Tinospora cordifolia is one of the constituents of several ayurvedic preparations used in general debility, dyspepsia, fever and urinary diseases. The stem is bitter, stomachic, diuretic, stimulates bile secretion, causes constipation, allays thirst, burning sensation, vomiting, enriches the blood and cures jaundice. The extract of its stem is useful in skin diseases. The root and stem of T. cordifolia are prescribed in combination with other drugs as an anti-dote to snake bite and scorpion sting Dry barks of T. cordifolia has anti-spasmodic, anti- pyretic, anti-allergic , anti-inflammatory and anti-leprotic properties.
Tinospora cordifolia (TC) is a large extensively spreading glabrous, perennial deciduous twiner with succulent stems and papery bark; leaves simple, alternate, cordate, entire, 7-9 nerved; flowers in clusters, female flowers usually solitary; fruits drupes, red when ripe. The surface of the stems appears to be closely studded with warty tubercles and the surface skin is longitudinally fissured. On removal of the surface skin the dark greenish mucilaginous stem is seen. The plant is sometimes cultivated for ornamental value and is propagated by cuttings. The leaves afford a good fodder for cattle.
Ayurvedic literature quotes guduchi as a constituent of several compound preparations, used in general debility, dyspepsia, fever and urinary diseases. It has multiple actions like; stem is a bitter stomachic; stimulates bile secretion; causes constipation; tonic; allays thirst, fever, burning sensation, prevents vomiting; diuretic; enriches the blood; cures jaundice; useful in skin diseases; the juice is useful in diabetes, vaginal and urethral discharges, low fevers, and enlarged spleen (Ayurveda). The root and stem are prescribed in combination with other drugs as an antidote to snake bite and scorpion sting. An infusion of the powdered stem is used as an alternative and tonic and has enjoyed the reputation among ancient Hindu writers of being an aphrodisiac.
Various pharmacological actions and medicinal uses of the different parts of plant are well reported in the ancient literature. Biological activities of the crude extracts as well as its different fractions from leaf, root, stem bark and fruit have been reported. The biological activities of crude extract(s) of various part(s) of guduchi on different animal models as well as on human beings have been discussed in the following below
Pet.Ether Petroleum ether
1. Dhuley JN. Effect of some Indian herbs on macrophage functions in ochratoxin A treated mice. Journal of Ethnopharmacology. 1997; 58: 15-20.
2. Thatte UM , Dahanukar SA. Comaparative study of immunomodulating activity of Indian Medicinal Plants, Lithium carbonate and glucan. Methods and findings in experimental and clinical pharmacology, 1988; 10(10): 639-644.
3. Thatte UM, Dahanukar SA. Immunotherapeutic modifications of experimental infection by Indian Medicinal Plants. Phytotherapy Research. 1989; 3: 43-49.
4. Mathew S, kuttan G. Antioxidant activity of Tinospora Cordifolia and its usefulness in the amelioration of cyclophosphamide induced toxicity. Journal of Experimental and Clinical Cancer Research. (1997); 16(4): 407-411.
5. Grover JK , Vats V. Amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plants (Eugenia jambolana, Mucurna Pruriens and Tinospora cardifolia) extracts. Indian Journal of Experimental Biology. 2002; 40: 273-276.
6. Wadood N et al., Effetc of Tinospora cordifolia on blood glucose and totallipid levels of normal and alloxan-diabetic rabbits. Planta Med. 1992; 58: 131-136.
7. Prince PSM, Menon VP. Short communications : Hypogycaemic and Hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytotherapy Research. 2003; 17: 410-413.
8. Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C. Screeing of Indian Plants For Biological Activity : Part I*. Indian Journal of Experimental Biology. 1968; 6: 232-245.
9. Raghunathan K, Sharma PV. Effect of Tinospora cordifolia Miers (guduchi) on adrenaline induced hyperglycaemia. Jour. Res. Ind. Med. 1969 ; 4(1): 59-62.
10. Bishayi B, Roychowdhury S, Ghosh S, Sengupta M. Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCL4 intoxicated mature albino rats. The journal of Toxicological Sciences. 2002; 27(3): 139-146.
11. Nagarkatti DS etal., Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage. Journal of Postgraduate Medicine. 1994; 40(2): 65-67.
12. Jeyachandran R etal., Antibacterial activity of stem extracts of Tinospora cordifolia (Wild.) Hook.f & Thomson. Ancient sciences of life. 2003; XXIII (1) july, August, September: 40-43.
13. Gupta KC , Viswanathan R. Antituberculous substances from plants. Antibiotics and Chemotherapy. 1956; 6: 194-195.
14. Dahanukar SA etal., Immunotherapeutic modification by Tinospora cordifolia of abdominal sepsis induced by caecal ligation in rats. Indian Jornal of Gastroenterology. 1988; 7(1): 21-23.
15. Ikram M etal., Antipyretic studies on some indigenous Pakistani medicinal Plants : II. Journal of Ethnopharmacology. 1987; 19: 185-192.
16. Vedavathy S, Rao KN. Short communications : Antipyretic activity of six indigenous medicinal plants of Trimula Hills, Andhra Pardesh, India. Journal of Ethnopharmacology. 1991; 33: 193-196.
17. Sarma DNK etal., Effetc of Tinospora cordifolia on brain neurotransmitters in stressed rats. Fitoterapia. 1995a; LXVI(5): 421-422.
18. Sarma DNK etal., Short communication: Antiulcer activity of Tinospora cordifolia Miers and Centella asiatica Linn extracts. Phytotherapy Research. 1995b; 9: 589-590.
19. Patil M etal., Antistress activity of Tinospora cordifolia (wild) Miers. Indian Drugs. 1997; 34(4): 211-215.
20. Pendse VK etal., Anti-inflammatory, immunosuppressive and some related pharmacologicalactions of the water extract of Tinospora cordifolia: A preliminary report. Ind. J. Pharmac. 1977; 9(3): 221-224.
21. Gulati OD, Pandey DC. Anti-inflammatory activity of Tinospora cordifolia. Rheumatism. 1982; 17(2): 76-83.
22. Sherlekar RR etal., XXXIII Annual Conference of the Indian Pharmacological Society, Gandhinagar, December 28-30, 2000 Abstracts Part- II, no. 95. In-vitro effect of Tinospora cordifolia on leukemic cell proliferation. Indian Journal of Pharmacology. 2001; 33: 130.
23. Mathew S, Kuttan G. Immunomodulatory and antitumour activities of Tinospora cordifolia. Fitoterapia. 1997; 70: 35-43.
24. Prince PSM, Menon VP. Short communications, Antioxidant action of Tinospora cordifolia roots in experimental diabetes. Journal of Ethnopharmacology. 1999; 65: 277-281.
25. Prince PSM, Menon VP. Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats. Phytotherapy Research. 2001; 15: 213-218.
26. Maryamma KI etal., Ameliorating effect of Amrutha (Tinospora cordifolia) in aflatoxicosis of ducks. Journal of Veterinary and Animal Sciences. 1990; 21(2): 93-96.
27. Goel HC etal., Radioprotective potential of an herbal extract of Tinospora cordifolia. Journal of Radiation Research. 2004; 45: 61-68.
28. Pahadiya S, Sharma J. Short communication: Alteration of lethal effects of gamma rays in Swiss albino mice by Tinospora cordifolia. Phytotherapy Research. 2003; 17: 552-554.
Source(s) of Funding
This article has been downloaded from WebmedCentral. With our unique author driven post publication peer
review, contents posted on this web portal do not undergo any prepublication peer or editorial review. It is
completely the responsibility of the authors to ensure not only scientific and ethical standards of the manuscript
but also its grammatical accuracy. Authors must ensure that they obtain all the necessary permissions before
submitting any information that requires obtaining a consent or approval from a third party. Authors should also
ensure not to submit any information which they do not have the copyright of or of which they have transferred
the copyrights to a third party.
Contents on WebmedCentral are purely for biomedical researchers and scientists. They are not meant to cater to
the needs of an individual patient. The web portal or any content(s) therein is neither designed to support, nor
replace, the relationship that exists between a patient/site visitor and his/her physician. Your use of the
WebmedCentral site and its contents is entirely at your own risk. We do not take any responsibility for any harm
that you may suffer or inflict on a third person by following the contents of this website.