Open Access Biomedical Publisher Using Post Publication Peer Review
Professor of Molecular Cell Biology and Pharmacology Swansea University
ILS1, COLLEGE OF MEDICINE United Kingdom SA2 8PP
I obtained BSc (Biology & Chemistry; 1983-‘86) from Nagarjuna University, MSc (Biochemistry; 1986-’88) from the University of Hyderabad and MTech (Biotechnology; 1988-90) from IIT-Kharagpur.
After working for 3 years as a research scientist at Astra Research Centre India (now AstraZenca India) in Bangalore on anti-microbial drugs, I was awarded a Commonwealth scholarship to pursue PhD at the University of Sheffield. My PhD training (1993-’96) with Professor Steven Kelly at the University of Sheffield (now Professor at Swansea University) was directed towards understanding azole antifungal drugs mode of action and the mechanisms of azole drug resistance.
After obtaining my PhD degree in 1996, I worked as a postdoctoral researcher for 3 years in Professor Peter Cullen’s laboratory at the University of Bristol on the involvement of lipid second messenger PIP3 in regulation of ADP-ribosylation factor (ARF) small GTPase cell signalling.
I was awarded a prestigious 5 year BBSRC David Phillips Research Fellowship (DPRF) in 1999 to continue my studies (as an independent investigator) on the involvement of PIP3 in regulation of ARF cell signalling in Department of Pharmacology at the University of Bristol. I was appointed as a lecturer in 2004 in the department of Pharmacology at the University of Bristol.
In 2007 I moved to Swansea University to take up Research Reader in Molecular Cellular Biology and Pharmacology position in College of Medicine. I was promoted to a Personal Chair in 2009.
1990 - 1993 Research Scientist, AstraZeneca India, Bangalore, India.
1996 - 1999 Postdoctoral Researcher, Dept. of Biochemistry, Bristol University, UK
1999 - 2004 BBSRC David Phillips Research Fellow, Dept. of Pharmacology, Bristol University, UK
2004 - 2007 Lecturer, Department of Pharmacology, Bristol University, UK
2007 - 2009 Reader in Molecular Cell Biology and Pharmacology, College of Medicine, Swansea University, UK
2009 - present Professor of Molecular Cell Biology and Pharmacology, College of Medicine, Swansea University, UK
We have been concentrating our efforts for more than 12 years in studying ADP-ribosylation factor (ARF)6 small GTPase and PI 3-kinase mediated cell signalling in health and disease. We have developed novel biochemical and fluorescence based assays to analyse in vivo ARF6 activation and phosphoinositide (PI) binding. We have also isolated ARF6 regulators and their interacting proteins to study spatial assembly of multi-protein complexes. Although it is now established that ARF6 and PI 3-kinase signalling pathways play vital roles in cellular functions, the physiological significance of these signalling pathways has not yet been explored. Therefore, we are currently concentrating our efforts in studying the individual and interplay between ARF6 small GTPase and PI signalling pathways particularly in hematopoietic cells, stem cell differentiation and cancer spreading using a wide variety of molecular, cell biological, biochemical and pharmacological approaches.
We published the findings of our work as several papers in highly reputed international journals. Moreover, we obtained research funding from BBSRC, MRC, BHF etc to continue the work in this field. My expertise in Molecular Cellular Biology, particularly in the fields of small GTPase and PI signalling, is acknowledged by regular service as a reviewer for research funding bodies and international journals.
Recent Peer-Reviewed Publications
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