Submited on: 28 Nov 2011 11:59:33 AM GMT
Published on: 28 Nov 2011 05:22:53 PM GMT
 
Age-related Fitness Decline
Posted by Dr. Marios Kyriazis on 06 Dec 2012 12:00:56 PM GMT

  • What are the main claims of the paper and how important are they?

    The paper is a good review of the subject of apoptosis, the role of telomeres and phenoptosis with regards to evolutionary theories of aging


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    The author has proposed this previously but the approach is novel. The suggestion that kin selection plays an important role is particulalry attractive.


  • Are the claims properly placed in the context of the previous literature?

    Yes, particularly within the author's sphere of interests


  • Do the results support the claims? If not, what other evidence is required?

    Yes. The evidence provided in the paper is sufficient as an initial support, although it may be necessary to expand the approach in order to encompass other similar or related concepts, as a way of supporting the original claim.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    NA


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes, as a discussion paper, no clinical research is relevant at this stage.


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    This is a large subject with wide scope, and many of the individual threads can be (and have been) discussed in more detail, in other papers by the author


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes, this approach is novel and has many repercussions on future treatments of aging.


  • Other Comments:

    No

  • Competing interests:
    None
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:

    Yes

  • Experience and credentials in the specific area of science:
    None
  • How to cite:  Kyriazis M .Age-related Fitness Decline[Review of the article 'Phylogeny of Age-Related Fitness Decline in the Wild and of Related Phenomena ' by Libertini G].WebmedCentral 2012;3(12):WMCRW002376
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The benefits of ageing...
Posted by Prof. Heidrun Karlic on 09 Feb 2012 11:11:27 AM GMT

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Highly interesting publication!

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    Haslberger, A, Varga F,. Karlic H Recursive causality in evolution: A model for epigenetic mechanisms in cancer development. Medical Hypotheses (2006) 67, 1448–1454 Pfeilstöcker M., H. Karlic, T. Nösslinger, W. Sperr, R. Stauder, O. Krieger, P. Valent, (2007) Myelodysplastic syndromes, aging, and age: Correlations, common mechanisms, and clinical implications Leukemia and Lymphoma 2007 48:10, 1900 - 1909
  • Experience and credentials in the specific area of science:

    More than 30 years of research experience in cell biology

  • How to cite:  Karlic H .The benefits of ageing...[Review of the article 'Phylogeny of Age-Related Fitness Decline in the Wild and of Related Phenomena ' by Libertini G].WebmedCentral 2012;3(2):WMCRW001474
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1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    A good review paper for those studying ageing.

  • Competing interests:
    no
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I have been president of Brazilian Society on Ageing Studies

  • How to cite:  Bedin V .Phylogeny of age-related fitness decline in the wild and of related phenomena[Review of the article 'Phylogeny of Age-Related Fitness Decline in the Wild and of Related Phenomena ' by Libertini G].WebmedCentral 2012;2(12):WMCRW001188
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Dear Prof. Bedin, thank you for your kind review. You may find my contribution on aging phenomenon (in particular on programmed hypothesis of aging) in my personal page www.r-site.org/ageing or in the site www.programmed-aging.org. My best regards, Giacinto Libertini
Responded by Dr. Giacinto Libertini on 02 Dec 2011 08:41:52 AM