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Dr. Florian Markowetz

Cancer Research UK
Cambridge Research Institute
Robinson Way

Brief Biography:

since 01/2009
Junior Groupleader in Computational Biology at Cancer Research UK Cambridge Research Institute

07/2006 - 12/2008
Postdoctoral Research in the Lewis-Sigler Insitute for Integrative Genomics at Princeton University, Princeton, USA. Advisor: OG Troyanskaya

01/2002 - 06/2006
Doctoral Student at the Max Planck Institute for Molecular Genetics, Berlin, Germany. Advisors: R Spang, M Vingron

06/1999 - 12/2001
Research Assistant at the German Cancer Research Center (DKFZ), Heidelberg, Germany. Advisor: M Vingron


Research interests:

The Markowetz lab develops algorithms and statistics to leverage complex and heterogeneous data sources for biomedical research. Our main research question is: How do perturbations to cellular networks shape phenotypes?

Natural perturbations like copy number alterations and SNPs can promote cancer development. With our partners at CRI we aim to characterize disruptions of signaling pathways in tumours and to identify genomic alterations that drive tumour evolution.

Experimental perturbations like RNAi are key approaches at the forefront of functional genomics. With international collaboration partners we work on methods to identify signaling pathways and their re-wiring from downstream effects of gene perturbations.


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