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Mr. Jean-Pierre Louboutin

Department of Pathology and Cell Biology
Thomas Jefferson University
1020 Locust street

Brief Biography:

Dr Louboutin, MD, PhD, is a Neurologist interested in neurodegeneration, more particularly the neuropathogenesis of HIV-1. By developing different animal models of HIV-1 Associated Neurocognitive Disorder (HAND), he focused his work on the deleterious effects of HIV-1 envelope glycoprotein gp120 and non-structural protein Tat in the brain (apoptosis, oxidative stress, neuroinflammation, abnormalities of the blood-brain barrier, upregulation of MMPs). SV40-mediated gene delivery of antioxidant enzymes SOD1 and GPx1, assessed in different experimental settings, protected neurons against gp120- and Tat-induced apoptosis and other harmful effects. Another field of interest is viral-based gene transfer/gene therapy in different tissues (i.e., bone marrow stem cells, skeletal muscle) and its interaction with regenerative medicine in a translational context. He is the author of about 80 papers in peer-reviewed journals and 6 chapters in books.


Academic positions:

Research Associate


Research interests:

Stem cell therapy; gene therapy; AIDS; neuroAIDS; oxidative stress; apoptosis; neuromuscular disorders; brain.


What I think of the idea behind WebmedCentral:

It will help the rapid dissemination of knowledge and facilitates the communication and interaction between scientists/physicians.