Submited on: 01 Jun 2012 04:00:38 PM GMT
Published on: 02 Jun 2012 05:20:34 PM GMT
Malignancies after Liver Transplantation
Posted by Dr. Emad Bakir on 17 Jun 2012 02:55:19 PM GMT

  • What are the main claims of the paper and how important are they?

    The main claim of this paper is to show the relationship between the liver transplatation surgery, the post transplantation immune suppression and previously aquiered chronic viral infections especially the epstein barr virus, which become active post immune surppression and manipulate the DNA resulting in malignancies for example lymphoma.

    The Paper stress the role of multi factural theory in developing cancers post immune surpression depending on environment, genes sex and of course age, between the different groups of cancers.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    This claim is novel because this claim is much studied and outsoursed in recent years and in the era of newly developed immune surppression medicine, however long term studies are needed and further long term data is necessary to stress and proove the relationship


  • Are the claims properly placed in the context of the previous literature?

    Of courseas this build the back rad for teaching in this area, and may lead to changes in the management.

    We know thatliver transplatation surgery is one of the most complex and further studies and research are paramount to improve outcome and long term survival rates


  • Do the results support the claims? If not, what other evidence is required?

    Yes but of course this is a review and depend on the previous research performed by different international groupes.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    Does not apply



  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yesas this is a very effecient way toget result by reviewing of multiple international and national studies to detect common results and contradective issues and then recommend further study and research subjects.



  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Yes further research and long term studies


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Itis an exellent paper, however it is a review and stress the need of further experiments and new studies with different design



  • Other Comments:


  • Competing interests:
  • Invited by the author to review this article? :
  • Have you previously published on this or a similar topic?:
  • References:

    I am a consultant Radiologist with GI and Hepatobiliary subspeciality,I published on Hepato cellular carcinoma in RSNA

  • Experience and credentials in the specific area of science:
  • How to cite:  Bakir E .Malignancies after Liver Transplantation[Review of the article 'Malignancies after Liver Transplantation: A Review of the Literature ' by Venyo A].WebmedCentral 2012;3(6):WMCRW001934
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