My research interest is to understand the mechanism(s) underlying neuronal death in Alzheimer's and other neurodegenerative diseases. The major focus of my current work is the the mechanisms underlying mitochondrial dysfunction in Alzheimer's (AD) and Parkinson's disease (PD). Mitochondrial dysfunction has long been recognized as prominent features of both AD and PD. However, the mechanisms responsible for mitochondrial dysfunction,and its role in these diseases were not clear. Recent studies in the field of basic research on mitochondria reveal that they are dynamic organelles that undergo continual fission and fusion events which serve crucial physiological function. Riding on this recent tide of better characterization of mitochondrial dynamics, studies are underway to investigate the role of mitochondria dynamics in the pathogesis of AD and PD. Specific Questions include: Whether and how disease-assocaited genetic factors affects mitochondrial dynamics and function; whether and how alterations in mitochondrial dynamics cause disease-relevant changes; Can we target mitochondrial dynamics for therapeutic development?