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Dr. Shailender Kanwar

Research Fellow
Chemical Engineering/Biointerfaces Institute, University of Michigan
NCRC B020 Rm#331W-1, 2800 Plymouth Rd
 

Brief Biography:


At the core of my research pursuits is the simple fact that I am working on research hypotheses, methodologies and technologies that may lay a foundation stone towards developing better future treatments/diagnostics for cancer patients. I am always thrilled to look deeply and try the challenging aspects of translational research- a journey that begins from an idea to discovery and then to clinics.

I am broadly experienced in the basic and translational biomedical research involving experimental cancer therapeutics. Previous projects involved investigating cancer initiation (cancer stem cells), prevention and treatment (identification of novel strategies to eliminate CSCs), and screening of natural as well as synthetic agents to identify candidates with anti-cancer stem cell activity. Identification of molecular pathways used by CSCs and further identification of agents that can either block the pathway(s) or propel the CSCs to differentiate may be helpful in enhancing the sensitivity to chemotherapeutic agents.

Continuing further with a mission to closely examine the role of CSCs in cancer recurrence and metastasis, my current focus is on developing strategies for isolation and studying circulating tumor cells (CTCs) and CSCs in cancer patients using novel micro-/nano-technologies by employing MEMS based platforms. Through current research endeavors I am applying the best of basic science along with bioengineering tools to develop patentable innovative technologies for isolating rare cells and analyzing samples from cancer patients, including identification, characterization and in-vitro functional analysis.

 

Academic positions:


Current Appointment:

1. 8/2011- Present Research Fellow, University of Michigan, Ann Arbor, MI-48109

Previous Appointments:

1. 10/2008-7/2011: Research Associate, Department of Internal Medicine, Division of Gastroenterology, Wayne State University-School of Medicine, John D. Dingell VA Medical Center Detroit, MI
2. 08/2006- 10/2008: Senior Research Fellow (Indian Council of Medical Research) Department of Biophysics, Panjab University, Chandigarh, India
3. 08/2004-10/2008: Guest-Faculty (Honorary), Department of Biophysics, Panjab University, Chandigarh, India
4. 08/2004-07/2006: Project Fellow - Special Assistance Programme of University Grants Commission (India), Department of Biophysics, Panjab University, Chandigarh, India

 

Research interests:


Translational Research/Experimental cancer therapeutics and diagnosis:

Developing Bio-MEMS based assays for early detection and isolation of rare cancer cells (circulating tumor cells and cancer stem cells) and micro-/nano-vesicles from bio-fluids. Utilizing interdisciplinary biomedical approaches to establish strategies for evaluating drug efficacies against CTCs/CSCs, drug-resistance and studying their role in metastasis

 

Any other information:


Publications:

1. P. Sharma, S. S. Kanwar, S. N. Sanyal, “Effect of cationic ionophore monensin on the lipid composition and fluidity of rat epididymal spermatozoal membrane” Drug and Chemical Toxicology 2013, 36: 79-87
2. J. Nautiyal, J. Du, Y. Yu, S. S. Kanwar, E. Levi, A. P. N. Majumdar, “EGFR regulation of colon cancer stem-like cells during aging and in response to the colonic carcinogen dimethylhydrazine” Am J Physiol Gastrointest Liver Physiol 2012, 302: G655–G663,
3. Y. Yu, S. S. Kanwar, B. Patel, Phil-Sun Oh, F. H. Sarkar and A.P.N. Majumdar “MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells”, Carcinogenesis 2012, 33: 1: 68-76
4. J. Nautiyal, S. S. Kanwar, Y. Yu, A.P.N. Majumdar, “Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells” Journal of Molecular Signaling 2011, 6:7
5. Phil-Sun Oh, V. Patel, M. Sanders, S. S. Kanwar, Y. Yu, J. Nautiyal, B. Patel, and A. P. N. Majumdar, “Schlafen-3 decreases stem cell marker expression and autocrine/juxtacrine signaling in FOLFOX-resistant colon cancer cells” American Journal of Physiology - Gastrointestinal and Liver Physiology, 2011 301(2): G347-55
S. S. Kanwar, Y. Yu, J. Nautiyal, B. B. Patel, F. H. Sarkar, S. Padhye and A. P. N. Majumdar, “Difluorinated-curcumin (CDF): A Novel Curcumin Analog is a Potent Inhibitor of Colon Cancer Stem-like Cells” Pharmaceutical Research 2011, 28(4) 827-838
6. J. Nautiyal, S. Banerjee, S. S. Kanwar, B. B. Patel, F. H. Sarkar and A. P. N. Majumdar, “Curcumin enhances dasatinib induced inhibition of growth and transformation of colon cancer cells”, International Journal of Cancer, 2011 Feb 15;128(4):951-61
7. S. S. Kanwar, V. Vaish and S. N. Sanyal, “Altered membrane lipid dynamics and chemoprevention by non-steroidal anti inflammatory drugs during colon carcinogenesis”, Nutrition Hospital aria, 2011 26(5): 1141-1154
8. R. Singh, S. S. Kanwar, P.K. Sood, B. Nehru, “Beneficial effects of folic acid on enhancement of memory and antioxidant status in aged rat brain”, Cell Mol Neurobiology, 2011 31:1, 83-91 (Jan)
9. S. S. Kanwar, Y. Yu, J. Nautiyal, B. B. Patel and A. P. N. Majumdar, “The Wnt/β-catenin pathway regulates growth and maintenance of colonosphere”, Molecular Cancer 2010, 9(1):212
10. J. Nautiyal, Y. Yu, A. Aboukameel, S. S. Kanwar, J. K. Das, B. B. Patel, F. H. Sarkar, A. K. Rishi, R. Mohammad and A. P. N. Majumdar, “ErbB-Inhibitory Protein: A Modified Ectodomain of Epidermal Growth Factor Receptor Synergizes with Dasatinib to Inhibit Growth of Breast Cancer Cells”, Molecular Cancer Therapeutics, 2010; 9(6): 1503–14
11. Y. Yu, S. S. Kanwar, B. B. Patel, J. Nautiyal, F. H. Sarkar and A. P. N. Majumdar, “Elimination of Colon Cancer stem-like cells by the combination of curcumin and folfox” Translational Oncology, 2009, 2, 321–328
12. S. S. Kanwar, Karnati R. Roy, B. Nehru, P. Reddanna and S. N. Sanyal, ”Na+ stimulated Na+/H+ exchange and an unfavorable Ca2+ homeostasis initiate the Cycloxygenase-2 inhibitors induced apoptotic signals in the colonic epithelial cells during the early stage of colon carcinogenesis” Oncology Research, 2009; 18 (5): 243-257
13. N. Behal, S. S. Kanwar, P. Sharma and S. N. Sanyal, “Effect of non-steroidal anti-inflammatory drug etoricoxib on the hematological parameters and enzymes of colon and kidney” Nutrition Hospital aria, 2009, 24(3):326-332
14. S. S. Kanwar, K. Vaiphei, B. Nehru and S. N. Sanyal, “Antioxidative effects of Non-steroidal anti-inflammatory drugs (NSAIDs) during the initiation stages of experimental colon carcinogenesis in rats” Journal of Environmental Pathology Toxicology and Oncology, 2008, 27(2): 89-100
15. N. Behal, S. S. Kanwar, J. Kaur and S. N. Sanyal, “Cyclooxygenase-2 inhibition by etoricoxib modulates plasma membrane fluidity in rat colon” Journal of Environmental Pathology Toxicology and Oncology, 2008, 27(4):295–302
16. N. Mittal, S. S. Kanwar, S. N. Sanyal, “Effect of non-steroidal anti-inflammatory drugs and the pro-carcinogen 1, 2 dimethylhydrazine on the rat intestinal membrane structure and function”, Nutrition Hospital aria, 2008, 23: 439-448
17. N. Mittal, S. S. Kanwar, S. N. Sanyal, “Effect of non-steroidal anti-inflammatory drugs and the pro-carcinogen 1,2 dimethylhydrazine on the antioxidant defense system,” International Journal of Toxicology, 2008, 27: 169-174
18. N. Mittal, S. S. Kanwar, S. N. Sanyal, “The effect of etoricoxib, a cyclooxygenase-2 specific inhibitor on the 1,2-dimethylhydrazine administered rat intestinal membrane structure and function”, Toxicology Mechanisms and Methods, 2008, 18: 53-62.
19. S. S. Kanwar, K. Vaiphei, B. Nehru and S. N. Sanyal, “Chemopreventive effects of non-steroidal anti-inflammatory drugs in the membrane lipid composition and fluidity parameters of the 1,2-dimethylhydrazine induced colon carcinogenesis in rats” Drug and Chemical Toxicology, 2007, 30: 293-309
20. S. S. Kanwar, K. Vaiphei, B. Nehru and S. N. Sanyal, “Chemopreventive effects of non steroidal anti-inflammatory drugs on 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats”, Toxicology Mechanisms Methods, 2007, 17(4): 197-204
21. S. S. Kanwar and B. Nehru, "Modulatory effects of N-acetylcysteine on cerebral cortex and cerebellum regions of ageing rat brain”, Nutrition Hospital aria, 2007, 22 (1):95-100
22. B. Nehru and S. S. Kanwar, “Modulation by N-acetylcysteine of lead-induced alterations in rat brain: reduced glutathione levels and morphology”, Toxicology Mechanisms and Methods, 2007, 17 (5): 289-293
23. S. N. Sanyal, S. S. Kanwar, Pinky Sharma, “Oxidative effects of Na+ specific Ionophre monensin on the rat epididymis”, Drug and Chemical Toxicology, 2007, 30: 411-423
24. P. Nair, S. S. Kanwar and S. N. Sanyal, “Effects of non steroidal anti-inflammatory drugs on the antioxidant defense system and the membrane functions in the rat intestine”. Nutrition Hospital aria, 2006, 21: 638-649
25. S. N. Sanyal, M. Goyal, S. S. Kanwar and S. Kaushal, “Use of phospholipid transfer protein as a probe to study the lipid dynamics and alkaline phosphatase activity in the brush border membrane of human term placenta“, Chemistry and Biodiversity, 2006, 3: 527-534
26. S. N. Sanyal, G. Singh and S. S. Kanwar, “Thermotropic lipid phase transition and the behaviour of hydrolytic enzymes in the kidney cortex brush border membrane”, Chemistry and Biodiversity, 2006, 3: 1102-1115
27. M. Singh, N.R. Kalla, S. S. Kanwar and S.N. Sanyal, “Alterations in oxidative stress related parameters in rat testis following monensin administration”, Toxicology Mechanisms and Methods, 2006, 16: 307-312
28. B. Nehru and S. S. Kanwar, “N- Acetylcysteine exposure on lead induced lipid peroxidative damage and oxidative defense system in brain regions of rats”, Biological Trace Element Research, 2004, 101: 257-264
29. G. Kaur, S. S. Kanwar, R. K. Saini and S. N. Sanyal, “Intestinal lesions in rats with experimental treatment of aspirin, a non-steroidal anti-inflammatory drug”, Asian Journal of Microbiology, Biotechnology and Environmental Sciences, 2007, 9(3): 659-664
30. R. Sehgal, S. S. Kanwar and S. N. Sanyal, “Sensitivity of microsomal glucose-6-phosphatase to the non-ionic detergent nonidet-P40 in rat liver and human term placenta”, Panjab University Research Journal (Science), 2007, 57: 175-187
31. R. Sehgal, S. S. Kanwar and S. N. Sanyal, “Study on the thermal stability of microsomal glucose-6-phosphatase in rat liver and human term placenta in Nonidet-P40 treatment”, Panjab University Research Journal (Science), 2007, 57: 189-201
32. R. Sehgal, S. S. Kanwar and S. N. Sanyal, “Inhibition kinetics of G-6-Phosphatase system with NaF in the Nonidet-P40 treated microsomes in rat liver and human term placenta”. Panjab University Research Journal (Science), 2007, 57: 203-212
33. R. Pathak, S. S. Kanwar and S. N. Sanyal, “Molecular forms of Acetylcholinesterase in the human term placenta”, International Journal Mendel, Millennium Series 16, 2006, 23: 57-58
34. A. Mahajan, S. S. Kanwar, R. K. Saini and S. N. Sanyal, “Effect of ionizing radiation on cellular response in the murine spleenic lymphocytes”, Pollution Research, 2006, 25 (4): 727-736

 

What I think of the idea behind WebmedCentral:


It is a good initiative and was much needed to further the purpose of scientific publications. Wish you all the very best!!

 

Home Page:


http://www-personal.umich.edu/~skanwar/index.html