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Vascular Endothelial Growth Factor Increases Endothelial Nitric Oxide Synthase Transcription In Huvec Cells
By Dr. Esther Koai , Dr. Tibisay Rincon Rios , Dr. John Edwards
Submited on: 02 Nov 2010 10:00:55 PM GMT
Published on: 03 Nov 2010 09:28:19 PM GMT
 
Vascular Endothelial Growth Factor Increase Notric Oxide Synthetase Transcription in Huvec Cells
Posted by Dr. Sajeda M Eidan on 28 Nov 2011 06:29:09 PM GMT

1 Is the subject of the article within the scope of the subject category? Partly
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? Yes
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? No
  • Other Comments:

    I suggest to delete old references and breplaced by recent  ones published during last two years.

     

    Figures are enough as explainary tools of this article. However, tables are also necessary .

  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I found that this subject of Vacular Endothlial Grwth Factor is an important subject, related of it with cardiovacular demand. This will take consideration by cardiovacular diease patients.

  • How to cite:  Eidan S M.Vascular Endothelial Growth Factor Increase Notric Oxide Synthetase Transcription in Huvec Cells[Review of the article 'Vascular Endothelial Growth Factor Increases Endothelial Nitric Oxide Synthase Transcription In Huvec Cells ' by Edwards J].WebmedCentral 2011;2(11):WMCRW001171
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Vascular endothelial growth factor increases endothelial nitric oxide synthase transcription in HUVEC cells
Posted by Dr. Tang J on 14 May 2011 12:26:37 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    The main goal of this paper is to explore the effect of VEGF on eNOS transcription in HUVEC. In the paper, the results suggested VEGF increased eNOS transcription, which was associated with a cis-transinteraction localized to an AP1-like site within the eNOS promoter. Overall the paper is well written and most of the conclusion by the authors appears to be supported by their results. Taken in consideration the reported findings, I believe that the study might be considered for publication.

  • Competing interests:
    NO
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    1.Vascular endothelial growth factor promotes cardiac stem cell migration via the PI3K/Akt pathway. Tang J, Wang J, Kong X, Yang J, Guo L, Zheng F, Zhang L, Huang Y, Wan Y. Exp Cell Res. 2009 Dec 10;315(20):3521-31. 2.VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart. Tang JM, Wang JN, Zhang L, Zheng F, Yang JY, Kong X, Guo LY, Chen L, Huang YZ, Wan Y, Chen SY. Cardiovasc Res. 2011 Mar 18.
  • Experience and credentials in the specific area of science:

    VEGF  stem cell  cardiovascular disease

  • How to cite:  J T . Vascular endothelial growth factor increases endothelial nitric oxide synthase transcription in HUVEC cells[Review of the article 'Vascular Endothelial Growth Factor Increases Endothelial Nitric Oxide Synthase Transcription In Huvec Cells ' by Edwards J].WebmedCentral 2011;2(5):WMCRW00742
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Vascular endothelial growth factor increases endothelial nitric oxide synthase transcription in HUVEC cells
Posted by Dr. Cheol Whee Park on 13 May 2011 07:41:39 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? No
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    This interesting paper is looking at the effect of VEGF on eNOS transcription in HUVEC, and the authors clearly demonstate that VEGF increases eNOS transcription mediated by an effect through a cis-trans interaction localized to an AP-like site within the eNOS promoter.

    Study desing and methodology are adequate, the results are clear-cut, and the discussion is well-written.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    1. Long-term blockade of VEGF receptor-2 aggravated the diabetic renal dysfunction associated with inactivation of the Akt/eNOS-NO axis. Nephrol Dial Transplant 2011:26;1177-1188 2. VEGF inhibition by dRK6 causes endothelial apoptosis, fibrosis, and inflammation in the heart via the Akt/eNOS axis in db/db mice. Diabetes 2009:58;2666-2676
  • Experience and credentials in the specific area of science:

    VEGF and diabetic complications.

  • How to cite:  Park C .Vascular endothelial growth factor increases endothelial nitric oxide synthase transcription in HUVEC cells[Review of the article 'Vascular Endothelial Growth Factor Increases Endothelial Nitric Oxide Synthase Transcription In Huvec Cells ' by Edwards J].WebmedCentral 2011;2(5):WMCRW00741
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