Review articles

By Dr. Balasubramanian Thiagarajan , Dr. Karthikeyan Arjunan
Corresponding Author Dr. Balasubramanian Thiagarajan
Department of otolaryngology, Stanley Medical College, Chennai Tamilnadu, Otolaryngology online, sreemagal, 20 officers colony rajaram metha nagar chennai India 600029 - India 600029
Submitting Author Dr. Balasubramanian Thiagarajan
Other Authors Dr. Karthikeyan Arjunan
Otolaryngology Stanley Medical College, - India


Hyperbaric oxygen therapy, otolaryngology uses

Thiagarajan B, Arjunan K. Hyperbaric Oxygen therapy Concepts and Myths. WebmedCentral OTORHINOLARYNGOLOGY 2012;3(4):WMC003309
doi: 10.9754/journal.wmc.2012.003309

This is an open-access article distributed under the terms of the Creative Commons Attribution License(CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Submitted on: 27 Apr 2012 02:02:23 PM GMT
Published on: 28 Apr 2012 11:09:04 AM GMT


Hyperbaric oxygen therapy is defined as administration of 100% oxygen to a patient placed inside a chamber pressurised to greater than 1 atmosphere at sea level 1. Local application of oxygen under high pressure without completely enclosing the patient is not considered to be hyperbaric oxygen therapy.


Hyperbaric oxygen therapy is not a new concept. This concept historically can be traced back to 1600. The first hyperbaric chamber was constructed by British clergyman Henshaw 2. He called the chamberdomicilium. This chamber was pressurized and depressurized using bellows. In 1670 Robert Boyle observed that the eye of a snake could express gas bubble through the cornea. On observing this phenomenon he concluded that tissues undergoing rapid decompression causes expression of bubbles of previously dissolved gases. This prompted him to formulate the famous Boyles law, which states “At constant temperature the volume and pressure of gas are inversely proportional.”

Henshaw used his domicilium to facilitate digestion, to facilitate breathing, prevention of respiratory infections. This chamber provided only atmospheric air under high pressure as oxygen was not discovered till 1773 by Carl Wilhem Sheeley. The term oxygen was coined by Antoine Lavoiser only in 1777. 4French surgeon Fontaine was the first to build a pressurised mobile operating room in 1879 3. He used Nitrous oxide as anaesthetic agent and beleived hyperbaric oxygen chambers helped in better patient anesthesia.
Orwill Cunningham Professor of anesthesia (1928) ran a Hyperbaric oxygen hospital in Lawrence Kansas. He christened it as “Steel Ball Hospital”. This so called hyperbaric oxygen hospital was six stories high and 64 feet in diameter. This hospital could achieve pressure levels of 3 atmospheres 3. Cunningham claimed excellent results and he used this chamber to treat patients with spanish influenza 4which was rampant during the first world war in United states. Two years later this hospital was closed down and scrapped for lack of scientific evidence.

Military found a unique use for hyperbaric oxygen chambers. Paul Bert demonstrated excess oxygen saturation caused grand mal seizures in humans. Navy used this chamber to quantify different exposure times to oxygen at varying depths that could lead to seizures in humans.

From 1930 onwards oxygen supplementation was used to manage acute decompression sickness. Oxygen when respired at very high pressures manages to displace nitrogen accumulated from the tissue. Use of hyperbaric oxygen considerably helps to reduce the time taken to treat decompression sickness. In 1935, Behnke showed nitrogen to be the common cause of narcosis in humans during decompression sickness. Behnke and Shaw successfully used hyperbaric oxygen to treat decompression sickness.


1. Arterial air or gas embolism
2. Acute blood loss anaemia
3. Carbon monoxide poisoning, cyanide poisoning, and smoke inhalation
4. Compromised skin grafts and flaps
5. Crush injury
6. Decompression sickness
7. To facilitate enhanced wound healing
8. Gas gangrene
9. Necrotising soft tissue infections
10. Radiation necrosis: Osteoradionecrosis, soft tissue radionecrosis, caries in radiated bones
11. Refractory osteomyelitis
12. Refractory mycosis
13. Thermal burns
14. Radiation induced soft tissue necrosis: Hyperbaric oxygen therapy promotes neovascularisation. Hypoxia is corrected and wound heals faster.
15. Osteoradionecrosis: Hyperoxygenation and neovascularisation helps in treating this difficult condition. Hyperbaric oxygen treatment is an effective adjuvant to antibiotics in managing this condition.
16. Prevention of mandibular osteoradionecrosis
17. In treating necrotising soft tissue infections
18. In management of malignant otitis externa
19. Can be used in management of fungal infections of head and neck. This has a proven value as an adjunct to the regular antifungal agents.
20. Managment of acute blood loss anaemia
21. Can be used to salvage compromised skin grafts and flaps
22. Can be used as an adjunct in the management of patients with burns
23. Can be used to manage air or gas embolism

Mechanism of Action

1. Hyperoxygenation – is achieved by first completely saturating the hemoglobin and then by increasing the amount of oxygen dissolved in the plasma. This increases the distance of oxygen diffuses away from the capillaries. This is three times higher than under normal conditions.
2. Vasoconstriction – Vasoconstriction caused by hyperbaric oxygen therapy does not reduce oxygenation, on the contrary it has a benefical effect of reducing edema in skin grafts and flaps.
3. Anitmicrobial activity – Hyperbaric oxygen therapy is bactericidial to obligate anaerobes. It also increases the ability of polymorphs to kill bacteria. It is also known to inhibit and inactivate the toxins released by clostridium welchi, thereby preventing gas gangrene.
4. Pressure effects – Hyperbaric oxygen is used to reduce the size of gas bubble. Because of this feature it is the treatment of choice in decompression sickness.
5. Neovascularisation
6. Fibroblastic proliferation
7. Improved functioning of osteoblasts and osteoclasts
8. Increased red cell deformability

Gamow bag5

In 1990 Gamow devised a portable hyperbaric chamber which could generate pressures less than 1.5 Atmospheres. This bag is still being used by high altitude climbers to combat low air pressures at high altitudes.


1. Middle ear barotrauma – This can occur if the patient is unable to equalise the middle ear pressure. This complication can be best avoided by the use of systemic and topical nasal decongestants before proceeding with hyperbaric oxygen therapy. If this condition occurs then myringotomy should be resorted to without hesitation.
2. Myopia – This is temporary and reverses back to normal after cessation of treatment.
3. Pneumothorax – can occur if decompression occur too rapidly or if the patient holds the breath during decompression.
4. Oxygen induced seizures – This complication is very rare. These patients should be given vitamin E before treatment to protect against superoxide radicals. Oxygen induced seizures can be stopped by allowing the patient to breath normal air. Oxygen induced seizures are not known to cause permanent neurological sequlae.

How to administer hyperbaric oxygen?
Hyperbaric oxygen is administered by placing the patient inside oxygen chambers. Two types of chambers are commonly used for hyperbaric oxygen therapy. 1. Monoplace and 2. Multiplace chambers. In both these chambers facilities are provided for monitoring the various vital body parameters like heart rate, blood pressure and blood oxygen levels etc. Facilities are provided for intravenous administration of drugs and fluids.

Monoplace chamber: Here 100% pressurised oxygen is utilized. Patient alone is placed in this type of chamber. There is no space for attendants. The patient is placed alone inside this chamber. This chamber is hence not useful in critically ill patients.

Multiplace chamber: These chambers are pressurised with air. Patients inside this chamber are administered 100% oxygen via a face mask or hood. These chambers allow one or more attendants inside them. This feature is advantageous in treating seriously ill patients.

Regardless of the type of chamber used the following factors must be considered:

1. The amount of pressure used.
2. Duration of the treatment.
3. How often the treatment is repeated.

To avoid oxygen toxicity the treatment duration should not exceed 120 minutes. The safe range being 90 – 120 minutes. The pressure used is about 2 atmospheres. When a patient’s condition require multiple hyperbaric oxygen treatments per day, a minimum duration of 6 hours between them is a must.


Absolute contraindications:
1. Pneumothorax
2. Pulmonary damage

Relative contraindications:
1. Pulmonary bulla
2. Seizure disorder
3. Patients on high dose of steroids
4. Chronic obstructive pulmonary disorders
5. Recent myocardial infarction
6. Patients with claustrophobia


2. Henshaw IN, Simpson A.Compressed Air as a Therapeutic Agent in the Treatment of Consumption, Asthma, Chronic Bronchitis and Other Diseases. Edinburgh: Sutherland and Knox; 1857.
3. Kindwall E, Whelan H.Hyperbaric Medicine Practice. 2Nd ed. Flagstaff, AZ: Best Publishing Company; 2004:chap 1, 18, 19, 20, 25, 29, 30.
5. Auerbach, Paul S; Donner, Howard J.; Weiss, Eric A. (2008). Field Guide to Wilderness Medicine, 3rd Edition. Mosby Elsevier. ISBN 978-1-4160-4698-1.

Source(s) of Funding

This article did not receive any external funding

Competing Interests

No competing interest


This article has been downloaded from WebmedCentral. With our unique author driven post publication peer review, contents posted on this web portal do not undergo any prepublication peer or editorial review. It is completely the responsibility of the authors to ensure not only scientific and ethical standards of the manuscript but also its grammatical accuracy. Authors must ensure that they obtain all the necessary permissions before submitting any information that requires obtaining a consent or approval from a third party. Authors should also ensure not to submit any information which they do not have the copyright of or of which they have transferred the copyrights to a third party.
Contents on WebmedCentral are purely for biomedical researchers and scientists. They are not meant to cater to the needs of an individual patient. The web portal or any content(s) therein is neither designed to support, nor replace, the relationship that exists between a patient/site visitor and his/her physician. Your use of the WebmedCentral site and its contents is entirely at your own risk. We do not take any responsibility for any harm that you may suffer or inflict on a third person by following the contents of this website.

0 reviews posted so far

0 comments posted so far

Please use this functionality to flag objectionable, inappropriate, inaccurate, and offensive content to WebmedCentral Team and the authors.


Author Comments
0 comments posted so far


What is article Popularity?

Article popularity is calculated by considering the scores: age of the article
Popularity = (P - 1) / (T + 2)^1.5
P : points is the sum of individual scores, which includes article Views, Downloads, Reviews, Comments and their weightage

Scores   Weightage
Views Points X 1
Download Points X 2
Comment Points X 5
Review Points X 10
Points= sum(Views Points + Download Points + Comment Points + Review Points)
T : time since submission in hours.
P is subtracted by 1 to negate submitter's vote.
Age factor is (time since submission in hours plus two) to the power of 1.5.factor.

How Article Quality Works?

For each article Authors/Readers, Reviewers and WMC Editors can review/rate the articles. These ratings are used to determine Feedback Scores.

In most cases, article receive ratings in the range of 0 to 10. We calculate average of all the ratings and consider it as article quality.

Quality=Average(Authors/Readers Ratings + Reviewers Ratings + WMC Editor Ratings)