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- Triple-Negative Breast Cancer: a brief overview.
Abstract : Background Triple-negative breast cancer (TNBC) is a heterogeneous disease that accounts for 15-20% of all breast cancers. This represents the most challenging molecular subtype of breast cancer. Methods This article will make a comprehensive review of these therapies in the treatment of TNBC and it will give a glimpse..
- Difference in Surgical Outcomes between Open and Closed Approach of Palatal Displaced Maxillary Canines: a systematic review
Abstract : Palatally displaced canines or PDCs are upper permanent canines, are very important teeth that define the aestethics of smile. However, these teeth can be impacted during the long period between gems formation and their eruption. This leave unsightly gaps, cause damage to the surrounding roots (which can be so severe t..
- Comparation between Surgical and Orthodontic Uprighting Procedures for the Management of Impacted Mandibular Second Molars: a systematic review
Abstract : Mandibular second molars are one of the most frequent type of teeth to be impacted, after the third molars and maxillary canines. The prevalence of impacted second molars is low, varying from 0% to 2.3%; and the aetiology of impaction can involve multiple factors: systemic, local, and periodontal factors, as well as a ..
- Correlations between mandibular asymmetries and temporo-mandibular disorders (TMD): literature review.
Introduction: Cranio-facial asymmetries, and in particular those with mandibular involvement, are a topic of great interest in modern literature, both for the different diagnostic frameworks of reference, and for the possible therapeutic approaches that can provide only orthodontics or in combination with maxillofacial surgery. One ..
- Skeletal and dentoalveolar effects in patients with Class II malocclusions using Twin Block appliance A review of literature
Abstract : Functional appliances therapy have been shown to be an effective treatment protocol for growing Class II patients, through a combination of skeletal and dentoalveolar effects. Many literature studies revealed a significant increase in mandibular length and a minimum restriction on the maxillary growth in Class II maloc..
- Evaluation of skeletal and dental changes in Class II patients treated with Frankel appliance.
Abstract : The aim of the present article is to assess the treatment results of Class II, Division 1 patients with mandibular retrusion using the Frankel appliance. Several studies demonstrated that the FR appliance produced no significant changes in the maxillary development and a statistically significant increase in the mandib..
- ORAL FEATURES AND ORTHODONTIC TREATMENTS IN SUBJECTS WITH CLEIDOCRANIAL DISPLASYA: a review
Abstract : The Cleidocranial Dysplasia (CCD), is a rare autosomal dominant disease due to a genetic mutation; it primarily affect skull, clavicles and dentition.Dentists are often the first to encounter patients with CCD, for this reason it is important they have a deep knowledge about the clinical features of this disorder. A re..
- Skeletal and dental effects of Herbst appliance in II class malocclusions: a systematic review
the aim of this review is to evaluate the effectiveness of using Herbst Appliance in II class malocclusions caused by a backward mandibular position. : Skeletal and dental effects of Herbst appliance in II class malocclusion: a systematic review Abstract: the aim of this review is to evaluate the effectiveness of using Herbst Appliance in II class malocclusions caused by a backward mandibular position. Materials and method: for this review scientific articles found..
- GIVE UP ON REMIFENTANIL LABOR ANALGESIA: India-Based Anesthesiologist and America-Based Anesthesiologist Siblings' Dialogue Series
Abstract: Question: Should We Give Up On Remifentanil Labor Analgesia As A Potential Alternative To Labor Epidural Analgesia? Answer: It Depends...
- FUN IS MORE IMPORTANT THAN FOOD: India-Based Anesthesiologist and America-Based Anesthesiologist Siblings' Dialogue Series
Abstract: Question: Why Don’t We Enjoy Our Jobs Which Put Food On Our Tables? Answer: May Be Our Souls Are Searching For Fun Rather Than Food...
- RUSH HOUR DRIVING NUTS: India-Based Anesthesiologist and America-Based Anesthesiologist Siblings' Dialogue Series
Abstract: Question: Why Do Our Rush Hours Drive Us Nuts? Answer: May Be Our Millenniums’ Old Circadian Rhythm Is Fighting A Losing Battle...
- RESPITE CARE FOR OCCUPATIONAL HEALTH OF WORKING PARENTS: India-Based Anesthesiologist and America-Based Anesthesiologist Siblings' Dialogue Series
Abstract: Question: Who Is A Godparent? Who Is A Third Parent? Answer: May Be The Extra One Who Not Only Helps To Rear The Child But Also Provides Respite Care To Child’s Parents...
- ANTICOAGULANT-ANTIPLATELET MEDICATIONS BEYOND NEURAXIAL PROCEDURES: India-Based Anesthesiologist and America-Based Anesthesiologist Siblings' Dialogue Series
Abstract: Question: Are We, As Anesthesiologists, Worried About Anticoagulant-Antiplatelet Only When Performing Neuraxial Procedures? Answer: May NOT Be...
- A model to prevent benign breast diseases (BBD) and/or breast cancers using warm running water and massage (or tap)
Abstract: Abstract Background: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women in the world. Benign breast diseases (BBD), such as breast gland hyperpl..
- Review of the endoscopic and medical management of non-variceal Upper Gastro-intestinal Bleeding
Abstract : Acute Upper Gastro-intestinal bleeding(UGIB), defined as bleeding from a source that is proximal to the ligament of treitz, is a potentially life threatening medical emergency. The underlying pathophysiology of non-variceal upper GI bleeds involve either arterial haemorrhage, such as in mucosal tears or GI ulcers, or v..
- Comparison of Analytical Techniques for Thermal Stability Analysis of Beta-Cyclodextrin for an Ebola Virus Infection Treatment
ABSTRACT: Each New Drug Application filed with the Food and Drug Administration (FDA) must include the analytical procedures to ensure the identity, strength, quality, purity, and potency of a drug substance and drug product. The BSN389 drug product (being developed to treat Ebola virus infections) includes beta cyclodextrin..
- Setting Starting Level for a Trial of a Biofilm-Disrupting Adjuvant
Abstract: Combination therapy is beneficial treatment modality for multiple diseases. Cinnamon oil may be an advantageous agent in a number of combination therapies as cinnamon oil has antibacterial activity. Cinnamon oil has also been shown to be effective against biofilm cultures of Streptococcus mutans and Lactobacillus plant..
- Characterization of BSN175: A Drug to Treat Prader-Willi Syndrome
ABSTRACT: The purpose of this research is to choose the best analytical method for determining stability of BSN175. This research uses an accelerated stability study to compare the decomposed and stable drug using IR and 1H NMR spectroscopy. The Bootstrap Error-adjusted Single-sample Technique (BEST) was used to compare the effe..
- The Core Question Named "Whydunit"
My opinion: I am addicted to reading because I am addicted to exploring. Recently I read three books, not in a particular sequence, which aligned my line of thought to a tee. The first book was The Alienist by Caleb Carr [1], read after religiously watching television series, The Alienist on TNT [2], a cable television network. Th..
- Ask Joint Commission: What Say When Overlay?
Abstract: The prevalence of overlays (overwriting) in electronic medical record (EMR) system has been well established. The literature is abundant in regards to the consequences of overlays for patient safety, the technical costs of cleaning EMR from its overlays, and the essentiality to prevent overlays. However, it is not clea..
- Freedom for Vacation with Telehealth
My opinion: Documentation in recent medical literature about successful exploration of telehealth for distant and poorly accessible geographical regions' patients' primary care's continuity has intrigued us.1 It has made us wonder if this avenue can be explored from primary care physicians' personal perspective wherein telehealth ..
- Do Operating Room Work Environments Associate With Personnel's Contact Lenses' Abandonment? A Questionnaire Study Worth Exploring
Background: Since the time when our department's paper [1] was published about the potential incidence of dry eye problems in relation to operating room environments, the thought process has been in the need for further clinical research investigation. To gauge the potential of our operating room environments possibly affecting th..
- Are We Prescribing More Than 3-Days Worth Opioids' Prescriptions To Our Outpatient Surgical Patients When Discharged On Day Of Surgery? A Quality Improvement Study Worth Exploring
Background: Since the time when Centers for Disease Control and Prevention (CDC) came up with the guidelines [1] to further responsible attitude towards opioid prescriptions in acute pain settings, we have been wondering the status of awareness among opioid prescribers in our institution as well as their responsiveness to the CDC .. - Avascular Necrosis (AVN) of the Coccyx as a Cause of Coccydynia (Tailbone Pain)
Abstract : Introduction: Coccydynia (coccyx pain, tailbone pain) has many etiologies. Avascular necrosis (AVN, osteonecrosis) of the coccyx is a rarely reported cause of coccyx pain. Case report: We present a case of a 35-year-old male who presented with complaints of four years of worsening coccyx pain. He had a history of bilat..
- Rehabilitation Models of Mechanisms, Preventions and Treatments of Amyotrophic Lateral Sclerosis Caused by Toxic Invasions
Abstract : Amyotrophic lateral sclerosis (ALS) is an adult-onset, progressive and fatal neurodegenerative disorder; there is no cure for ALS to date and the causes of this degeneration are still unknown. In this..
- Obtaining a clearer perspective on the differently abled: a case study from a Caribbean medical school
Abstract : Movies are used in medical schools for a variety of purposes ranging from learning of professionalism, public health, drug dependence, disability among others. In a medical school in Aruba, Dutch Caribbean movies and activities were used to strengthen learning of communication skills, empathy, professionalism, and deat..
- Audit of Maternity Care Outcomes Using the Moving Average Technique
Abstract: Maternity audits are typically shown as monthly figures. These often show spuriously high or ow values. The aim of this study was to audit maternity outcomes over time by applying the moving average technique. This audit of maternity outcomes was conducted at the Nepean Hospital in Sydney, Australia. Variables included..
- Modeling Working Mechanisms of Human Cochlea
Abstract: To keep healthy people from auditory dysfunction such as hearing loss, tinnitus et al, it is significant to understand the working mechanisms of the cochlea. Bekesy discovered the physical mechanism o..
- Relationship between Caregivers' Socio-Economic Status and Childhood Tuberculosis in Bauchi State, Northeastern Nigeria
Abstract: Background:Childhood tuberculosis (CTB), remains a neglected aspect of the TB epidemic despite accounting for 10% of the global TB burden and being responsible for 210,000 deaths in 2016. Furthermore, TB research, prevention, and control worldwide has predominantly focused on adults, neglecting children 0-14 years o..
- A Novel Statistical Approach to NOAEL: QBEST Applied to Dosing of Ellagic Acid
Abstract: QBEST, a novel statistical method, can be applied to the problem of estimating the No Observed Adverse Effect Level (NOAEL) of a New Molecular Entity (NME) in order to anticipate a safe starting dose for beginning clinical trials. The NOAEL from QBEST (called the QNOAEL) can be calculated using multiple disparate studi..
- Transcatheter Uterine Artery Embolisation as a Treatment for Uterine Adenomyosis: A Case Report
Abstract : Background Transcatheter uterine artery embolisation (TUAE) was reported to be clinically effective in women with uterine adenomyoma (UA) and heavy menstrual bleeding. However, if symptoms remain after TUAE, hysterectomy is ultimately required. Therefore, TUAE has not been officially recognised as a UA treatment. Metho..
- Comparative all-cause and cause-specific mortality for National Basketball Association players, 1970-2012
Abstract: Prior reports of the mortality experience of professional basketball players have suggested that players in the National Basketball Association have mortality rates lower than those of the US general population. Here we analyze NBA player vital data between 1970 and 2012 to provide all-cause and cause-specific standard..
- Let There Be Guideline For Being Too Clean
My opinion: As interestingly brought to light by Svanes et al (2018) [1] and others [2-3], the time has been ripe for eliciting a discussion about the consequences of cleaning when with time, being too clean has been slowly replacing being too dirty [4-5]. To my limited understanding, the mechanical agents may elicit harm within m..
- Video Phone Communication With Patients In Isolation
Abstract: The most stringent isolation precautions (airborne precautions) warrant the most commonly used N95 respirators to be worn by healthcare providers in negative pressure rooms caring for patients suspected or confirmed to be harboring airborne pathogens. However, although N95 respirators aim to protect healthcare provider..
- Audio-Video Recording The Consenting Process With Futuristic Air-Gapped Dedicated Devices
Opinion: As anesthesiologists working in perioperative areas, the question that constantly lingers is how to judge the capacity of perioperative patients to consent for the procedures they are presenting for and the procedures they may need emergently. Even though these questions might not have been traditionally related to ane..
- Progress Bar On ERAS Portal
Opinion: The variable application fees' model of Electronic Residency Application Service (ERAS) might be expecting that the fees per application becoming higher with increasing number of applications per specialty may deter the number of applications per applicant from soaring. However, this ploy to control the number of appli..
- Save The Hands While Saving From Hands
Abstract: There has been escalating stress on hand hygiene to ensure prevention of disease-transmission. However, it is time to concurrently give due consideration to counter-concerns inherent with hand hygiene precautions and hereafter, possibly suggest an alternative solution. Although gloves have been in use as barrier method..
- Incidence of Heparin-Induced Thrombocytopenia and "Argatroban" Dollars At University Hospital In The United States
Abstract : Background: According to published medical literature, there is variable incidence of heparin-induced thrombocytopenia (HIT), a life-threatening pro-thrombotic state, complicating unfractionated heparin (UFH) or low-molecular weight heparin (LMWH) use with immunogenic activation cascade evolving into arteriovenous thro..
- I do not believe (have faith) in this: Can I say NO?: Future of Post-Hire Post-Market-Safety-Surveillance (PMSS) for Physicians
My opinion: When the author had conceptualized post-hire Post-Market-Safety-Surveillance (PMSS) [1] for physicians in general and operating room personnel in particular wherein their co-workers and supporting staff may futuristically rate the individuals in question regarding how likely the rating personnel may consider the rated ..
- nil-per-os (NPO): Can We Address It? With A Loco-Regional-National Database
My opinion: Although the term "Say No To NPO!" has been registered as a trademark by BevMD LLC, California, United States,[1] the American Society of Anesthesiologists (ASA) should envision progressing towards it while balancing the dynamically evolving pros-cons evidence for preoperative hydration-nutrition status with pulmonary ..
- Scopolamine and Sugammadex: Gateway To Litigation In Absence of Patient Education
My opinion: As an anesthesiologist, my personal experience with scopolamine transdermal therapeutic system (TTS) patch as a counter-measure against postoperative nausea and vomiting (PONV) and sugammadex as a rapid reversal agent against neuromuscular blockade is limited. Still, I wonder if these medications can be gateway to liti..
- Self-Pay All Along
My opinion: Being an avid reader, I stumbled onto the health insurance practice of ASO [1]. As a healthcare consumer, it is important to know what ASO is. The acronym ASO stands for "Administrative Services Only" [2], a practice that has figuratively evolved the majority of our employers into becoming our health insurance carriers..
- Gender Differences in Comorbidities of Heart Failure Patients with Preserved or Reduced Left Ventricular Ejection Fraction
Abstract: Introduction/AimThe aim of this study was to establish gender differences in the comorbidities of heart failure (HF) patients both with preserved (HFpEF) or reduced (HFrEF) left ventricular ejection fraction Materials and MethodsThis is a retrospective study including 535 heart failure patients hospitalized in the pe..
- Uterine giant myomectomy: A case report
Abstract: Background Uterine leiomyomas, the most common benign gynecological tumor, usually occur in females of reproductive age. Myomectomy is the preferred surgical treatment in reproductive-aged women who want to retain their uterus. Myomas can range in size from as small as an apple seed to as large as a melon. Giant uterin..
- Gemcitabine-induced haemolytic uremic syndrome: high level of suspicion seems crucial
Letter to the editor: Dear editor, Gemcitabine is an antimetabolite agent used in the treatment of many tumours. The safety profile of gemcitabine is generally mild and it usually displays minimal toxicity in elderly too. Furthermore, its profile of side-effects does not seem to be related to patient’s age. There is no evidence of cumulat..
- Sciatic neuritis due to fibrovascular bands and myxoid neurofibroma. Arthroscopic decompression and excision
Abstract : A 34-year-old lady was referred to our clinic due to a chronic hip and leg pain that did not improve with rehabilitation and after three corticosteroid injections. The MRI showed sciatic neuritis and ..
- Chemotherapy induced oral mucositis: prevention is possible
Abstract : Oral mucositis (OM) is a frequent side-effect of antineoplastic treatments. Patients usually describe the first symptom as burning sensation in the mouth and swelling, erythema or ulceration and pain will follow. These will place them at a higher risk of infection, might impair significantly their nutritional status a..
- Building skills of minority doctoral students to apply health behavior theories: a case study
Abstract: At present, in the United States, there is a dearth of well-trained minority leaders in the field of health behavior research who can develop and test theory-driven behavioral interventions, especially for minority communities. The purpose of this case study was to document the design, development, implementation, and ..
- Biological microworld vis-a-vis astrophysical world of gravitation
Abstract: On completion of few decades of in-house as well as outdoor investigations, the author has come out with the opinion that various little understood phenomena in life science could be compared and explained through gravitation based astrophysical principles. Gravitation plays an extensive role in astrophysical world i..
- Clear Aligners: strenghts and weaknesses
Abstract : Clear aligners are orthodontic devices that use elastic thermoplastic material that applies pressure to the teeth to move into the aligner’s position, which are an alternative to dental braces. They are esthetic, efficient, and comfortable compared to traditional fixed appliance for mild-to-moderate malocclusion. Cle..
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