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MD,PhD Pathology, University of Pittsburgh
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EDUCATION and TRAININGUNDERGRADUATE:1. 1982-1988: Tanta Faculty of Medicine Tanta University, EgyptGRADUATE/POST-GRADUATE:1. 1993- 1995: Dept. of Microbiology&Immunology Institute of Medical Science; University of Toronto; Toronto, Canada2. 1996- 2000: Dept. of Microbiology&Immunology; University of Saskatchewan Saskatoon, SK, Canada
POSTGRADUATE:1. 1989-1990: Tanta University Hospitals Tanta, Egypt, Intern Medicine 2. 1991- 1992: Tanta University Hospitals Tanta,Egypt, Resident Diagnostic (Incomplete) Radiology3. 1992-1993: Dept. of Medical Microbiology post-doct fellow Turku University,Finland Microbiology4. 2000- 2002: Department of Pathology U. of Texas Medical Branch Galveston, TX Atraining, 5. 2002: Clinical Microbiology
SERVICE: COMMITTES NATIONAL Member of the American Society for Rickettsiology 2010-Meeting Planning Committee INTERNATIONAL Abstracts and Oral Presentations Selection CommitteINSTITUTION:1. October 2008-2011: Member, Institution Safety Committee Meharry Medical College,Nashville, TN.2. August 2010-2011: Member, Student Research Day Speaker Selection Committee Meharry Medical College, Nashville, TN3. 2010-2011 Member, RCMI 2010 Symposium abstract and oral presentations selectioncommittees. Meharry Medical College, Nashville, TN.4. September 2010-2011: Member, Internal Advisory Committee Research Centers inMinority Institution (RCMI) program Meharry Medical College, Nashville, TN5. 2005-2008: Medical Students Course Committee, UTMB, Galveston Member, Pathobiology and Host Defense Course Committee Member, Microbiology and Immunology subcommittee of Pathobiology and Host Defense course committee6. 2004-2005 Scientific Grant Review Committee, UTMB, Galveston McLaughlin Postdoctoral Fellowship Funds Institute for Human Infections and Immunity University of Texas Medical Branch Galveston, TXDEPARTMENTAL:1. 2010-2011 Chair, APT committee, Department of Pathology Meharry Medical College, Nashville, TN2. 2005-2008 Director, Safety Committee, Department of Pathology, Clinical Pathology Services, University of Texas Medical branch, Galveston, TX3. 2003-2008 Member, Pathology Quality Management Committee Department of Pathology, Pathology Clinical Services University of Texas Medical Branch, Galveston, TX4. 2007- 2008 Search Committee for Director of Clinical Microbiology Laboratory, Department of Pathology, UTMB, Galveston5. 2007-2008 Member, Laboratory Automation Committee Department of Pathology, Clinical Pathology Services University of Texas Medical Branch, Galveston, TX6. 2008 Member, Educational Internal Review Committee Department of Pathology University of Texas Medical Branch, Galveston, TX7. 2006, 2007 Director of Medical Student Elective Program in Clinical Microbiology,University of Texas Medical Branch, Galveston, TX8. 2005 Member, Faculty Compensation Committee Department of Pathology University of Texas Medical Branch, Galveston, TX
APPOINTMENTS and POSITIONS ACADEMIC:1. 2003-2004: Dept. of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX as Instructor.2. 2004-2008: Dept. of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX as Assistant ProfessorMarch2008-August2008: Dept. of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX as Associate Professor3. 2002-2006: Laboratory Medicine, Division of Clinical Microbiology, Dept. of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX as Assistant Director4. 2006-2008: Laboratory Medicine, Division of Clinical Microbiology, Dept. of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX as Associate Director5. 2005-2007: Clinical Immunology, Serology and Virology Sections, Division of Clinical Microbiology, Dept. of Pathology, University of Texas Medical Branch (UTMB),Galveston, TX as Section Director6. 2007-2008: Bacteriology and Parasitology Sections, Division of Clinical Microbiology, Dept. of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX7. 2003-2008: Sealy Center for Vaccine Development & Center for Biodefense and Emerging Infectious Disease University of Texas Medical Branch, Galveston, TX as Member8. 2008-2011: Department of Pathology, and Department of Microbiology and Immunology, Meharry Medical College, Nashville, TN as Associate Professor9. 2008-2010: Vanderbilt Institute of Clinical &Translational Research, Vanderbilt-Meharry Alliance, Nashville, TN as Director, Oral Pathogen Core10. 2010-2011: Meharry Clinical and Translational Research Center. Meharry Medical College, Nashville, TN as Director, Female Tissue Acquisition Core11. 2008-2011: Center for Women’s Heath Research, Meharry Medical College, Nashville, TN as Member12. 2011 – present: Department of Pathology; University of Pittsburgh; Pittsburgh PA as Visiting Associate Professor of Pathology13. 2011-Present : Magee Women Hospital Clinical Microbiology and Immunology Lab University of Pittsburgh Medical Center as Medical DirectorCERTIFICATION and LICENSURE2008-present: American Board of Medical Microbiology (ABMM)2008-2011: Specialist in Microbiology (SM), Board of Registry, American Society forClinical Pathology (SM, ASCP)2010-present: American Board of Medical Laboratory Immunology (ABMLI)MEDICAL or OTHER PROFESSIONAL LICENSURE1988-present: Permanent Medical License, Ministry of Health, Egypt.MEMBERSHIPS in PROFESSIONAL and SCIENTIFIC SOCIETIES:1996-2000, 2004-2006 , 2008-present: Association of Immunologists (AAI)2007, 2008: Association of Medical laboratory Immunologists (AMLI)2007-present: American Society for Rickettsiology (ASR)2000-present: American Society of Microbiology (ASM), Division C.2001-2004: American Society of Tropical Medicine and Hygiene 1997-2001:Canadian Society of Immunology (CSI)1990-1991: Nordic Molecular Biology Association (NOMBA)1990-1992: Turku Microbiological Society, Turku, FinlandHONORS/AWARDS:1. 2012-2013: Chair-Elect for Division “V” (Clinical and Diagnostic Immunology) of the American Society of Microbiology (ASM).2. 2011: Member, the American Board of Medical laboratory ImmunologyExam Validation committee.3. 2011: Editor, for the American Society of Microbiology, Clinical Microbiology, Portal’s Questions & Answers Committee4. 2011: Invited Speaker, 6th international conferences on Rickettsia and Rickettsial Diseases5. 2010: Invited Speaker, Institute of Medicine, national Academy of Science: Workshop on: Critical Needs and Gaps in Understanding Prevention, Amelioration, and Resolution of Lyme and Other Tick-Borne Diseases: The Short-Term and Long-Term Outcomes6. 2009: Editorial selection of our paper entitled “Persistent infection contributes to Heterologous protective immunity against fatal ehrlichiosis” for the SPOTLIGHT section in Infection and Immunity.7. 2006: Excellence in Teaching Award, Experimental Pathology Graduate program, University of Texas Graduate School of Biomedical Sciences8. 2006: Nominated for the 2006 Graduate Student Organization (GSO) Teacher Student Advocacy Award.9.2002: First Place in postdoctoral fellow award for mechanistic and basic research, Department of Pathology annual Research Day, University of Texas Medical Branch, Galveston, Texas, USA.10.1998: College of Medicine First Prize, Best Poster Award, Annual Research Day, University of Saskatchewan, Saskatoon, Sask., Canada.11. 1993-1995: University of Toronto Open Research Fellowship, University of Toronto, Toronto, Canada.12. 1996-2001: College of Medicine Graduate Scholarships, University of Saskatchewan, Saskatoon, Sask, Canada.
Clinical Research Interest,Basic Research Interest,Bacteriology and Parasitology
1. Power, C. A., C. L. Grand, N. Ismail, N. C. Peters, D. P. Yurkowski, and P. A. Bretscher. A valid ELISPOT assay for enumeration of ex vivo, antigen-specific IFN-gamma producing cells. J. Immunol. Methods. 227:99-107, 1999.2. Ismail N., and P. A. Bretscher. The Th1/Th2 nature of concurrent immune responses to unrelated antigens can be independently determined. The Journal of Immunology.163: 4842-50, 1999.3. Bretscher, P. A., N. Ismail, J. N. Menon, C. A. Power, J. Uzonna, and G. Wei. Vaccination against and treatment of chronic diseases caused by intracellular pathogens: a perspective from studies in basic immunology, immunity in tuberculosis, and leishmaniasis and AIDS. Cellular and Molecular Life Science 58:1879-1896, 2001.4. Ismail, N., and B. Reisner. Update on Respiratory Syncytial virus. Clinical Microbiology Newsletter 23: 91-97, 2001.5. Bretscher, P. A., N. Ismail, N. C. Peters, and J. Uzonna. Cell-to-cell interactions and signaling within the immune system: Towards integrating mechanisms and physiology. New Foundation of Biology; Berczi I., and Gorezynski, R. M. Elsevier Science B.V, 2001.6. Ismail N., and P. A. Bretscher. More antigen-dependent CD4+ T cell/ CD4+ T cell interactions are required for the primary generation of Th2 than Th1 cells. European Journal of Immunology 31:1765-71, 2002. 7. Ismail, N., Juan P. Olano, Hui-Min Feng, and David H. Walker. Current status of immune mechanisms of killing of intracellular pathogens. FEMS Microbiology Letters 207:111-120, 2002.8. Ismail, N., G. E. Fish, and M. B Smith. Laboratory evaluation of a fully-automated chemiluminescence immunoassay for rapid detection of Hepatitis B surface antigen (HBsAg), antibodies to HBsAg and antibodies to Hepatitis C virus, Journal of Clinical Microbiology 42:610-617, 2004.9. Walker, D. H., N. Ismail, J. P. Olano, J. W. McBride, X. J. Yu, and H-M, Feng. Ehrlichia chaffeenesis: A prevalent, life threatening, emerging pathogen. Transactions of the American Clinical and Climatological Association 115: 375-384, 2004.10. Ismail, N., L. Soong, J. W. McBride, G. Valbuena, J. P. Olano, H-M, Feng, and D.H. Walker. Overproduction of TNF alpha by CD8+ type-1 cells and down regulation of IFN-gamma ?production by CD4+ Th1 cells contribute to toxic shock like syndrome in an animal model of fatal monocytotropic ehrlichiosis. The Journal of Immunology 172: 1786-800, 2004.11. Ismail, N., B. Anthony, H. Briscoe, and P. Bretscher. Increasing the foreignness of an antigen, by coupling a second and foreign antigen to it, increases the Th2 component of the immune response to the first antigen. Immunology 115:34-41, 2005.12. Mattner, J., K. L. DeBord, N. Ismail, D. Zhou, C. Cantu III, P. S.Mezard, V. Wang, K. Hoebe, O. Schneewind, D. H. Walker, B. Beutler, L.Teyton, P. B. Savage, A. Bendelac. Both exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434:525-9, 2005.13. Ismail, N., and D. H. Walker. Balancing protective immunity and immunopathology: A Unifying model of monocytotropic ehrlichiosis. Annals of the New York Academy of Science 1063:420-4, 2005.14. Sousa, R. D., N. Ismail, S. D. Nobrega, P. Costa, T. Abreu, A. Franca, M. Amaro, P. Proenca, P. Brito, J. Pocas, T. Ramos, G. Cristina, G. Pombo, L. Vitorino, J. Torgal, F. Bacellar, and D. H. Walker. The presence of Eschars in Portuguese patients infected with Israeli tick typhus strain of Rickettsia conorii. Annals of the New York Acad. of Science 1063:197-202, 2005. 15. Crocquet-Valdes, P.A., J. M. Mcbride, H-M Feng, N. Ismail, A. M. Small, X-J Yu and D. H. Walker. Analysis of ehrlichial P28 gene expression in a murine model of persistent infection. Annals of the New York Academy of Science 1063:420-4, 2005. 16. Walker, D. H., N. Ismail, J. P. Olano, G. Valbuena, and J. W. McBride. Pathogenesis, immunity, pathology, and pathophysiology in rickettsial diseases” Rickettsial Diseases: Old and New, Raoult and Parola, Marcel Dekker Inc, 2006.17. Ismail, N., H. L. Stevenson, and D. H. Walker. The Role of TNF-alpha ?and IL-10 ?in the pathogenesis of severe murine monocytotropic ehrlichiosis: Increased resistance of TNF receptor p55- and p75-deficient mice to fatal ehrlichial infection. Infection and Immunity 74: 1846-56, 2006.18. Stevenson, S. L., Z. Peerwani, J. M. Jordan, H. Q. Wang, D. H. Walker, and N. Ismail. An intradermal environment promotes a protective type-1 response against monocytotropic Ehrlichia. Infection and Immunity 74:4856-64, 2006.19. Stevenson, H. L., N. Ismail and D. H. Walker. Ehrlichiae and ehrlichiosis: Pathogenesis and vector biology. National Institute of Allergy and Infectious Disease: Progress in Research, 2006. 20. Essam, A., S. A., Salama, N. Ismail, and A. Al-Hendy. Towards gene therapy of endometriosis: Adenovirus-mediated delivery of dominant negative estrogen receptor gene inhibits cell proliferation, reduces cytokine production, and induces apoptosis of endometriotic cells. Fertility and Sterility 88:462-7, 2007.21. LaSala, P. R., C. Sanders, K. K. Bufton, N. Ismail, and M. B. Smith. Prospective comparison of R-mix™ shell vial system with direct antigen tests and conventional cell culture for respiratory virus detection. Journal of Clinical Virology 38:210-6, 2007. 22. Fang, R., N. Ismail, L.Soong, V. L. Popov, T. Whitworth, D. H. Bouyer, and D. H. Walker. Differential interaction of dendritic cells with Rickettsia: impact on host susceptibilities to murine spotted fever rickettsiosis, Infection and Immunity 75:3112-23, 2007.23. Ismail, N., Stevenson, H. L., E. C. Crossley, and D. H. Walker. The relative importance of T cell subsets in immunity and immunopathology of monocytotropic ehrlichiosis: A novel effector mechanism involved in Ehrlichia-induced immunopathology in murine ehrlichiosis. Infection and Immunity 75:4608-20, 2007. 24. Sousa, R. D., N. Ismail?, S. D. Nobrega, A. Franca, M. Amaro, M. Anes, J.Pocas, R. Coelho, J. Torgal, F. Bacellar, and D. H. Walker. Intralesional IFN-γ, TNF-α, IL-10, iNOS, indoleamine-2, 3-dioxygenase, and RANTES are major immune effectors in Mediterranean spotted fever rickettsiosis. ?First & second Authors contributed equally, Journal of Infectious Diseases 196:770-81, 2007. 25. Walker, D. H., N. Ismail, and X-J Yu. Vaccines against rickettsial infections, In Vaccines against biothreat and Emerging Infectious Diseases”, Elsevier, 2007. 26. Stevenson, H. L., D. H. Walker, and N. Ismail: Regulatory role of CD1d-restricted NKT cells in the induction of toxic shock-like syndrome in an animal model of fatal ehrlichiosis. Infection and Immunity, 76:1434-44, 2008. 27. Thirumalapura, R. N., D. H. Walker, and N. Ismail: Protective heterologous immunity against fatal ehrlichiosis and lack of protection following homologous challenge. Infection and Immunity, 76:1920-30, 2008. 28. Walker, D. H., and N. Ismail: Rickettsiosis: Emerging and re-emerging endothelial infection and early disease events. Nature Reviews Microbiology, 6:375-86, 2008. 29. Sousa, R. D., A. Franco, S. Doria, M. Amaro, T. Abreu, J. Pocas, P. Proenca, R. Coelho, J. Vaz, J. Torgal, F. Bacellar, N. Ismail, D. H. Walker. Host and microbial risk factors and pathophysiology of fatal Rickettsia conorii infection in Portuguese patients. Journal of Infectious Disease, 198:576-85, 2008. 30. Rapose, A., S. D. Lick, and N. Ismail. Listeria grayi in a heart transplant. Transplant infectious disease, 10:434-6, 2008. 31. Thomas, S., N. R. Thirumalapura, E. C. Crossley, N. Ismail, and D. H. Walker. Antigenic protein modifications in Ehrlichia, Parasite Immunology, 31:296-303, 2009. 32. Duane Hamilton, N. Ismail, D. Kroeger, C. Rudulier, and P. Bretscher. Macroimmunology and immunotherapy of cancer. Immunotherapy, 31:296-303, 2009.33. Fang, R., N. Ismail, and D. H. Walker. CD4+CD25+ Foxp3-CTLA-4+ T regulatory cells are the major source of IFN-gamma ?and IL-10 in acute fatal rickettsial infection. Infection and Immunity, 77:3838-49, 2009. 34. Thirumalapura, N. R., E.C. Crossley, D. H. Walker, and N. Ismail. Persistent infection contributes to heterologous protective immunity against fatal ehrlichiosis. Infection and Immunity, 77:5582-9, 2009.35. Stevenson, H.L., D. M. Estes, R. N. Thirumalapura, D. H. Walker, and N. Ismail. Natural Killer Cells Promote Tissue Injury and Systemic Inflammatory Responses during Fatal Ehrlichia-Induced Toxic Shock-like Syndrome. American Journal of Pathology, 177: 766-776, 2010. 36. Ismail, H., M. Soliman, and N. Ismail. Occult Hepatitis B Virus Infection in Hemodialysis Egyptian Patients with or without Hepatitis C virus Infection. Open Access Pathology and Laboratory Medicine International, 2:113-120, 2010.37. Ghose, P., A. Q. Ali, R. Fang, D. Forbes, B. Ballard, and N. Ismail. The interaction between IL-18 and IL-18R limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria. J. Immunol. 187:1333-46, 2011.38. Ghose, P., and N. Ismail The Interaction between IL-18 and IL-18 Receptor Limits the Magnitude of Protective Immunity and Enhances Pathogenic Responses following Infection with Intracellular Bacteria. Protein Disease case report – Highlighted by Target Intelligence service, 2011.39.Valdes, P., N. R. Thirumalapura, N. Ismail, X-j, Yu, H. L. Stevenson, C. Pietzche, S. Thomas and D. H. Walker. Immunization with Ehrlichia outer membrane P28 proteins confers protection in a mouse model of ehrlichiosis. Clinical Vaccine Immunology. 18:2018-25, 2011.40. Fang, R., N. Ismail, and D. H. Walker. NK cells contribute greatly to host innate resistance to murine spotted fever rickettsiosis. Favorable Review, Am. J. Pathology, 2011.41. Ismail, N., D. H. Walker, P. Ghose, and Yi-W. Tang. Immune Mediators of Protective and Pathogenic Immune Responses in Patients with Mild and Fatal Human Monocytotropic Ehrlichiosis. Favorable review, BMC Immunology, 2012.
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