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WMC Cellular Biology Faculty
 
WMC Cellular Biology Faculty
 

Prof. Venkateswarlu Kanamarlapudi

Professor of Molecular Cell Biology and Pharmacology
Swansea University
ILS1, COLLEGE OF MEDICINE
United Kingdom
SA2 8PP

 
 

Brief Biography:

I obtained BSc (Biology & Chemistry; 1983-‘86) from Nagarjuna University, MSc (Biochemistry; 1986-’88) from the University of Hyderabad and MTech (Biotechnology; 1988-90) from IIT-Kharagpur.

After working for 3 years as a research scientist at Astra Research Centre India (now AstraZenca India) in Bangalore on anti-microbial drugs, I was awarded a Commonwealth scholarship to pursue PhD at the University of Sheffield. My PhD training (1993-’96) with Professor Steven Kelly at the University of Sheffield (now Professor at Swansea University) was directed towards understanding azole antifungal drugs mode of action and the mechanisms of azole drug resistance.

After obtaining my PhD degree in 1996, I worked as a postdoctoral researcher for 3 years in Professor Peter Cullen’s laboratory at the University of Bristol on the involvement of lipid second messenger PIP3 in regulation of ADP-ribosylation factor (ARF) small GTPase cell signalling.

I was awarded a prestigious 5 year BBSRC David Phillips Research Fellowship (DPRF) in 1999 to continue my studies (as an independent investigator) on the involvement of PIP3 in regulation of ARF cell signalling in Department of Pharmacology at the University of Bristol. I was appointed as a lecturer in 2004 in the department of Pharmacology at the University of Bristol.

In 2007 I moved to Swansea University to take up Research Reader in Molecular Cellular Biology and Pharmacology position in College of Medicine. I was promoted to a Personal Chair in 2009.

 

Academic positions:

1990 - 1993 Research Scientist, AstraZeneca India, Bangalore, India.

1996 - 1999 Postdoctoral Researcher, Dept. of Biochemistry, Bristol University, UK

1999 - 2004 BBSRC David Phillips Research Fellow, Dept. of Pharmacology, Bristol University, UK

2004 - 2007 Lecturer, Department of Pharmacology, Bristol University, UK

2007 - 2009 Reader in Molecular Cell Biology and Pharmacology, College of Medicine, Swansea University, UK

2009 - present  Professor of Molecular Cell Biology and Pharmacology, College of Medicine, Swansea University, UK

 

Research interests:

We have been concentrating our efforts for more than 12 years in studying ADP-ribosylation factor (ARF)6 small GTPase and PI 3-kinase mediated cell signalling in health and disease. We have developed novel biochemical and fluorescence based assays to analyse in vivo ARF6 activation and phosphoinositide (PI) binding. We have also isolated ARF6 regulators and their interacting proteins to study spatial assembly of multi-protein complexes. Although it is now established that ARF6 and PI 3-kinase signalling pathways play vital roles in cellular functions, the physiological significance of these signalling pathways has not yet been explored. Therefore, we are currently concentrating our efforts in studying the individual and interplay between ARF6 small GTPase and PI signalling pathways particularly in hematopoietic cells, stem cell differentiation and cancer spreading using a wide variety of molecular, cell biological, biochemical and pharmacological approaches.

 

Any other information:

We published the findings of our work as several papers in highly reputed international journals. Moreover, we obtained research funding from BBSRC, MRC, BHF etc to continue the work in this field. My expertise in Molecular Cellular Biology, particularly in the fields of small GTPase and PI signalling, is acknowledged by regular service as a reviewer for research funding bodies and international journals.

Recent Peer-Reviewed Publications

  1. Kanamarlapudi, V., S. E. Owens, K. Saha, R. J. Pope and S. J.Mundell.  (2012)  ARF6-dependent regulation of P2Y receptor traffic and function in human platelets.  PLoS ONE 7(8):e43532.
  2. Eva, R., S. Crisp, J. Marland, J. Norman, V. Kanamarlapudi, C. fFrench-Constant, and J. Fawcett.  (2012)  ARF6 Directs Axon Transport and Traffic of Integrins, and Regulates Axon Growth in adult DRG neurons.  J. Neuro. Sci. 32:10352-10364.
  3. Kanamarlapudi, V., S. E. Owens, J. Lartey and A. Lopez Bernal.  (2012)  ARF6 expression and activities are reduced in myometrium in complicated pregnancies.  PLoS ONE 7(5): e37954. doi:10.1371/journal.pone.0037954
  4. Kanamarlapudi, V., A. Thompson, E. Kelly and A. Lopez Bernal.  (2012)  ARF6 activated by the LHCG receptor through the cytohesin family of guanine nucleotide exchange factors mediates the receptor internalisation and signalling.  J. Biol. Chem. 287:20443-20455.
  5. Benjamin J. Gosney and V. Kanamarlapudi. ADAP2. UCSD-Nature Molecule Pages (2011). (doi:10.1038/mp.a000615.01).
  6. Aiysha Thompson and V. Kanamarlapudi. Arf-like protein 8A. UCSD-Nature Molecule Pages (2011). (doi:10.1038/mp.a003891.01).
  7. Jonathon C. Davies and V. Kanamarlapudi. SMAP2. UCSD-Nature Molecule Pages (2011). (in press).
  8. Aiysha Thompson and V. Kanamarlapudi. Arf-like protein 8B. UCSD-Nature Molecule Pages (2011). (doi:10.1038/mp.a003892.01).
  9. V. Kanamarlapudi and Lisa-Marie Wilson. ADP-ribosylation factor domain protein 1. UCSD-Nature Molecule Pages (2011). (doi:10.1038/mp.a003292.01).
  10. Jonathon C. Davies and V. Kanamarlapudi. SMAP1. UCSD-Nature Molecule Pages (2010). (doi:10.1038/mp.a003290.01).
  11. Sian-Eleri Owens and V. Kanamarlapudi. AGAP1. UCSD-Nature Molecule Pages (2010). (doi:10.1038/mp.a000225.01).
  12. Sian-Eleri Owens and V. Kanamarlapudi. ARAP3. UCSD-Nature Molecule Pages (2010). (doi:10.1038/mp.a003288.01).
  13. Benjamin J. Gosney and V. Kanamarlapudi. ACAP1. UCSD-Nature Molecule Pages (2010). (doi:10.1038/mp.a000164.01).
  14. Benjamin J. Gosney and V. Kanamarlapudi. ADAP1. UCSD-Nature Molecule Pages (2010). (doi:10.1038/mp.a000614.01).
  15. Kalscheuer, V. M., L. Musante, C. Fang, K. Hoffmann, C. Fuchs, E. Carta, E. Deas, K. Venkateswarlu, et al.  (2009)  A Balanced Chromosomal Translocation Disrupting ARHGEF9 Is Associated With Epilepsy, Anxiety, Aggression, and Mental Retardation.  Human Mutat. 30: 61-68.
  16. Steward, R., L. Song, S. M. Carter, C. Sigalas, N. R.. Zaccai, V. Kanamarlapudi, M. B. Bhat, H. Takeshima and R. Sitsapesan (2008)  Single-Channel Characterization of the Rabbit Recombinant RyR2 Reveals a Novel Inactivation Property of Physiological Concentrations of ATP.  J. Memb. Biol. 222:65-77.
  17. Bouschet, T., S. Martin, K. Venkateswarlu, S. Mundell and J. M. Henley.  (2007)  The calcium sensing receptor remodels cell shape via β-arrestin-ARNO-ARF6-ELMO protein network.  J. Cell Sci. 120:2489-2497.
  18. Venkateswarlu, K., K. G. Brandom and H. Yun.  (2007)  PI 3-kinase-dependent membrane recruitment of centaurin-a2 is essential for its effect on ADP-ribosylation factor 6-mediated actin cytoskeleton reorganisation.  J. Cell Sci. 120:792-801.
  19. Kanumilli, S., E. W. Tringham, C. E. Payne, J. R. B. Dupere, K. Venkateswarlu and M. M. Usowicz.  (2006)  Alternative splicing generates a smaller assortment of CaV2.1 transcripts in cerebellar Purkinje cells than in the cerebellum.  Physiol. Genomics. 24:86-96.
  20. Gunn-Moore, F. J., G. I. Welsh, L. R. Herron, F. Brannigan, K. Venkateswarlu, S. Gillespie, M. Brandwein-Gensler, r. Madan, J. M. Tavare, P. J. Brophy, M. B. Prystowsky and Guild, S.  (2005)  A novel 4.1 ezrin radixin moesin (FERM) containing protein, ‘Willin’.  FEBS Letts. 579: 5089-5094.
  21. Venkateswarlu, K., T. Hanada and H. Chishti (2005)  Centaurin-a1 interacts directly with motor protein KIF13B.  J. Cell Sci., 118: 2471-2484.
  22. Lawrence, J. L., S. J. Mundell, H. Yun, E. Kelly and K. Venkateswarlu (2005).  Centaurin-a1, an ARF6 GTPase activating protein, inhibits internalization of b2-Adrenoceptor.  Mol. Pharm. 67: 1821-1827.
  23. Venkateswarlu, K., K. G. Brandom and J. L. Lawrence.  (2004)  Centaurin-a1 is an in vivo PIP3-dependent GAP for ARF6 that is involved in actin cytoskeleton organization.  J. Biol. Chem., 279: 6205-6208.
  24. Venkateswarlu, K. (2003)  IPCEF1 interacts with and regulates cytohesin 2 activity.  J. Biol. Chem. 278: 43460-43469.
  25. Kanumilli, S., N. J. Toms, K. Venkateswarlu, H. Mellor and P. J. Roberts (2002).  Functional coupling of rat mGluR1a receptor to phospholipase D in CHO cells: Involvement of extracellular Ca2+, PKC, tyrosine kinase and RhoA.  Neuropharm., 42:1-8.
  26. Bobe,R., J. Wilde, P. Maschberger, K. Venkateswarlu, P. J. Cullen, W. Siess and S. P Watson.  (2001)  PI 3-kinase dependent translocation of phospholipase Cg2 in mouse megakaryocytes is independent of Btk translocation.  Blood, 97: 678-684.
  27. Dubios, T., P. Kerai, E. Zemlickova, S. Howell, T. R. Jackson, K. Venkateswarlu, A. B. Theibert, L.Larose, P. J. Roach and A. Aitken.  (2001)  Casein kinase I associates with members of the centaurin- family of phosphatidylinositol-(3,4,5)-trisphosphate-binding proteins.  J. Biol. Chem., 276: 18757-18764.
  28. Lamb, D.C., A. G. S. Warrilow, K. Venkateswarlu, D. E. Kelly and S. L. Kelly.  (2001)  Activities and kinetic mechanisms of native and soluble NADPH-cytochrome P450 reductase.  Biochem. Biophys. Res. Commun., 286: 48-54.
  29. Lamb, D. C., N. N. Kaderbhai, K. Venkateswarlu, D. E. Kelly, S. Kelly and M. A. Kaderbhai.  (2001)  Human sterol 14a-demethylase activity is enhanced by the membrane-bound state of cytochrome b5.  Arch. Biochem. Biophys., 395: 78-84.
  30. Venkateswarlu, K. and P. C. Cullen.  (2000)  Signalling via ARF6 lies downstream of PI 3-kinase.  Biochem. J., 345: 719-724.
 

What I think of the idea behind WebmedCentral:

I strongly support the Webmedcentral model of publishing (open access, post publication peer review and transparency in scientific communications). This is because it will allow access of good scientific information by researchers in whole world without subscription.

 

Home Page:

http://www.swan.ac.uk/ils/research/biomed/immunityandallergy/cellsignalling/