Webmedcentral - Wound healing ArticlesThe Wound healing articles published by Webmedcentral
http://www.webmedcentral.com
2024-03-29T05:49:00+01:00webmedcentral logo
http://www.webmedcentral.com/
http://www.webmedcentral.com/images/Header_Logo.giftext/html2010-12-13T14:58:57+01:00http://www.webmedcentral.com/Mr. Tariq SainuddinFormulation & Pharmacological Evaluation Of Herbal Gel Of Pothos Scandens Linn
http://www.webmedcentral.com/article_view/1344
Over the past decade, herbal medicine has become an item of global importance both medicinal and economical. Although usage of these herbal medicines has increased, their quality, safety and efficiency are serious concerns in industrialized and developing countries. Thus accurate scientific assessment has become a prerequisite for acceptance of herbal health claims. Pothos scandens Linn. (Family: Araceae) have a great medicinal value for its wound and burn healing properties. The plant is seen many parts of South India especially in wild areas. Traditionally the plant is used by Ayurvedic physicians of Cheruvathur, Kerala mainly for its burn healing properties. For natural product discovery the conventional approach of extraction, identification and characterization of compounds, test for desired biological activity and finally formulating in a suitable dosage forms. Ayurveda based drug discovery uses “Reverse Pharmacology” in which drug candidates are first identified based on large-scale use in population, and then validated in clinical trials. Experts say this approach can cut time from 12 to 15 years for drug discovery and are economical. By providing scientific information on medicinal plants and converting these medicinal plants into good formulations can influence its productivity, therapeutic efficiency and competitiveness in the field of medicine and pharmacy.text/html2013-01-28T11:03:09+01:00http://www.webmedcentral.com/Dr. Murtaza A CalcuttawalaWound Healing Made Unlimited
http://www.webmedcentral.com/article_view/3973
Background: Ten patients of lower limb ulcer admitted between October 2011 and April 2012 were treated and studiedMaterial and Methods: All patients were diagnosed on the basis of clinical and radiological findings and after that laser therapy was performed. This was followed by accelerated healing of wound and in some cases by covering the wound by split thickness skin graft.Results: All patients were male, maximum incidence was noted in the age group of 34 to 84 years.Conclusion: The laser therapy resulted in enhanced healing as measured by wound contraction.text/html2013-02-01T14:55:11+01:00http://www.webmedcentral.com/Dr. Nilkamal KumarPlatelet Derived Growth Factor in Healing of Large Diabetic Foot Ulcers in Indian Clinical Set-up: A Protocol-based Approach
http://www.webmedcentral.com/article_view/3985
AIM: To determine the effectiveness of topical recombinant human platelet derived growth factor (rh-PDGF- 100ug/ml) based dressing over conventional dressing for large chronic neuropathic diabetic foot ulcers.
Study Design: A prospective cohort study.
Methods: Diabetic patients with large chronic neuropathic foot ulcers were divided into conventional dressing group & rh-PDGF based dressing group. Once a day, topical rh-PDGF gel was applied in conjunction with standard wound care. The intervention was stopped on complete wound healing or at 10 weeks, whichever occurred first.
Results: Nineteen patients received PDGF-based dressings and 23 patients received conventional dressings. Data analysis showed that complete healing was significantly higher in the growth factor group (p value: <0.05, Fisher Exact Test). In addition, median reduction in ulcer surface area was also significantly high in rh-PDGF group at 4 & 6 weeks intervals (p value: <0.001 and <0.014 respectively).
Conclusion: Findings indicate that rh-PDGF based dressing is more effective than standard therapy. This effect is more pronounced in large severe wounds and wounds in immunocompromised patients. Unfortunately, large wounds and wounds in immunocompromised patients have not been evaluated in clinical trials of new agent interventions. Therefore, we encourage the inclusion of these patients in future trials.