B.S., Physics, 1972, Middle East Technical University, Ankara, Turkey
Ph.D., Biophysical Sciences, 1978, State University of New York at Buffalo (Laboratory of Prof. Shinpei Ohki)
Postdoctoral, Membrane Biophysics, 1978-1981, University of California, San Francisco (Laboratory of Prof. Demetrios Papahadjopoulos)
Awards and Fellowships
National Cancer Institute Postdoctoral Fellowship (National Research Service Award; CA-06190), 1978-1981.
Visiting Professorship, CNR Institute of Cybernetics and Biophysics, Genova, Italy, 1986.
Fellowship of the Japan Society for the Promotion of Science, Department of Biophysics, University of Kyoto, Japan, 1988.
Eberhardt Teacher-Scholar Award, University of the Pacific, 1999.
Burton C. Borgelt Faculty Advisor Award, International Association of Student Clinicians - American Dental Association, 2005.
Co-Director, Advanced Laboratory Course on "Membrane Fusion," May 8-19, 1989, University of Coimbra, Portugal.
Organizer, Workshop on "Mechanisms and Specificity of HIV Entry into Host Cells," June 19-20, 1989, San Francisco, CA.
Co-chairman, UCSF Symposium on "Liposomes: From Biophysics to Therapeutics," September 28, 1989.
Co-Director, Advanced Laboratory Course on "Membrane Fusion," May 19-30, 1991, University of Coimbra, Portugal.
Organizing Committee, U.S.-Japan Binational Seminar on "Membrane Fusion," November 8-12, 1992, Kyoto, Japan, 1992.
Organizing Committee, NATO Advance Study Institute on "Trafficking of Intracellular Membranes: From Molecular Sorting to Membrane Fusion," June 19-30, 1994, Espinho, Portugal.
Organizing Committee, International Symposium on 'Membrane Fusion: Mechanisms and Applications to Cell Biology, Drug Delivery and Gene Therapy," July 14-18, 1998, Salamanca, Spain.
Reviewer for National Science Foundation grant application (1994)
Member, NIH Review group (1997)
Chair, NIH ad hoc Study Section (2000, 2001)
Member, NIH Review group ZRG1 SSS-2, (2003)
Reviewer for Ph.D. Thesis, University of British Columbia, Vancouver, Canada (1998)
Reviewer and Committee Member for Ph.D. Thesis, University of Coimbra, Portugal (1999)
Reviewer for Ph.D. Thesis, University of British Columbia, Vancouver, Canada (2005)
Reviewer for Ph.D. Thesis, University of Kwazulu/Natal, South Africa (2005)
Reviewer for Faculty promotion, University at Buffalo, SUNY, Buffalo, NY (2006)
Reviewer for National Science Foundation grant application (2006)
Reviewer for Health Research Board of Ireland (2006)
Reviewer for Cancer Research UK (2007)
Reviewer for Ph.D. Thesis, University at Buffalo, SUNY, Buffalo, NY (2008)
Guest Editor, Proceedings of the National Academy of Sciences U.S.A. (2011)
Editorial Board, Archaea, An International Microbiological Journal (2004- )
Associate Editor, Journal of Bionanoscience (2007- )
Editorial Board, The Open Gene Therapy Journal (2009- )
Editorial Board, Recent Patents on Regenerative Medicine (2010- )
Editorial Board, Microbiology Research (2010- )
Editorial Board, Nano Reviews and Letters (2011- )
Editorial Board, World Journal of Experimental Medicine (2011- )
Membership in Professional Societies
Biophysical Society (1973-present)
American Association for the Advancement of Science (1979-present)
The American Society for Cell Biology (1982-present)
International Society for Antiviral Research (1989-present)
American Society for Microbiology (1991-present)
American Society for Virology (1994-2009)
International Association for Dental Research (1992-1995; 2002-present)
American Society of Gene and Cell Therapy (2004-present)
American Dental Education Association (2006-present)
2010-present: Professor, Department of Biomedical Sciences, University of the Pacific School of Dentistry, San Francisco.
1995-2010: Professor and Chairperson, Department of Microbiology, University of the Pacific School of Dentistry, San Francisco.
1990-1995: Associate Professor and Chairperson, Department of Microbiology, University of the Pacific School of Dentistry, San Francisco.
1987-1997: Associate Adjunct Professor, Department of Biopharmaceutical Sciences, University of California, San Francisco.
1987-1991: Member, Group in Biophysics, UCSF, San Francisco.
1988 April-May: Visiting Professor, Department of Biophysics, Kyoto University, Kyoto, Japan.
1987-1991: Associate Research Biochemist, Cancer Research Institute, UCSF, San Francisco.
1986 Nov-Dec: Visiting Professor, CNR Institute of Cybernetics and Biophysics, Genova, Italy.
1985-1987: Assistant Adjunct Professor, Department of Pharmaceutical Chemistry, UCSF, San Francisco.
1981-1987: Assistant Research Biochemist, Cancer Research Institute, UCSF, San Francisco.
1981-l983: Assistant Research Biochemist, Research Laboratory, Children's Hospital Medical Center, Oakland, California
Gene therapy of oral cancer
Eliminating HIV-infected cells
Targeted non-viral vectors for gene delivery
Therapy of oral Candida and Porphyromonas infections
Any other information:
Refereeing for Journals
AAPS Journal; AIDS; Antimicrobial Agents and Chemotherapy; Antiviral Research; Applied and Environmental Microbiology; Archaea; Archives of Biochemistry and Biophysics; Archives of Microbiology; Biochemical Journal; Biochemistry; Biochimica et Biophysica Acta; Biological Procedures Online; Biology of the Cell; BioMed Central Biotechnology; BioMed Central Cancer; Biomacromolecules; Biomaterials; Biophysical Journal; BioTechniques; Biotechnology and Bioengineering; Biotechnology Progress; Breast Cancer Research and Treatment; Cellular and Molecular Biology Letters; Chemico-Biological Interactions; Chemistry and Physics of Lipids; Clinical Vaccine Immunology; Colloids and Surfaces B; Current Drug Delivery; Current Pharmaceutical Design; DNA and Cell Biology; Environmental Science and Technology; European Journal of Pharmaceutics and Biopharmaceutics; Expert Opinion on Drug Delivery; Expert Reviews on Anti-Infective Therapy; FEBS Letters; Future HIV Therapy; Future Lipidology; Glycobiology; International Journal of Artificial Organs; International Journal of Pharmaceutics; Journal of Antimicrobial Chemotherapy; Journal of Bionanoscience; Journal of Colloid and Interface Science; Journal of Controlled Release; Journal of Bionanoscience; Journal of Biotechnology; Journal of Dental Education; Journal of Drug Delivery Science and Technology; Journal of Clinical Investigation; Journal of Gene Medicine; Journal of Histochemistry and Cytochemistry; Journal of Inorganic Biochemistry; Journal of Lipid Research;Journal of Liposome Research; Journal of Materials Science: Materials in Medicine; Medicinal Chemistry Communications; Journal of Membrane Biology; Journal of Microencapsulation; Journal of Pharmacology and Experimental Therapeutics; Journal of Pharmaceutical Sciences; The Journal of Physical Chemistry; Journal of Virology; Letters in Drug Design and Discovery; Life Sciences; Molecular Biology Reports; Molecular Cancer Therapeutics; Molecular Membrane Biology; Molecular Pharmaceutics; Molecular Therapy; Nanomedicine: Nanotechnology, Biology and Medicine; Nature Biotechnology; Pharmaceutical Research; Pharmaceuticals; Proceedings of the National Academy of Sciences USA; Public Library of Science One (PLoS One); Surfactants in Solution; Therapeutic Delivery; Turkish Journal of Physics; Vaccine; Virus Research
National Institutes of Health 2R44AI066442-02 “Novel mycobacterial translocase I inhibitors - a new class of anti-TB drugs” (Collaborator; V. Reddy, PI) Total direct costs: $124,349; total indirect costs: $32,400 (1/9/2008-10/31/2010)
National Institutes of Health HL-73668, "Efficacy of Liposomal Budesonide in Experimental Asthma,"(Co-PI; K. Konduri, PI) Total direct costs: $29,790 (7/2004-4/2005)
US-Israel Binational Agricultural Research and Development Agency, "Prolonged Bitter Taste in Agricultural Products: Mechanisms and Inhibition Using a Multi-Disciplinary Approach," (Co-PI; M. Naim, PI) Total direct costs: $51,000 (10/2002-9/2004)
Envirosystems, Inc., "Antimicrobial Activity of Ecotru in a Dental Setting," (PI), Total costs: $16,506 (4/2002-12/2002)
Medical College of Wisconsin, "Liposomal Corticosteroids for Asthma Therapy" (PI of subcontract), Total costs: $11,188 (1/2002-12/2002)
University of the Pacific Research Funds, "Luminometer to Detect Gene Expression for Gene Therapy" (PI) Total costs: $3,000 (3/2001-2/2002)
University of Illinois at Chicago, "Liposomal Budesonide" (PI of subcontract) Total direct costs: $7,000 (1/2000-12/2001)
NATO, Scientific and Environmental Affairs Division, "Strategies to Enhance Gene Delivery: Overcoming the Nuclear Barrier" (Co-PI) Total direct dosts: $7,000 (1/2000-12/2000)
SEQUUS Pharmaceuticals, "Anti-HIV Effect of Liposomal Amphotericin B" (PI) Total costs: $10,080 (1/1997-12/1998)
SEQUUS Pharmaceuticals, "Anti-HIV Activity of CD4-Liposomes" (PI) Total Costs: $17,608 (11/1996-10/1997)
National Institutes of Health U01-AI35231, "AIDS Therapy via Liposome-Mediated Gene Delivery" (PI; G. Harrison, Program Director) Annual Direct Costs: $118,769 (1/1994-12/1996)
National Institutes of Health R01-AI33833, "Targeted Therapy of Mycobacterium avium Infections" (Co-PI; P. Gangadharam, PI) Direct costs per year: $98,608 (9/1993-9/1996)
National Institutes of Health R01-AI32399, "Drug Targeting to HIV-Infected Cells" (PI) Annual Direct Costs: $123,194 (8/1993-7/1996)
Universitywide AIDS Research Program R91UP002, "Drug Targeting to HIV-Infected Cells" (PI) Total Direct Costs: $90,000 (1/1992-12/1993)
SEQUUS Pharmaceuticals, "CD4-Liposomes for Targeting to HIV-Infected Cells" (PI) Total Direct Costs: $50,000 (3/1989-3/1991)
National Institutes of Health R01-25534, "Kinetics and Mechanisms of Virus-Cell Membrane Fusion" (PI) Annual Direct Costs: $157,254 (2/1988-1/1993)
NATO Scientific Affairs Division, "Fusion Activity of Lipid Enveloped Viruses" (Co-investigator; M. C Pedroso de Lima, PI) Total Direct Costs: $14,000 (7/1990-7/1994)
National Institutes of Health R01-28117, "Mechanisms of Membrane Fusion" (Co-investigator; D. Papahadjopoulos, PI) Total direct costs: $610,515 (2/1985-1/1990)
Universitywide Task Force on AIDS, "Liposome-Mediated Therapy of Mycobacterium avium-intracellulare Infections" (PI) Annual direct costs: $72,309 (7/1986-6/1990)
American Heart Association, "Role of Cholesterol in Membrane Fusion" (PI) Annual direct costs: $30,000 (10/1983-9/1986)
G. Steffan, I.I. Salem & N. Düzgüne?. Water-soluble iminophenazine derivative-containing pharmaceutical complexes, their preparation and use. German Patent DE 198 14814 A1.
G. Steffan, H.-J. Galla, N. Düzgüne? & C. Henke. Sterol-conjugated, anionic cyclodextrin derivative and its use in drug formulations. German Patent DE 198 14815 C2.
N. Düzgüne?, S. Simões, V. Slepushkin & M. C. Pedroso de Lima. Non-ligand polypeptide and liposome complexes as intracellular delivery vehicles. US Patent US 6,245,427 B1.
What I think of the idea behind WebmedCentral:
WebmedCentral is a novel approach to publishing. I have always believed that referee reports of papers and grant applications should stand on their scientific merit, and not hide behind anonymity. Review of a paper or grant application should indicate the scientific basis of the criticism, and should be devoid of personal bias.