Submited on: 01 Nov 2012 09:13:46 AM GMT
Published on: 01 Nov 2012 02:36:23 PM GMT
 
Does EPP Oscillations Relate to Tremors?
Posted by Dr. Sanjoy Sanyal on 29 Nov 2012 12:34:09 AM GMT

  • What are the main claims of the paper and how important are they?

    1. Determining the location of Neuromuscular junction in Masseter and Temporalis muscles;

    2. Determining if there is any relationship between EPP oscillations and tremors


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    Not conclusively for Temporalis muscle NMJ and the mechanism of tremors.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    Only 6 subjects were used. No RCT


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    More experients would be required, with larger number of subjects and controls.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Not outstanding, but it paves the way for other more advanced work. I would not use it in my lectures.


  • Other Comments:

    Generally, a commendable effort on the part of researchers!

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I have been lecturing medical students on these and related topics for the last 8 years in medical universities in Seychelles and the Caribbean.

  • How to cite:  Sanyal S .Does EPP Oscillations Relate to Tremors?[Review of the article 'Synchronization Among Endplate Potential Oscillations in Jaw Closing Muscles ' by Kumai T].WebmedCentral 2012;3(11):WMCRW002356
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  • What are the main claims of the paper and how important are they?

    Activities from both anterior temporalis and masseter muscles were recorded in six adult subjects during tooth clenching. The endplate potential pattern with average frequency of 30 Hz, extracted from raw EMG, occured to be synchronized. The author conclude, that there could by a neural mechanism involved in cooperation of jaw closing muscles, manifested by synchronization.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes


  • Are the claims properly placed in the context of the previous literature?

    Almost, especially based on author's own publications


  • Do the results support the claims? If not, what other evidence is required?

    Yes


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No, I do not see them


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    See my next answer


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    This paper describes few novel directions in its discipline. However, next investigation with more subjects involved and comparison with other literature resources is needed. 


  • Other Comments:

    No

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:

    Partially, analysis of EMG and ENG activity involved in neuronal determinants of respiration: KNOCIKOVA, J. Time-frequency energy distribution of phrenic nerve discharges during aspiration reflex, cough and quiet inspiration. In Computer Methods and Programs in Biomedicine. 2011, vol. 102, no. 1, p. 81-90. KNOCIKOVA, J. et al. Wavelet analysis of electrical activities from respiratory muscles during coughing and sneezing in anaesthetized rabbits. In Acta Veterinaria Brunensis. 2009, vol. 78, no. 3, p. 387-397.

  • Experience and credentials in the specific area of science:
    None
  • How to cite:  Knocikova J .Synchronization Among Endplate Potential Oscillations in Jaw Closing Muscles[Review of the article 'Synchronization Among Endplate Potential Oscillations in Jaw Closing Muscles ' by Kumai T].WebmedCentral 2012;3(11):WMCRW002330
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  • What are the main claims of the paper and how important are they?

    EMGs (electromyograms) in tooth clenching were recorded from both sides of the anterior temporalis and masseter muscles of 6 subjects. The oscillations of the neuromuscular synaptic potential, i.e., endplate potential (EPP) were demonstrated as synchronized among the closing muscles. Cooperative work among closing muscles was experimentally indicated.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes


  • Are the claims properly placed in the context of the previous literature?

    NA


  • Do the results support the claims? If not, what other evidence is required?

     Yes


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    Since a healthy volunteer was included in the subjects, it is not necessary to think abou it.


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    NA


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    NA


  • Other Comments:

    In the PDF file we can not see the figures. The author must quickly upload the figures.

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    Nociceptive primary sensory neurons and the effect of capsaicin on them

  • How to cite:  Hiura A .Synchronization Among Endplate Potential Oscillations in Jaw Closing Muscles[Review of the article 'Synchronization Among Endplate Potential Oscillations in Jaw Closing Muscles ' by Kumai T].WebmedCentral 2012;3(11):WMCRW002320
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