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Epigenetically active drugs target metabolic gene-regulation in leukemic cells
Abstract: Background: Up-regulation of energy metabolism is a key feature of proliferating cells from cancers and leukemias. Thus, targeting of metabolic pathways represents a therapeutic challenge involving both dietary and drug-mediated strategies. The aim of this study was to evaluate the impact of the DNA-methyltransferase-i..
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Novel Agents In CML Therapy: Tyrosine Kinase Inhibitors and Beyond
Abstract: Treatment of Chronic myeloid leukemia represents one of cancer’s success stories. Deregulated tyrosine kinase activity of the BCR-ABL fusion protein has been established as the causative molecular event in CML. The drug Imatinib has revolutionized the treatment of CML and has become the gold standard of care in CML f..
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Secondary Non Hodgkinian Lymphoma in a Patient Treated for Hodgkin Disease: A Case Report with Comprehensive Literature Review
Abstract: The introduction of the intensive radiotherapy and chemotherapy has transformed the prognosis of Hodgkin disease and the long-term complications of the therapy became more frequent,?furthermore the carcinogenic effect of the used therapeutical agents leading to a high incidence of second malignancies was clearly demons..
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Long-term Supression Of Bone Marrow With Prolonged Pancytopenia After Ibritumomab Tiuxetan In Jehovah's Witness Patient With Relapsed Follicular Non-hodgkin's Lymphoma
Abstract : A 39-year old female Jehovah’s Witness patient presented with a relapse of B-cell follicular non-Hodgkin’s lymphoma.We had to avoid administration of any blood components as part of the treatment due to the conflict with the patient’s religious beliefs. Instead of administering a high-dose chemotherapy followed b..
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Long-term Supression Of Bone Marrow With Prolonged Pancytopenia After Ibritumomab Tiuxetan In Jehovah's Witness Patient With Relapsed Follicular Non-hodgkin's Lymphoma
Abstract : A 39-year old female Jehovah’s Witness patient presented with a relapse of B-cell follicular non-Hodgkin’s lymphoma.We had to avoid administration of any blood components as part of the treatment due to the conflict with the patient’s religious beliefs. Instead of administering a high-dose chemotherapy followed b..
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Secondary Non Hodgkinian Lymphoma in a Patient Treated for Hodgkin Disease: A Case Report with Comprehensive Literature Review
Abstract: The introduction of the intensive radiotherapy and chemotherapy has transformed the prognosis of Hodgkin disease and the long-term complications of the therapy became more frequent,?furthermore the carcinogenic effect of the used therapeutical agents leading to a high incidence of second malignancies was clearly demons..
-
Novel Agents In CML Therapy: Tyrosine Kinase Inhibitors and Beyond
Abstract: Treatment of Chronic myeloid leukemia represents one of cancer’s success stories. Deregulated tyrosine kinase activity of the BCR-ABL fusion protein has been established as the causative molecular event in CML. The drug Imatinib has revolutionized the treatment of CML and has become the gold standard of care in CML f..
-
Epigenetically active drugs target metabolic gene-regulation in leukemic cells
Abstract: Background: Up-regulation of energy metabolism is a key feature of proliferating cells from cancers and leukemias. Thus, targeting of metabolic pathways represents a therapeutic challenge involving both dietary and drug-mediated strategies. The aim of this study was to evaluate the impact of the DNA-methyltransferase-i..
- View all
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- Novel Agents In CML Therapy: Tyrosine Kinase Inhibitors and Beyond ... on 22nd Oct 2013
- Epigenetically active drugs target metabolic gene-regulation in leukemic cells ... on 07th Sep 2013
- Epigenetically active drugs target metabolic gene-regulation in leukemic cells ... on 04th Sep 2013
- Epigenetically active drugs target metabolic gene-regulation in leukemic cells ... on 07th Aug 2013
- Long-term Supression Of Bone Marrow With Prolonged Pancytopenia After Ibritumoma... on 15th Nov 2011
- Latest CommentsView all
- comment to review fr.. Posted on Long-term Supression Of Bone Marrow Wi...