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Reviews
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What are the main claims of the paper and how important are they?
It is presented a case report of a patient with Severe Hypothyroidism and Coronary Artery Disease. The coronary arteries and miocardial motion are investigated through CT Coronary Angiography and Hypoperfusion on Contrast Echocardiography.
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Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.
No. The inkages between hypothyroidism and coronary artery disease are investigated by many researchers. It is obvious even in a ordinary cardiology manual.
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Are the claims properly placed in the context of the previous literature?
Yes.
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Do the results support the claims? If not, what other evidence is required?
Yes.
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If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?
A protocol is not presented.
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Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?
The methodology is very brief and could be hardly used for reproducing the results.
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Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?
The presented material can not give any additional information.
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Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?
The paper is a good example for sharing an experince.
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Other Comments:
NA
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Competing interests:
No
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Invited by the author to review this article? :
Yes -
Have you previously published on this or a similar topic?:
Yes
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References:
Many publications on the topic of ischaemic heart disease
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Experience and credentials in the specific area of science:
None - How to cite: Penkov N .Severe Hypothyroidism, Coronary Artery Disease on CT Coronary Angiography and Hypoperfusion on Contrast Echocardiography [Review of the article 'Severe Hypothyroidism, Coronary Artery Disease on CT Coronary Angiography and Hypoperfusion on Contrast Echocardiography ' by Dimova M].WebmedCentral 2012;3(12):WMCRW002372
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What are the main claims of the paper and how important are they?
To study a linkage between hypothyroidism and coronary heart disease.
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Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.
Not novel. Quite a few studies in this area have been performed. Pubmed search will reveal these.
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Are the claims properly placed in the context of the previous literature?
Yes.
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Do the results support the claims? If not, what other evidence is required?
Yes.
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If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?
No details of the protocols and procedures have been described and provided so that the study can be reproduced. This case study just mentions the procedural techniques used in the descussion section.
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Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?
Methodological techniques are valid technologies. However, there is no clear description of the methodology so that other investigators can follow to reproduce it. Video embeded is not very conclusive.
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Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?
NA
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Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?
Not outstanding.
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Other Comments:
NA
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Competing interests:
No.
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
Thyroid Endocrinology
- How to cite: Sarkar P K.Severe Hypothyroidism, Coronary Artery Disease on CT Coronary Angiography and Hypoperfusion on Contrast Echocardiography[Review of the article 'Severe Hypothyroidism, Coronary Artery Disease on CT Coronary Angiography and Hypoperfusion on Contrast Echocardiography ' by Dimova M].WebmedCentral 2012;3(11):WMCRW002359
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The manuscript dealt with a case of hypothiroidism and typical angina on exertion, evaluated by CT Coronary Angiography and Hypoperfusion on Contrast Echocardiography.
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Bari, December, 12th, 2012
Title: “Severe Hypothyroidism, Coronary Artery Disease on CT Coronary Angiography and Hypoperfusion on Contrast Echocardiography”.
Dear Editor,
We have read through this case report and we think that some things should be better outlined:
1. English should be improved by a native English speaker.
2. The abstract conclusions seems to “strong” for a case report. I think they should be deleted or re-phrased.
3. There is a deep concern about this work. It seems quite surprising not to read that the patient had undergone coronary angiography. The patient suffered from “typical angina on exertion”, as outlined by the authors. Why did he not undergo coronary angiography but rather the evaluations stopped to non-invasive technique?
4. Furthermore, we have no idea about the drugs administered to the patient and their dosage. The patient had a severe hypothyroidism and chest pain on exertion: what did physicians do in order to improve such conditions? Please comment.
5. Another ethical problem. The authors wrote: “Three-vessel proximal coronary artery disease was found with diffuse involvement of coronary arteries. (Fig.1)”. Why did the patient not undergo CABG? Did the authors ask a cardiac surgeon opinion? What did he say? Please complete the description.
6. Again, the conclusion of the manuscript are too strong for a case report. Please delete or re-write them.
Yours sincerely,
Dr. Pietro Scicchitano
Address:
Piazza G. Cesare 11 - 70124 Bari Italy
Tel +39-3339801846
e-mail: piero.sc@hotmail.it
None to declare.
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I make researches on non-invasive assessment of cardiovascular diseases, relating them to endocrinological, kydney, gastroenterological, neurological, and many other fields of medicine.