Submited on: 12 Dec 2011 06:06:11 AM GMT
Published on: 12 Dec 2011 03:49:07 PM GMT
 

  • What are the main claims of the paper and how important are they?

    This manuscript describes the Sanguinarine, Hydroxybutyrate Dehydrogenase and Fatigue in Epidemic Dropsy. It is interesting.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    It is novel?


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    The results support the claims?


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

     The methodology is valid?


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    The authors should add what supportive measures and antioxidants had been used.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes


  • Other Comments:

    No.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:

    None

  • Experience and credentials in the specific area of science:

    I had studied the similar topic.

  • How to cite:  Liu C .Sanguinarine, Hydroxybutyrate Dehydrogenase and Fatigue in Epidemic Dropsy: A Retrospective Study of an Outbreak and its Control from Gujarat, India[Review of the article 'Sanguinarine, Hydroxybutyrate Dehydrogenase and Fatigue in Epidemic Dropsy: A Retrospective Study of an Outbreak and its Control from Gujarat, India ' by Amin B].WebmedCentral 2012;5(3):WMCRW003012
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Anti-oxidants were Vitamin C & E.

Supportive measures were admission, avoidance of the said oil; B complex vitamines and treatment of fever and  anemia.


Responded by Prof. Jayendra R Gohil on 03 Mar 2014 05:55:59 AM
Gohil review
Posted by Dr. Marie Bourgeois on 21 May 2012 12:43:13 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    interesting report

  • Competing interests:
    none
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    none

  • How to cite:  Bourgeois M .Gohil review[Review of the article 'Sanguinarine, Hydroxybutyrate Dehydrogenase and Fatigue in Epidemic Dropsy: A Retrospective Study of an Outbreak and its Control from Gujarat, India ' by Amin B].WebmedCentral 2012;3(5):WMCRW001831
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? No
5 Are structure and length satisfactory? No
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? Yes
7 Can you suggest any reductions in the paper, or deletions of parts? Yes
8 Is the quality of the diction satisfactory? No
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? No
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Title of the article can be changed to "Clinical profile of Epidemic dropsy patients".  Type of study has not been mentioned. A case definition could have been included. Place of estimation of HBDH and sanguinarine has not been mentioned. Authors should concentrate only on the clinical profile of epidemic dropsy patients. There are so many references at the end, however all are not used in the text.

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I am mainly involved in the field of Public health research. 

  • How to cite:  Verma P B.Sanguinarine, Hydroxybutyrate Dehadrogenase and Fatigue in Epidemic Dropsy: A retrospective study of a n outbreak and its control from Gujarat, India.[Review of the article 'Sanguinarine, Hydroxybutyrate Dehydrogenase and Fatigue in Epidemic Dropsy: A Retrospective Study of an Outbreak and its Control from Gujarat, India ' by Amin B].WebmedCentral 2012;3(3):WMCRW001539
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It is a retrospective study [mentioned in title].

Estimation of HBDH and sanguinarine were done at Toxicology laboratory [ICMR], Lucknow, UP, India.

Reference 13-15 are mentioned with table 3 cardiac manifestations.

Case definition: Epidemic dropsy is a clinical state resulting from consumption of edible oils adulterated with Argemone Mexicana seed oil [due to toxin sanguinarine or dihydrosanguinarine].


Responded by Prof. Jayendra R Gohil on 03 Mar 2014 06:04:07 AM