Submited on: 26 Sep 2010 06:04:56 PM GMT
Published on: 27 Sep 2010 07:15:37 AM GMT
Posted by Prof. Luiza Guilherme on 17 Nov 2010 09:18:45 AM GMT

Based on published data in the last 20-30 years the authors proposed the construction of an incomplete monoclonal antibody which is devoid of FC fragment, capable of recognize the identical autoantigens that lead autoimmune reactions in rheumatic fever/rheumatic heart disease patients.

Their hypothesis is that this monoclonal antibody could be able to block the
autoimmune reactions due to the cross reactivity of S. pyogenes antigens with human
tissues (brain, joints and heart).

Their idea is interesting but not excluded the possibility of a vaccine development as they stated in the item 4, page 4.

Minor points that should be revised
Page 2, second column, last paragraph – to substitute antibodies by antibiotics

The references should be revised – some references although being the same are cited 3 or more times with different numbers (ref 36, 39, 50, 52 and ref 38, 40, 41, 63). In the ref 38 the order of the authors are incorrect.

  • Invited by the author to make a review on this article? :
  • Experience and credentials in the specific area of science: None
  • Publications in the same or a related area of science: No
  • References: None
Report abuse