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Skillman Professor and Director of Pediatric Ophthalmology and Adult Strabismus University of Michigan/ Kellogg Eye Institute
1000 Wall St United States of America 48105
Speciality: Pediatric Ophthalmology & Adult StrabismusSpecialty Interests* Diagnosis and treatment of strabismus and amblyopia in adults and children, lacrimal disorders, glaucoma, cataracts, inherited eye diseases in childrenMedical School, Johns Hopkins University, 1974Residencies* Pediatrics, Children's Hospital Boston, Harvard University, 1977* Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, 1981Fellowships* Pediatric Ophthalmology and Ophthalmic Genetics, Wilmer Eye Institute, Johns Hopkins University, 1978* Pediatric Ophthalmology and Adult Strabismus, Children's National Medical Center, 1982Research Focus* Tissue culture and cell biology of ocular tissue, retinal degeneration, diabetic retinopathy, ocular inborn errors in metabolism, biochemical genetics, surgical and nonsurgical therapy for strabismus, amblyopia, congenital cataract and pediatric glaucoma
* Skillman Professor of Pediatric Ophthalmology* Professor, Ophthalmology and Visual Sciences* Professor, Pediatrics and Communicable Diseases* Director of Pediatric Ophthalmology and Adult Strabismus* Director of Pediatric Ophthalmology at CS Mott Children's Hospital
Factors Influencing Abnormal Retinal Cell Proliferation in Diabetes, Retinal Detachment and Other Eye DisordersAbnormal cell growth results in blinding complications associated with certain eye diseases and conditions, including diabetes, retinitis pigmentosa and retinal detachment. Cells may form colonies, change shape, and/or migrate to other parts of the eye, resulting in scarring and poor vision. Surgery can often alleviate the symptoms. Dr. Monte Del Monte investigates ways to find simpler, non-surgical treatments for this problem. Many growth factors influence the extent of cell growth and differentiation in the retina. One of these growth factors is retinoic acid. Although we do not understand how, retinoic acid is known to limit cell growth and differentiation in human retinal pigment epithelium and other retinal tissues. Dr. Del Monte's hypothesis is that cyclic AMP-dependent protein kinase A (PKA) mediates the action of retinoic acid. His experiments involving protein kinase A inhibitors in cell culture substantiate his hypothesis. Fibroblast growth factor (FGF) also stimulates human retinal pigment epithelium proliferation. He has found, however, that in the presence of retinoic acid, this stimulation does not occur. Currently, experiments are under way to determine the role of FGF receptors in retinoic acid-mediated growth stimulation. Understanding this biochemistry may lead to development of drug treatments that target the role of retinoic acid, PKA, FGF, and other growth factors in abnormal ocular tissue development. In addition, collaborating with Dr. Douglas Greene of the Michigan Diabetes Training Center, Dr. Del Monte is investigating the effects of hyperglycemia on aldose reductase and myoinositol metabolism in RPE cell lines in culture. Aldose reductase is induced in the presence of high levels of glucose. The enzyme, which converts glucose to sorbitol, increases cytoplasmic sorbitol levels. There is an associated depletion of myo-inositol. Through phosphoinositide signaling pathways, changes in these metabolites lead to tissue damage due to alterations in membrane function, signal transduction, and nerve conductance. Better understanding of these mechanisms will lay the groundwork for future treatments of diabetic retinopathy and neuropathy.
Selected Publications:* Kothary PC, Badhwar J, Weng C, Del Monte MA. Impaired intracellular signaling may allow up-regulation of CTGF-synthesis and secondary peri-retinal fibrosis in human retinal pigment epithelial cells from patients with age-related macular degeneration. Adv Exp Med Biol 2010;664:419-428.Weng CY, Kothary PC, Verkade AJ, Reed DM, Del Monte MA. MAP kinase pathway is involved in IGF-1-stimulated proliferation of human retinal pigment epithelial cells (hRPE). Curr Eye Res 2009;34:867-876.* Nyong'o OL, Del Monte MA. Childhood visual impairment: normal and abnormal visual function in the context of developmental disability. Pediatr Clin North Am 2008;55:1403-1415.* Eibschitz-Tsimhoni M, Tsimhoni O, Archer SM, Del Monte MA. Effect of axial length and keratometry measurement error on intraocular lens implant power prediction formulas in pediatric patients. J Aapos 2008;12 (2):173-176.* Kothary PC, Del Monte MA. A possible impaired signaling mechanism in human retinal pigment epithelial cells from patients with macular degeneration. Adv Exp Med Biol2008; 613:269-275.* Del Monte MA, O'Keefe M, Johnson A. Immediate postoperative strabismus management. J Pediatr Ophthalmol Strabismus 2007;44:330-332.* Kemper AR, Gurney JG, Eibschitz-Tsimhoni M, Del Monte M. Corrective lens wear among adolescents: findings from the National Health and Nutrition Examination Survey. J Pediatr Ophthalmol Strabismus 2007;44:356-362.* Eibschitz-Tsimhoni M, Archer SM, Furr BA, Del Monte MA. Current Concepts in the Management of Concomitant Exodeviations. Compr Ophthalmol Update 2007;8:213-223.* Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Effect of axial length and keratometry measurement error on intraocular lens implant power prediction formulas in pediatric patients. J AAPOS 2007 [in press].* Eibschitz-Tsimhoni M, Archer SM, Del Monte MA, Furr BA . Current concepts in the management of concomitant exodeviations. Comp Ophthalmol Update 2007 [in press].* Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Intraocular lens power calculation in children. Surv Ophthalmol 2007;52:474-482.* Eibschitz-Tsimhoni M, Tsimhoni O, Archer SM, Del Monte MA.Discrepancies between intraocular lens implant power prediction formulas in pediatric patients. Ophthalmology2007;114:383-386.* Del Monte M, Hertle R. Extraocular muscle surgery for nystagmus. J Pediatr Ophthalmol Strabismus 2006;43:200-204.* Kothary PC, Lahiri R, Kee L, Sharma N, Chun E, Kuznia A, Del Monte MA. Pigment epithelium-derived growth factor inhibits fetal bovine serum stimulated vascular endothelial growth factor synthesis in cultured human retinal pigment epithelial cells.Adv Exp Med Biol 2006;572:513-518.* Del Monte MA. Sturge-Weber syndrome. In:Fraunfelder FT, Roy H, eds. Current Ocular Therapy, 6th ed. Philadelphia:WB Saunders, 2006.* Peters E, Del Monte MA. The pediatric eye examination. In: Reddy V, ed. DeGowin's Pediatric Diagnostic Examination. Philadelphia:McGraw Hill, 2006.* Gupta B, Del Monte M. Strabismus associated with orbital fractures. In: Holck DEE, Ng JD, eds. Evaluation and Treatment of Orbital Fractures: a Multidisciplinary Approach.Philadelphia :Elsevier Saunders, 2006, chap 35.* Kothary PC, Lahiri R, Kee L, Sharma N, Chun E, Kuznia A, Del Monte MA. Pigment epithelial-derived growth factor inhibits fetal bovine serum stimulated vascular endothelial growth factor synthesis in cultured human retinal epithelial cells. In: Hollyfield JG, Anderson RE, LaVail MM, eds. Retinal Degenerative Diseases. New York:Springer, 2006, chap 71.* Kothary, PC, Del Monte, MA. High glucose modulates growth factor action in human retinal pigment epithelial cells. In: S.G. Pandalai, ed., Recent Research Developments in Cellular Biochemistry, Vol 2. India:Transworld Research Network 2005, pgs 1-16.* Del Monte MA, Archer SM. Surgery to correct Duane syndrome and Brown syndrome. In: Tasman W, Jaeger EA, eds. Clinical Ophthalmology, Vol 6. Philadelphia : Lippincott, Williams & Wilkins, 2005, chap 96.* Archer SM, Musch DC, Wren PA, Guire KE, Del Monte MA. Social and emotional impact of strabismus surgery on quality of life in children. J AAPOS 2005;9:148-151.* Kothary PC, Pauuw JD, Bansal AK, Grace CC, Del Monte MA. Inhibition of growth factor stimulated STAT3 bt AG490 in human retinal pigment epithelial cells. In: Proceedings of 5th International Symposium on Ocular Pharmacology and Therapeutics. Italy:Medimond S.r.l., 2004, pgs 237-241.* Yang MB, Pou-Vendrell CR, Archer SM, Martonyi EJ, Del Monte MA. Vertical rectus muscle surgery for nystagmus patients with vertical abnormal head posture. J AAPOS2004;8:299-309.* Kothary, PC, Del Monte, MA . Growth factors, and their receptors and inhibitors with a special focus on human retinal pigment epithelial cells and the eye. In: S.G. Pandalai, ed., Recent Research Developments in Cellular Biochemistry, Vol 1. India:Transworld Research Network, 2003, pgs 99-116.* Eibschitz-Tsimhoni M, Lichter PR, Del Monte MA, Archer SM, Musch DC, Schertzer RM, Moroi SE. Assessing the need for posterior sclerotomy at the time of filtering surgery in patients with Sturge-Weber syndrome. Ophthalmology 2003;110:1361-1363.* Superstein R, Archer SM, Del Monte MA. Minimal myopic shift in pseudophakic versus aphakic pediatric cataract patients. J AAPOS 2002;6:271-276.* Del Monte, M.A., Eibschitz-Tsimhoni, M.; Sturge-Weber syndrome. In: Fraunfelder, F.T., and Roy, H. (ed): Current Ocular Therapy. W.B. Saunders Co., Philadelphia, PA, 2000) pp. 198-202.* Brown S.M., Archer, S.A., and Del Monte, M.A.; Stereopsis and binocular vision after surgery for unilateral infantile cataract, J AAPOS, 3:1-5, 1999.* Kusaka, K. Kothary, P.C., and Del Monte, M.A.; Modulation of basic fibroblast growth factor effect by retinoic acid in cultured retinal pigment epithelium, Curr Eye Res, 17:524-530, 1998.* Ueda M, Masu Y, Ando A, Maeda H, Del Monte MA, Uyama M, et al. Prevention of ornithine cytotoxicity by proline in human retinal pigment epithelial cells. IOVS1998;39:820-7.* Kusaka K, Kothary PC, Del Monte MA. Modulation of basic fibroblast growth factor effect by retinoic acid in cultured retinal pigment epithelium. Curr Eye Res 1998;17:524-30.* Brooks, S.E., Riberio, G. deB. Archer, S.M., Elner, V.M., and Del Monte, M.A.: Fat adherence syndrome in a rabbit model and treatment with intraoperative mitomycin C. J Pediatr Ophthalmol Strab, 33:21-27, 1996.* Wright, K.W., Buckley E.G., Del Monte, M.A., Ellis, F.D., Ellis, G., Mets, M.B., and Stone, E.M.: Pediatric Ophthalmology and Strabismus. Mosby-Year Book, Inc., St Louis, MO, 1995.* Miyamoto Y, Del Monte MA. Na+ -dependent glutamate transporter in human retinal pigment epithelial cells. IOVS 1994;35:3589-98.* Del Monte, M.A., Greenwald, M.J., Mets, M.B., Wilson, M.E., and Wright, K.W.: Pediatric Ophthalmology and Strabismus: Basic and Clinical Science Course. American Academy of Ophthalmology publisher, San Francisco CA, 1994.* Henry DN, Del Monte M, Greene DA, Killen PD. Altered aldose reductase gene regulation in cultured human retinal pigment epithelial cells. J Clin Invest 1993;92:617-23.* Del Monte, M.A.: Atlas of Pediatric Ophthalmology and Strabismus Surgery, Churchill Livingston Publisher, NY, NY 1993.* Del Monte MA, Rabbani R, Diaz TC, Latimer SA, Nakamura J, Brennan MC, et al. Sorbitol, myo-inositol, and rod outer segment phagocytosis in cultured hRPE cells exposed to glucose: in vitro model of the myo-inositol depletion hypothesis of diabetic complications. Diabetes 1991;40:1335-45.
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