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Dr. Rama Kotipatruni

Research Scientist
Department of Radiation Oncology
1365 Clifton Rd
 

Brief Biography:


Ph.D. Biochemist with over 5 years of experience in solving problems related to Cancer biology, protein chemistry & molecular and cellular biology. Highly focused, results-driven Postdoctoral Research Associate, with credible experience in cancer Biology, molecular biology, cell biology, microbiology, microscopy, viral transduction, immunology and pathology. Equipped with extensive research background from strategic planning to implementation, with outstanding ability to analyze, evaluate and produce detailed reports on preclinical or critical projects. Expertise in development and application of new molecular biology tools. Strong Biochemical and microbiological background with extensive knowledge in methods of viral / bacterial culture and growth by conventional and latest molecular biology applications. Seasoned success in conceiving viable projects and executing them. Currently working towards the identification and development of novel therapeutic molecules and gene therapy for Human neuronal tumors. Expert in characterization of native proteins from diverse model systems, Tumor biology and physiology, Cancer- 3D cell culture methods, Orthotopic brain tumor model and efficient in carrying out interdisciplinary scientific collaborations and maintaining genial team environment. Good communication and interpersonal skills.

 

Academic positions:


ACADEMIC POSITIONS/EMPLOYMENT 2011- Till to date Research associate Radiation Oncology, Washington University School of Medicine at St. Louis 2008 - 2010 Post-Doctoral Research associate University of Illinois, College of Medicine at Peoria, Peoria, IL, USA. 2007-2008 Post-Doctoral Fellow, Discovery Research Division, Institute of Life Sciences and Hyderabad, India 2006 – April, 2007 Tutor (Internal) for M.Sc Integrated Biology, University of Hyderabad, India. 1998 - 2001 Lecturer in Biochemistry. P.G.Studies, T.J.P.S.College, Guntur, India. EDUCATION 2001 - 2007 PhD Biochemistry, University of Hyderabad, Hyderabad, India. 1996 - 1998 M.Sc. Biochemistry Andhra University, Visakhapatnam, India. 1993 – 1996 BSc. Chemistry, Zoology and Botany, Andhra University, Visakhapatnam, India

 

Research interests:


Cancer Biology - Neuro-Oncology ( Brain tumors), Gene Therapy, Tumor Biology, Translational Medicine and Lung Cancer

 

Any other information:


1: Kotipatruni RP, Ren X, Thotala D, Jaboin JJ. NDRG4 is a novel oncogenic
protein and p53 associated regulator of apoptosis in malignant meningioma cells.
Oncotarget. 2015 May 25. [Epub ahead of print] PubMed PMID: 26053091.


2: Kotipatruni RP, Nagaraju GP. Development of plasmid-lipid complexes for direct
intratumoral injection. Methods Mol Biol. 2014;1139:467-76. doi:
10.1007/978-1-4939-0345-0_36. PubMed PMID: 24619700.


3: Bhave SR, Dadey DY, Karvas RM, Ferraro DJ, Kotipatruni RP, Jaboin JJ, Hallahan
AN, Dewees TA, Linkous AG, Hallahan DE, Thotala D. Autotaxin Inhibition with
PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell
Lines. Front Oncol. 2013 Sep 17;3:236. doi: 10.3389/fonc.2013.00236. eCollection
2013. PubMed PMID: 24062988; PubMed Central PMCID: PMC3775313.


4: Thotala D, Craft JM, Ferraro DJ, Kotipatruni RP, Bhave SR, Jaboin JJ, Hallahan
DE. Cytosolic phospholipaseA2 inhibition with PLA-695 radiosensitizes tumors in
lung cancer animal models. PLoS One. 2013 Jul 19;8(7):e69688. doi:
10.1371/journal.pone.0069688. Print 2013. PubMed PMID: 23894523; PubMed Central
PMCID: PMC3716600.


5: Ferraro DJ, Bhave SR, Kotipatruni RP, Hunn JC, Wildman SA, Hong C, Dadey DY,
Muhoro LK, Jaboin JJ, Thotala D, Hallahan DE. High-throughput identification of
putative receptors for cancer-binding peptides using biopanning and microarray
analysis. Integr Biol (Camb). 2013 Feb;5(2):342-50. doi: 10.1039/c2ib20187a.
PubMed PMID: 23147990; PubMed Central PMCID: PMC3823383.


6: Kotipatruni RR, Nalla AK, Asuthkar S, Gondi CS, Dinh DH, Rao JS. Apoptosis
induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3
signaling in medulloblastoma. PLoS One. 2012;7(9):e44798. doi:
10.1371/journal.pone.0044798. Epub 2012 Sep 12. PubMed PMID: 22984561; PubMed
Central PMCID: PMC3440337.


7: Kotipatruni RP, Ferraro DJ, Ren X, Vanderwaal RP, Thotala DK, Hallahan DE,
Jaboin JJ. NDRG4, the N-Myc downstream regulated gene, is important for cell
survival, tumor invasion and angiogenesis in meningiomas. Integr Biol (Camb).
2012 Oct;4(10):1185-97. PubMed PMID: 22869042.


8: Kotipatruni RR, Dasari VR, Veeravalli KK, Dinh DH, Fassett D, Rao JS. p53- and
Bax-mediated apoptosis in injured rat spinal cord. Neurochem Res. 2011
Nov;36(11):2063-74. doi: 10.1007/s11064-011-0530-2. Epub 2011 Jul 7. PubMed PMID:
21748659.

9. Kotipatruni et al., Characterization of chromatin (nucleoid) from extreme halophilic archaeon Halobacterium salinarium H3 shows no nucleosomal organization. Biochemistry: An Indian Journal.2012 Jan Vol.6 (1).

 

What I think of the idea behind WebmedCentral:


Excellent idea! This is very helpful to connect and serve the scientific community around the globe. Good platform to improve and sharing the knowledge.

 

Home Page:


http://cbd.wustl.edu/research.htm