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Abstract: QBEST, a novel statistical method, can be applied to the problem of estimating the No Observed Adverse Effect Level (NOAEL) of a New Molecular Entity (NME) in order to anticipate a safe starting dose for beginning clinical trials. The NOAEL from QBEST (called the QNOAEL) can be calculated using multiple disparate studi..

Abstract: Objective: This study determined the toxicity and toxicokinetics of polydatin when administered via oral gavage to Sprague Dawley rats daily for 4 weeks. Background: Polydatin continues to be investigated as a potential therapy for a variety of human diseases. Methods: Male and female Crl:CD(SD) rats were assigned to f..

Abstract : Amitraz is the common name for N'-(2,4-dimethylphenyl)-N-[[(2,4-dimethylphenyl) imino] methyl]-N-methylmethanimidamide. Amitraz is a triazapentadiene compound, a member of the amidine chemical family. It is an insecticide and acaricide used to control red spider mites, leaf miners, scale insects, and aphids. On cotton ..

Abstract : Gadolinium based MRI contrast agents are functional and cationic morphometric markers but toxic to cause undefined fibrosis in skin and kidney damage. Magnetic Resonance Microimaging of rat skin and kidney was used first time to identify the physical factors modulating the gadolinium Omniscan® induced fibrosis by prot..

Abstract: The aim of this study was to examine whether the neonatal injection of capsaicin induces DNA ladder formation, as an indicator of apoptosis, in the rat trigeminal ganglion (TG). The DNA extracted from the TGs after treatment with capsaicin (50 mg/kg) at 2 days of age exhibited diffuse DNA fragmentation instead of “la..

Introduction: Cleopatra had been the source of mystery and intrigue throughout her life. It is imperative to remember that Cleopatra was a real human being while studying her life and, most ironically, her death. Her mythical status has been embellished throughout the past two thousand years by the numerous writers, historians, arti..

Abstract : In recent years, heavy metal toxicity related to the use of traditional Chinese and Indian herbal medications has been reported in a number of countries, including Australia. Heavy metals such as lead or mercury may be introduced into herbal medications through contaminated soil or production techniques, or may be deli..

Introduction: The 1892 murder of Andrew and Abby Borden has been immortalized through the generation in rhyme and verse. The savage murders have become part of the fabric of American folklore. Would-be mystery sleuths have expounded numerous theories as to who actually carried out the murders. Most theories have pointed To Andrew’..

Abstract : Detection of ethyl alcohol and its origin in postmortem specimens is essential in terms of medico-legal aspects. It is a complicated process to determine whether alcohol has been taken in the ante-mortem period and/or originates from postmortem endogenous production.In this study, considering sampling sites and storage..

Introduction: BLOODBlood is considered a specialized form of connective tissue, given its origin in the bones and the presence of potential molecular fibers in the form of fibrinogen. Blood is a tissue composed of formed elements suspended in a liquid portion called plasma. Red blood cells (erythrocytes), white blood cells (leucocyt..