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Reviews
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Other Comments:
We are trying th conclude and extrapolate from the results of this endurance training /supplementation all within 4 minutes of performance difference. If there is a culmulative effect of Ubiquinol / Ubiquinone on mitochondrial function, it should have been clearly mentioned in the article. The results are disparate and minor metabolic differences or age factors do not seem to strenghten the hypothesis. The need for a 90 days trial period becomes questionable.
Change of "study" to "case report" is merely cosmetic and adds no insight.
There is little weight to conduct formal controlled strudies.
There is a heavy bias in the hypothesis.
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
Nil
- How to cite: Gupta V K.Confusion and endurance running: premature conclusions. [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001165
Responded by Dr. Bill Misner on 27 Nov 2011 11:05:53 PM
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Other Comments:
This is the fourth version of this article; it has been extensively revised in response to reviews of the previous version. It reads much better now, and the organization is much improved over previous versions.
The author clearly describes the findings as interesting without drawing definite conclusions. I agree that further research with more subjects (and blinding of investigator/subject) would be worthwhile.
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Competing interests:
None
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Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
Yes
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References:
None -
Experience and credentials in the specific area of science:
Experienced runner (have completed > 30 marathons)
- How to cite: Herchline T .Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report Published 8 Nov 2011[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001154
Responded by Dr. Bill Misner on 23 Nov 2011 04:17:52 AM
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Other Comments:
It proves an interesting study, although lacking of a further examination of an evaluation of blood hematochemical parameters and of statistics. A table might be more informative.
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Competing interests:
None
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
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Experience and credentials in the specific area of science:
Benoni G, Bellavite P, Adami A, Chirumbolo S, Lippi G, Brocco G, Cuzzolin L.
Effect of acute exercise on some haematological parameters and neutrophil
functions in active and inactive subjects. Eur J Appl Physiol Occup Physiol.
1995;70(2):187-91Benoni G, Bellavite P, Adami A, Chirumbolo S, Lippi G, Brocco G, Giulini GM,
Cuzzolin L. Changes in several neutrophil functions in basketball players before,
during and after the sports season. Int J Sports Med. 1995 Jan;16(1):34-7 - How to cite: Chirumbolo S .An interesting paper but lacking of some further data[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001149
Responded by Dr. Bill Misner on 21 Nov 2011 07:16:30 PM
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Other Comments:
Some elements of data presentation appeared under the section for Methods. These should all be expunged or moved to the section under Results. The methods employed only were meant to be presented here.
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Competing interests:
none
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
Teach the biochemistry course "Metabolic Regulations" for quite sometimes now.
- How to cite: Adeyemi O S.Coenzyme Q-10 Effects Endurance Runner's Performance - A Case Report [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001139
Responded by Dr. Bill Misner on 16 Nov 2011 05:48:36 PM
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Other Comments:
Now the paper fits well!
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Competing interests:
no
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
! am a nutrologist involved with food and suplement issues.
- How to cite: Bedin V .Coenzime Q-10 Effects Endurance Runner`s Performance - A Case Report[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001131
Responded by Dr. Bill Misner on 15 Nov 2011 05:50:06 PM
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Other Comments:
Coenzyme Q-10 in combination with other drugs are likely to be effective for improvement in general well being, in prevention or management of heart diseases, diabetes and other metabolic disorders.
This is an interesting case report where the author who is himself the subject has studied the effects of Coenzyme Q-10 on endurance runner's performance.
This study has been well planned, executed and needs to be appreciated.
This study has raised an important question regarding the benefits of Ubiquinone loading protocol.
As this is carried out on a single subject, the reported effects have to be confirmrd on larger population. And also the gender variations,dosage specification, any other physiological changes can be studied.
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Competing interests:
No
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
I have worked and published articles on the effects of diet on cardiometabolic disorders.
- How to cite: Dutt. R A .Review on "Coenzyme Q-10 Effects Endurance Runner's Performance - A Case Report "[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001111
Responded by Dr. Bill Misner on 09 Nov 2011 07:26:22 PM
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Other Comments:
The final revised paper can be accepted for publication.
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Competing interests:
No
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
Worked in bioequivalence studies on novel drug delivery systems
- How to cite: Kulkarni G T.Final revision - Coenzyme Q-10 Effects Endurance Runner's Performance - A Case Report[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001109
Responded by Dr. Bill Misner on 08 Nov 2011 09:33:16 PM
Previous Version:
Coenzyme Q-10 Effects Endurance Performance - A Case Report
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Other Comments:
Quality of the manuscript has been improved drastically. Eventhough one correction hasve to rectify by the authors. Methods section replaced by refernces, so authors are requested to upload file with appropriate methods.
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Competing interests:
None
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
Nil
- How to cite: Venkatachalam K .Second review [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001087
Responded by Dr. Bill Misner on 02 Nov 2011 06:03:58 PM
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Other Comments:
i must appreciate author effort.
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Competing interests:
no
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
muscle, bone physiology and nutrition
- How to cite: Singh B P.Coenzyme Q-10 Effects Endurance Performance - A Case Report[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001085
Responded by Dr. Bill Misner on 02 Nov 2011 03:06:57 AM
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Other Comments:
This revision is much improved.
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Competing interests:
No competing interests to declare.
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Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
Background in nutrition.
- How to cite: Zanovec M .Second review of a case report[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001083
Responded by Dr. Bill Misner on 01 Nov 2011 08:53:26 PM
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Other Comments:
Dr. Misner improved the text significantly. We are now convinced that this report opens “the doors” to a “true” study.
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Competing interests:
none
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Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
No
- How to cite: Stevanovic D .Improved[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001082
Responded by Dr. Bill Misner on 01 Nov 2011 03:47:48 PM
Previous Version:
Coenzyme Q-10 Effects Endurance Performance - A Case Report
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Other Comments:
This report adds new information to the literature. It is an interesting topic.
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Competing interests:
No
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
Yes
- How to cite: Aribas B .Coenzyme Q-10 Effects Endurance Performance - A Case Report[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;3(1):WMCRW001362
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Other Comments:
Dear M?sner,
It is succesful
This can be added into Conclusion: This Case Report is inconclusive, calling for more research with larger populations to determine whether or not oral dose Ubiquinol or Ubiquinone has any effect on energy performance.
Also, some of introduction can be moved to discussion.
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Competing interests:
No
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
I am experienced as a medicne doctor in oncology hospital.
- How to cite: Aribas B .Coenzyme Q-10 Effects Endurance Performance - A Case Report [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(12):WMCRW001221
Responded by Dr. Bill Misner on 10 Jan 2012 03:25:23 PM
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Other Comments:
As a case study, this paper is informative and well written, but just as also pointed out by the author, the study is not conclusive with its current setting. A more carefully design with statistical power is necessary for the further research examining exogenous Coenzyme Q10 dose effects.
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Competing interests:
No.
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Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
N/A
- How to cite: Feng F .a well-written case study, but nothing conclusive.[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001106
Responded by Dr. Bill Misner on 08 Nov 2011 04:33:58 PM
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Other Comments:
Dear Dr. Misner:
I found your new manuscript now acceptable. You work hard to get a better manuscript. I think with time you will build an acceptable protocol to get better data on the use of this enzyme.
Dr. Constantino Ledesma-Montes.
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Competing interests:
None.
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
None
- How to cite: Ledesma-Montes C .Review on the manuscript. Coenzime Q-10. Effects, endurance, performance-A case report,[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001086
Responded by Dr. Bill Misner on 08 Dec 2012 05:46:40 PM
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Other Comments:
Dear Dr. Misner:
I read your new manuscript and found it more acceptable, unfortunately it is a one case series, but you have contact with this kind of patiens and have the opportunity to build a well-done protocol in the future. I thing you will be succsessful with your work.
Sincerely.
Dr. Consatntino Ledesma-Montes.
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Competing interests:
None.
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
None
- How to cite: Ledesma-Montes C .Review on the manuscript. Coenzime Q-10. Effects, endurance, performance-A case report,[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(11):WMCRW001084
Responded by Dr. Bill Misner on 08 Nov 2011 04:29:18 PM
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Other Comments:
Dear Bill,
You are reporting an interesting case about a previously unexplored effect of coenzime Q10. I'm concerned with the magnitude of the effect. I doesn't seem that a ±2% variation in performance with treatments is significant enough to warrant further research.
Additionally, why did you chose a 14-d wash out period? coenzime Q10 biological effects may last longer.
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Competing interests:
none
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
I'm a pharmacoepidemiologist with expertise in medical physiology.
- How to cite: Perez Lloret S .revision[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001080
Responded by Dr. Bill Misner on 31 Oct 2011 04:27:49 PM
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Other Comments:
This is a very interesting, meticulously written article. However, I do have some points to make regarding the structure and overall readability and organization of the manuscript. (Note that this is me attempting to help turn a fascinating scientific study into a well-written and excellently presented article).
In the introduction, there is quite a lot of repetition (esp. concerning the absorbance of Ubiquinone and Ubiquinol). There is a list, followed by paragraphs comparing the two - in some places this can sound redundant. The order followed in the introduction, beginning with comparing the two forms and THEN mentioning the functions of Coenzyme Q10 endogenously seems inappropriate. Starting broader by talking about CQ10 first (functions, nature, etc) and then it's forms and the differences between them would make it much more readable.
The terms ''Not-healthy'' and ''healthy'' are inappropriate to describe high and low-fat foods respectively - they are not synonymous.
The first sentence in the Methods section should be included in the introduction. A justification (or an attempt at one) for specifically selecting a 14-day washout period would also improve this section.
The discussion should be before the conclusion, and more emphasis should be placed on comparing the results with other similar studies (in animals or humans) in the discussion. The discussion should be based on sentences such as ''Because aging and exercise create a deficiency ... etc'' rather than simply state facts about CoQ10 as has been done in the beginning of the discussion - most of this information would be better placed in the introduction. Otherwise, correlates between these facts and the results of the study should be considered.
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Competing interests:
None
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
N -
Experience and credentials in the specific area of science:
Basic
- How to cite: Khalil A A.Review of the article: Coenzyme Q-10 Effects Endurance Performance - A Case Report [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001079
Responded by Dr. Bill Misner on 31 Oct 2011 04:14:36 PM
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Other Comments:
In this revised form, the author greatly improved his ms. I suggest to move the Discussion section before the Conclusions one
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Competing interests:
no
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
no
- How to cite: Iriti M .Coenzyme Q-10 Effects Endurance Performance - A Case Report [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001078
Responded by Dr. Bill Misner on 31 Oct 2011 04:04:06 PM
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Other Comments:
It is an important case report
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Competing interests:
No
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
I am concerned with nutritional facts and aging.
- How to cite: Bedin V .Review of Revised Paper: Coenzyme Q-10 Effects Endurance Performance - A case report[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001073
Responded by Dr. Bill Misner on 30 Oct 2011 04:31:08 PM
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Other Comments:
The article has made a good correlation between coenzyme Q10 and food. It adds up to the present knowldege and hence can be accepted.
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Competing interests:
No
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
I was also involved in clinical trials and case studies concerned to novel drug delivery systems
- How to cite: Kulkarni G T.Review of Revised Paper: Coenzyme Q-10 Effects Endurance Performance - A Case Report[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001070
Responded by Dr. Bill Misner on 29 Oct 2011 05:50:34 PM
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Other Comments:
a very informative paper which is contributing the research on Coenzyme Q10 its presence and absence related to food and how essential for day to day life and it is related to cardiac diseases which are epidemic underway so the report is very much important in current science for corelation between antioxidant, degenerative diseases and cardiovascular diseases.
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Competing interests:
These co-enzyme if worked out definitely root out the degenerative diseases, also as these are working on stress release.
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
No, not exactly as i am working on Indian Medicinal Plants and their biopotentials so indirectly related to these diseases to cure them by various herbs.
- How to cite: Menghani E .Coenzyme Q-10 Effects Endurance Performance - A Case Report[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001069
Responded by Dr. Bill Misner on 29 Oct 2011 04:38:28 PM
- Other Comments: I am basing my comments mainly from my experience in the field of medicine. I am not sure if other discipline may have differing view. When one reports a case, it represents among others; a perceived novel entity, a rare disorder that may not be rare after all or an unusual presentation of a common entity. Nevertheless, they all share a common theme, that is a naturally occuring phenomenon or at the most an unintended consequence of our action. The report is submitted, in the context that perhaps others may have also experience a similar situation or at least be alert of it. Perhaps in due time, a pattern is revealed. In this report, a specific act was delibrately inserted to evaluate a response. This is an interventional study, involving consumption of either Ubiquinol or Ubiquinin or none at all. It looks like an attempt to do a cross over study. When an interventional study is carried out, then the rules governing such a study has to be applied. When studies are carried out without adhering to proper research methodology and statistical rules, we end up with misintrepetation, fallacies and worse still uninterpretable data. A single subject study do not tell us anything. >> Each phase of the study was pretty long, 90 days. The best-timed run for phase 1 was in April and phase 2 was in August, 2011. The author has not detailed the exact period for each phase. I believe in a temperate climate, dietary habits changes with the seasons. In the tuskegee study, there was almsot 30% drop in food consumption by weight in winter compared to spring, mostly due to dropped in consumption of animal products (55%).( Robert T. Dirks and Nancy Duran, 2001) The author of this study (auth herein) has mentioned in the introduction that co-enzyme A level is influenced by consumption of fatty food. Has the auth standardized the dietary intact during all three phases of study. It would have been better if serum Q10 level was also quantified during the study. This would have given a better correlation between performance in each phases and the level of Q10, if that is what the author wish to study. This brings us to the next issue. >> The auth has not specified the research question. This is a fundamental step in any hypothesis driven empirical research. The research methodology design depends on the research question. >> The auth had presented his result as best of 12 runs in phase 1, best of 8 in phase 2 and a single run in phase 3. The agreed method of presenting such data would be central tendencies and its associated intervals. All these run-time values may be just a difference by chance, which we could statistically evaluate by repeated measure ANOVA. . >> The subject was not blinded. The subject has complete control on the conduct of his run with full knowledge of which supplement he has taken. This is a recipe for bias. >> There should be a washout period between phase 1 and 2. >> There are other issues as well but it becomes irrelevant when the core issues is at fault. The auth stressed that no conclusion is made for this study. However the displayed result indirectly imply to some that maybe a shorter time was achieved during phase 2. This is totally erronous. Besides every manuscript must have a take home message, i.e some form of conclusion. Otherwise it should not be written in the first place, as others could not benefit from the write up. In the end, I believe this manuscript has not provided us any additional knowledge compared to where it began. WMC has an open policy of accepting and publishing all manuscript. The responsibility now rest on the writers to evaluate his or her own paper before submitting. It is my personal opinion that authors should refrain from publishing interventional study of single subject. P.S. my comments has been purely in an academic context. I apologize for being less than tactful Reference Robert T. Dirks and Nancy Duran (2001) African American Dietary Patterns at the Beginning of the 20th Century. J. Nutr. 2001 131: 7 1881-1889
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Competing interests:
None
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
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Experience and credentials in the specific area of science:
None - How to cite: Dzarr A .An appraisal of article titled, Coenzyme Q-10 Effects Endurance Performance - A case report (Modified version) [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001066
Responded by Dr. Bill Misner on 29 Oct 2011 04:06:58 AM
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Other Comments:
This article has been extensively revised in response to reviews of the previous version. It reads much better now, although the organization is still somewhat awkward (Conclusion before discussion, some parts of the discussion would be more appropriate in the introduction and visa versa).
The author now clearly describes the findings as interesting without drawing any conclusions. I agree that further research with more subjects (and blinding of investigator/subject) would be worthwhile.
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Competing interests:
None
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Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
Yes
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References:
Herchline T .Coenzyme Q-10 and Endurance Performance[Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001028 Herchline T .Coenzyme Q-10 and Endurance Performance - Updated Review[Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001043 -
Experience and credentials in the specific area of science:
Experienced runner (have completed > 30 marathons)
- How to cite: Herchline T .Coenzyme Q-10 and Endurance Performance - Review of Revised Report[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001064
Responded by Dr. Bill Misner on 29 Oct 2011 02:32:16 AM
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Other Comments:
A study where the subject was blinded to the intervention would have improved its validity.
It willalso be useful to report the variance in running time in the different attempts with each of the interventions. Statistical significance can then be tested.
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Competing interests:
None
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Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
No experience in this specific area of science
- How to cite: Puliyel J .The absence of blinding is a problem[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001063
Responded by Dr. Bill Misner on 29 Oct 2011 02:30:26 AM
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Other Comments:
This version is much better than the first. My main criticism still has not been answered: data is presented as the best time in each category, instead of the mean and standard deviation in each group. It would be interesting to see if, when presented in this manner, the same conclusions could be made.
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Competing interests:
No
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
Yes
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References:
None -
Experience and credentials in the specific area of science:
Professor of Medicine, Specialist in Endocrinology and Metabolism
- How to cite: Shenkman L .Coenzyme Q-10 Effects Endurance Performance - A Case Report[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001062
Responded by Dr. Bill Misner on 28 Oct 2011 03:38:52 PM
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Other Comments:
You did well to change from case study to report. Your last setence in Conclusion section says it all. That sentence already takes care of the limitations inherent in the report. I think there is serious need to conduct this study on a wider scale or like you said for all ages then the results generated hereafter would have either helped to substatiate the present study's effectiveness or otherwise.
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
very exciting and challenging
- How to cite: Nwankwo B O.Coenzyme Q-10 Effects Endurance Performance - A Case Report[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001061
Responded by Dr. Bill Misner on 28 Oct 2011 03:35:50 PM
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Other Comments:
In this single case study, the authors reported the effect of Ubiquinone on performance of 71 years old male subject. This observation is of great interest but still some questions remain to be answered before going to large clinical studies.
This article is well designed and written however two points should be taken into consideration: 1) the introduction is too long and is not focused on previous studies. 2) the discussion appear particularly weak and seems a repetition of the Introduction.
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Competing interests:
None
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
Clinical Trials
- How to cite: Hmadcha K .Coenzyme Q-10 Effects Endurance Performance - A Case Report [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001057
Responded by Dr. Bill Misner on 28 Oct 2011 03:34:59 PM
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Other Comments:
Introduction is too long. It is better to be shortened for scientific purpose.
Other sections are well written and adequate.
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Competing interests:
No
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
I am experienced as a medicne doctor in oncology hospital.
- How to cite: Aribas B .Coenzyme Q-10 Effects Endurance Performance - A Case Report[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001055
Responded by Dr. Bill Misner on 28 Oct 2011 03:34:19 PM
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Other Comments:
The reviewer has no big problems with the manuscript. It seems correctly designed and well done experiment showing new interesting data. Discussion is rather comprehensive.
-The Author has mentioned as Ubiquinone and/or Ubiquinol play an important role regenerating two internal antioxidants, vitamin E and vitamin C. But the none of the antioxidants was measured- Justify
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Competing interests:
NONE
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
Antioxidants
- How to cite: Venkatachalam K .Coenzyme Q-10 Effects Endurance Performance - A Case Report [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001054
Responded by Dr. Bill Misner on 28 Oct 2011 03:33:15 PM
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Other Comments:
now, i think this article is presented well.
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Competing interests:
no
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
experience in muscle force and bone strenth research
- How to cite: Singh B P.Coenzyme Q-10 Effects Endurance Performance - A Case Report [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001053
Responded by Dr. Bill Misner on 29 Oct 2011 02:16:26 AM
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Other Comments:
Single-case studies are always welcome before conducting “real” ones (clinical trials, follow-up studies, on similar), because we learn not only about possible/desirable outcomes, but moreover about all possible mistakes, obstacles, and difficulties to avoid later. This study is of significant importance considering that it brings new perspectives on researching Ubiquinol or Ubiquinone and anaerobic exercising, but I feel that the author encountered some difficulties, he needs to avoid in a later project. I think that the issues arose during the study are of greater importance than technical ones with its presentation.
- Shorter abstract is preferred. Like “This case study evaluated the running performance of a 71-year male runner while taking Ubiquinol, or Ubiquinone, each for 90-days, or taking neither supplement following a 14-day washout period. The subject best performance time on the same course while taking Ubiquinone was 2.28% faster than his time on the same course after a 14-day washout period no-supplement dose. The subject best performance time on the same course while taking Ubiquinol was –1.16% slower than his time on the same course after a 14-day washout period no-supplement dose.” This is the key note!
- In the intro, details of the previous studies that evaluated the drug and physical exercise should be given. However, what was written in the discussion is actually the content of the intro.
- The aims of the study are missing and what the hypothesis is. This need to be clearly stated, whereas it will be the aim of the further research.
- It needs to be clearly stated why including a 71-year old male. Why not including a younger individual? We need to know the entire health status of that individual as well.
- You need to state in the discussion what are the implications of these findings and how they relate to the context of this drug. You need to give what should be the next step.
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Competing interests:
None
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
I have experiance in physical activities in epilepsy, but none in this field.
- How to cite: Stevanovic D .Single-case studies are always welcome before conducting “real” ones [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001050
Responded by Dr. Bill Misner on 28 Oct 2011 03:30:44 PM
Previous Version:
Coenzyme Q-10 Effects Endurance Performance - A Case Study
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Other Comments:
Clinical trials on single subjects are helpful before actually proceeding with case control studies on a larger samples. In relation to the present study, I suggest the following:
1. A placebo drug could have been tried on an age matched control after assessing the fitness.
2. Double blinding would have erradicated bias.
3. The placebo could have been tried on the same case subject between the phases, with wash out periods between each phase.
4. A case control study with larger sample size is welcome as the results are promising.
The reviews are posted to strenthen the article and the study.
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Competing interests:
None
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
none.
- How to cite: Rao K .review of revised version of -Coenzyme Q-10 Effects Endurance Performance - A Case Study [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001072
Responded by Dr. Bill Misner on 30 Oct 2011 04:24:22 PM
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Other Comments:
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I believe that the author should increase control and case group subjects. Despite being a case report the aim of this paper is greater than this.
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The discussion and conclusion need to be more detailed.
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Competing interests:
no
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
I am a professor of medicine with a nutritional teaching backgound
- How to cite: Bedin V .Coenzyme Q-10 effects endurance performance - A case study[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001044
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Other Comments:
Reference section has been added; references are appropriate for the article.
Regarding the statement in the abstract "For these results for one subject male 71-years to be conclusive the trend should further confirmed or denied by examining dose and performances associated from a larger contingent of male and female runners over age 40", wording implies that a trend was observed. It is not appropriate to refer to results from a single subject as a "trend."
The information preceding the Methods section would be better titled "Introduction."
There should be a "Discussion" section following the results. It would be useful to include some of the comments that have been included in the author's responses to the reviews.
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Competing interests:
None
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
Yes
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References:
Herchline T .Coenzyme Q-10 and Endurance Performance[Review of the article 'Coenzyme Q-10 Effects Endurance Performance - A Case Study ' by Misner B].WebmedCentral 2011;2(10):WMCRW001028 -
Experience and credentials in the specific area of science:
Experienced runner (have completed > 30 marathons)
- How to cite: Herchline T .Coenzyme Q-10 and Endurance Performance - Updated Review[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001043
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Other Comments:
The paper is well written. The study is well planned. Addition of little more discussions would make this paper still better.
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Competing interests:
No
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
I was also involved in clinical trials and case studies concerned to novel drug delivery systems.
- How to cite: Kulkarni G T.Coenzyme Q-10 Effects Endurance Performance - A Case Study[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001037
Responded by Dr. Bill Misner on 08 Dec 2012 05:44:50 PM
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Other Comments:
It is difficult to draw conclusions from the way this data data was presented. The statistical tests carried out to determine significance were not stated. The use of percentages alone can be very deceptive in arriving at scientific conclusions. And the discussions should come after the results.
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Competing interests:
NONE
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
I have geriatric patients in the intensive care on ubiquinone therapy from their physician. The marginal benefit of this drug is still not very clear
- How to cite: Ajuzieogu O V.Coenzyme Q-10 Effects Endurance Performance-A Case Study[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001036
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Other Comments:
author must increase control and case group subjects. without increasing subjects author can not reach at any conclusion as happen in this study. discussion and conclusion need to described in detail.
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Competing interests:
no
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
experienced in muscular movements and physiology
- How to cite: Singh B P.Coenzyme Q-10 Effects Endurance Performance - A Case Study [Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001032
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Other Comments:
This is a trial with N=1, a single subject. No conclusions can be made from the data presented.
There are references within the body of the article, but no section at the end of the paper for listed references.
There are conclusions presented in the abstract, but no section for conclusions following the results. Further, the section labeled "Discussion" is actually an introduction.
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Competing interests:
None
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
Experienced runner (have completed > 30 marathons)
- How to cite: Herchline T .Coenzyme Q-10 and Endurance Performance[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001028
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Other Comments:
The data presented do not support the conclusions. It would have been useful to see the actual times for each run in each of the three categories. Running times should have been presented as the mean and SD of each category, and not as the best time in each category.
the structure of a standard paper contains the Discussion at the end, not prior to Methods and Results.
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Competing interests:
No
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
Yes
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References:
Eliakim A, Nemet D and Shenkman L. Serum enzyme activities following long-distance running: comparison between Ethiopian and white athletes. Isr. J. Med. Sci. 1995; 31: 657-659. -
Experience and credentials in the specific area of science:
Professsor of medicine, specialist in internal medicine and endocrinology and metabolism
- How to cite: Shenkman L .Coenzyme Q-10 Effects Endurance Performance - A Case Study[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001026
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Other Comments:
This case study is well documented and the manuscript is well-written and provides a thorough introduction and background. Suggest adding a few comments after the Results section to conclude and discuss implications and suggestions.
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Competing interests:
No competing intersts to declare.
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
Yes
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References:
Daray LA, Henagan TM, Zanovec M, Earnest CP, Johnson LG, Winchester J, Tuuri G, Stewart LK. Endurance and resistance training lowers C-reactive protein in young, healthy females. Applied Physiology, Nutrition, and Metabolism, 2011, 36:660-670, 10.1139/h11-077. -
Experience and credentials in the specific area of science:
Background in kinesiology and nutrition and former marathon runner.
- How to cite: Zanovec M .Review of case study[Review of the article 'Coenzyme Q Effects the Endurance of the Runner Performance: A Case Report ' by Misner B].WebmedCentral 2011;2(10):WMCRW001025
Responded by Dr. Bill Misner on 29 Oct 2011 02:36:03 AM
The article made interesting reading. It could be an initiation for further research on the subject. More research into complementary and alternative treatment options would help due to their proven efficacy and safety.
none
No
No
None
Role of enzymes and coenzymes in health and disease
Responded by Dr. Bill Misner on 09 Dec 2011 11:28:03 PM