hereditory ectodermal dysplasia cases.

  • How to cite:  Singh B P.Hereditary Ectodermal Dysplasia - A Case Report [Review of the article 'Hereditary Ectodermal Dysplasia - A Case Report ' by Rao K].WebmedCentral 2011;2(10):WMCRW001017
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? No
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? No
5 Are structure and length satisfactory? No
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? No
9 Are the illustrations and tables necessary and acceptable? No
10 Are the references adequate and are they all necessary? No
11 Are the keywords and abstract or summary informative? No
  • Other Comments:

    abstract is too general

     

    update references

     

    check english grammar and style

     

    expand discussion

     

    add some other images

     

    no significant contribution to this specific research field is provided

     

    there is confusion concerning the classification of Ectodermal dysplasias: please specify that the present patient was afflicted with Hypohidrotic form 

     

    no multidisciplinary treatment was done: no aestethic concerns, speech problems, detailed facial features,.. were analysed

  • Competing interests:
    no
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    1. Sforza C, Dellavia C, Vizzotto L, Ferrario VF. Variations in the facial soft-tissues of Italian individuals with ectodermal dysplasia. Cleft Palate-Craniofac J. 2004;41:262-267. 2. Sforza C, Dellavia C, Goffredi M, Ferrario VF. Soft tissue facial angles in individuals with ectodermal dysplasia: a three-dimensional noninvasive study. Cleft Palate Craniofac J. 2006;43:339-349. 3. Dellavia C, Sforza C, Malerba A, Strohmenger L, Ferrario VF. Palatal size and shape in 6-year-old patients affected by Hipohidrotic Ectodermal Dysplasia. Angle Orthod. 2006;76:978-983. 4. Dellavia C, Catti F, Sforza C, Grandi G, Ferrario VF. Non-invasive longitudinal assessment of facial growth in children and adolescents with Hypohidrotic Ectodermal Dysplasia. Eur J Oral Sci. 2008;116:305-311. 5. Ferrario VF, Dellavia C, Serrao G, Sforza C. Soft tissue facial areas and volumes in individuals with ectodermal dysplasia: a three-dimensional non invasive assessment. Am J Med Genet. 2004;126A:253-260. 6. Dellavia C, Catti F, Sforza C, Tommasi DG, Ferrario VF. Craniofacial growth in ectodermal dysplasia. An 8 year longitudinal evaluation of Italian subjects. Angle Orthod 80(4):545-51, 2010.
  • Experience and credentials in the specific area of science:

     

    anthropometric analysis of facial features in subjects with ectodermal dysplasia: cross-sectional and longitudinal studies

     

  • How to cite:  dellavia c p.hereditary ectodermal dysplasia- a case report[Review of the article 'Hereditary Ectodermal Dysplasia - A Case Report ' by Rao K].WebmedCentral 2011;2(4):WMCRW00667
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Ectodermal dysplasia
Posted by Dr. Mahfujul H Khan on 09 Apr 2011 05:21:46 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Partly
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    It may be accepted for publication

  • Competing interests:
    no
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    . Khan MH, Mishu MP, Sejuty H, Mohsin F: Oral Rehabilitation in Ectodermal Dysplasia. Mymensingh Med J. 2010 Oct;19(4):627-31
  • Experience and credentials in the specific area of science:

    20 years

  • How to cite:  Khan M H.Ectodermal dysplasia[Review of the article 'Hereditary Ectodermal Dysplasia - A Case Report ' by Rao K].WebmedCentral 2011;2(4):WMCRW00650
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good article
Posted by Dr. Anusha R L on 03 Apr 2011 03:51:45 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? No
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    The article is substantially good

  • Competing interests:
    No
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    1 year

  • How to cite:  R L A .good article[Review of the article 'Hereditary Ectodermal Dysplasia - A Case Report ' by Rao K].WebmedCentral 2011;2(4):WMCRW00638
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Hereditary Ectodermal Dysplasia - A Case Report
Posted by Dr. Prasanna K Rao on 28 Mar 2011 12:07:31 PM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? No
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Overall the article is fairly good.

  • Competing interests:
    Nil
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    KARNATAKA state DENTAL journal 2005 May issue.
  • Experience and credentials in the specific area of science:

    6 years of teaching experiance in Oral Medicine and Radiology.

  • How to cite:  Rao P K.Hereditary Ectodermal Dysplasia - A Case Report[Review of the article 'Hereditary Ectodermal Dysplasia - A Case Report ' by Rao K].WebmedCentral 2011;2(3):WMCRW00632
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? No
3 Is this a new and original contribution? No
4 Does this paper exemplify an awareness of other research on the topic? No
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? Yes
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? No
11 Are the keywords and abstract or summary informative? No
  • Other Comments:

    Dear Webmed Central team, thank you for your invitation to review the article entitled " Hereditary Ectodermal Dysplasia - A Case Report " by Babu S et al. My comments are as follows:

     

    • Regarding abstract, authors mentioned that" Ectodermal dysplasia is an extremely rare genetic disorder" which is not true. It is a rare disorder or a common genetic disorder. Authors also mentioned that "It usually affects the males and females are the carriers". This is true only in the X- linked type while the other 2 types (autosomal dominant and autosomal recessive) affect both males and females equally.

     

    • Regarding introduction, authors mentioned that "Ectodermal dysplasia is an X linked recessive disorder" which is not true. Ectodermal dysplasias are characterized by genetic heterogeneity i.e. transmitted as autosomal dominant, autosomal recessive and X- liked disorders.

     

    • OMIM (On line Mendelian Inheritance in Man) number should be mentioned.

     

    • Regarding case report, I estimated that the present case is an X linked type. The pedigree (family tree) should be taken. Mother is a carrier of the affected gene and should be examined because partial manifestations as missing upper lateral incisors could be reported.

     

    • Regarding discussion, authors ignored to discuss the suggested treatment regarding periodontal condition and previously published treatment modalities.

     

    • Finally I have a negative decision. The article reported a well-known and well-documented condition and did not describe the management in detail without a long-term follow-up.

     

     

    Thank you.

  • Competing interests:
    Not
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    ElShenawy H, Elkhodary A, Saafan A, Sharaf H, Al-Hadedi S, Mostafa M. Management Of Periodontitis In Patients With Down Syndrome Using Low Energy Diode Laser. WebmedCentral DENTISTRY 2010;1 (10):WMC00990. El Darouti M, Zayed A, El Kamah Gh, Mostafa M. Ligneous conjunctivitis with severe ligneous periodontitis and decreased serum plasminogen: the first Egyptian case report. Pediatric Dermatology; Vol. 26 No. 4 448?451, 2009 El Kamah Gh, Mostafa M. Heterogeneity & Atypical Presentation in Infantile Systemic Hyalinosis with Severe Labio-Gingival Enlargement: First Egyptian Report. Dermatology online journal;15(5) ; 2009. Temtamy S A, Aglan M S, Ashour A M, Ramzy M.I., Hosny L A and Mostafa M I: 3-M syndrome: a report of three Egyptian cases with review of the literature. Clinical Dysmorphology;15(2):55-64, 2006 Mostafa M I, Temtamy S A, El Gammal M A and Mazen I M : Unusual pattern of inheritance and orodental changes in the Ellis-Van Creveld syndrome. Genetic Counseling ; Vol. (16), No 1, 75 - 83, 2005. Kader A.M, Samy M. El Sayed M.S, El Zawahry M.M, El Ragi A.F., Mostafa I.M. Finite element analysis of denture base in Ectodermal dysplasia. Egyption Medical Journal of the National Resarch Center Vol.(9), No 2, 10 - 15, 2010. El-Kamah GhY , El-Darouti MA, Kotoury AIS, Mostafa IM. Farber disease overlapping with stiff skin syndrome: Expanding the spectrum. Egypt. J. Med. Hum. Genet. 2009; 10 (1): 97-104. Ramzy M.I., Gomaa H. E, Mostafa M.I. and Zaki B.M. : Management of aggressive periodontitis using Ozonized water. Egyption Medical Journal of the National Resarch Center, Vol.(6), No 1, 229 - 245, 2005. Afifi H H., Mostafa M.I. and Zaki M.S.: Cranioectodermal dysplasia : Two new Egyptian cases with expansion of the phenotype. Journal of Arab Child, Vol. 14, No. 2 April:145 - 158 ,2003. Ramzy M.I. , Meguid N.A., Mostafa M.I. and Hammad S.A: Oro-dental abnormalities in patients with mental retardation The Medical Journal of Cairo university, 71 (2) :263 - 271 , 2003. Temtamy S A., Abdel Salam Z A., Aboul-Ezz E H.A., Soliman S A. and Mostafa M I.: Comparison of oral,craniofacial and radiographic features in Noonan and Turner syndromes. Cairo Dental Journal, 12 (1): 13 - 20, 1996.
  • Experience and credentials in the specific area of science:

    Yes

  • How to cite:  Mostafa M I.Hereditary Ectodermal Dysplasia - A Case Report[Review of the article 'Hereditary Ectodermal Dysplasia - A Case Report ' by Rao K].WebmedCentral 2011;2(3):WMCRW00590
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