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Submited on: 28 Nov 2011 11:59:33 AM GMT
Published on: 28 Nov 2011 05:22:53 PM GMT
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Other Comments:
Highly interesting publication!
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Competing interests:
No
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
Yes
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References:
Haslberger, A, Varga F,. Karlic H Recursive causality in evolution: A model for epigenetic mechanisms in cancer development. Medical Hypotheses (2006) 67, 1448–1454 Pfeilstöcker M., H. Karlic, T. Nösslinger, W. Sperr, R. Stauder, O. Krieger, P. Valent, (2007) Myelodysplastic syndromes, aging, and age: Correlations, common mechanisms, and clinical implications Leukemia and Lymphoma 2007 48:10, 1900 - 1909 -
Experience and credentials in the specific area of science:
More than 30 years of research experience in cell biology
- How to cite: Karlic H .The benefits of ageing...[Review of the article 'Phylogeny of Age-Related Fitness Decline in the Wild and of Related Phenomena ' by Libertini G].WebmedCentral 2012;3(2):WMCRW001474
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Other Comments:
A good review paper for those studying ageing.
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Competing interests:
no
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Invited by the author to review this article? :
No -
Have you previously published on this or a similar topic?:
No
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References:
None -
Experience and credentials in the specific area of science:
I have been president of Brazilian Society on Ageing Studies
- How to cite: Bedin V .Phylogeny of age-related fitness decline in the wild and of related phenomena[Review of the article 'Phylogeny of Age-Related Fitness Decline in the Wild and of Related Phenomena ' by Libertini G].WebmedCentral 2012;2(12):WMCRW001188
Dear Prof. Bedin,
thank you for your kind review. You may find my contribution on aging phenomenon (in particular on programmed hypothesis of aging) in my personal page www.r-site.org/ageing or in the site www.programmed-aging.org.
My best regards, Giacinto Libertini
Responded by Dr. Giacinto Libertini on 02 Dec 2011 08:41:52 AM
Responded by Dr. Giacinto Libertini on 02 Dec 2011 08:41:52 AM
The paper is a good review of the subject of apoptosis, the role of telomeres and phenoptosis with regards to evolutionary theories of aging
The author has proposed this previously but the approach is novel. The suggestion that kin selection plays an important role is particulalry attractive.
Yes, particularly within the author's sphere of interests
Yes. The evidence provided in the paper is sufficient as an initial support, although it may be necessary to expand the approach in order to encompass other similar or related concepts, as a way of supporting the original claim.
NA
Yes, as a discussion paper, no clinical research is relevant at this stage.
This is a large subject with wide scope, and many of the individual threads can be (and have been) discussed in more detail, in other papers by the author
Yes, this approach is novel and has many repercussions on future treatments of aging.
No
None
No
Yes
Yes
None