Submited on: 12 Feb 2013 11:06:41 AM GMT
Published on: 12 Feb 2013 01:59:23 PM GMT
Review on
Posted by Prof. Kulvinder K Kaur on 25 Feb 2013 06:37:00 AM GMT

  • What are the main claims of the paper and how important are they?

    The authors compare intake of 60,000 unit Vit D in 3ml of oil with or without meals in a very specialized poulation namely 13 general practitioners during winter and spring timeand conclude that Vit D absorption is not significantly affected by fasting/with a fatty meal.However the study design is very weak with authors themselves considering limitations of their own study using a very low dose of VIT D and manufacturer brochure showing a CV of 11.1%for 25-hydroxy vitramin D which corresponds to 36%fasting and 56%increases in 25 oh vit d serum levels one week after dosing.Further very small number of a specialzed population of patients used ie GP'S ans also didnt consider effect of vehicle substances like Grossmann et al showed oily vehicles produced a greater 25(OH)Dresponse than Vit D in a powder or ethanol vehicle.Also since obesity affects Vit D absorption no mention of BMI has been made although it is mentioned height and weights of GP'S were taken but not bothered to consider this criteria.Although authors mention in limitations that they had problems accessing only what was available to local GP'S and 2ndly they didnt get an ethical commitee permission.

  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    No rather claims cant be concluded by small cohort1)Dawson-Hughes B,Harris SS,Palermo NJ,Ceglia L,Rasmussen H.Meal conditions affect the absorption of supplemental vitamin D(3)but not the plasma 25-hydroxyvitaminD response to supplementation.J Bone Miner Res 2013 feb 20 Epub ahead of print2)Vavricka SR,Rogler G.Intestinal absorption and vitamin levels:is a new focus needed?Dig Dis 2012;30Suppl 3:73-80.3)Grossmann RE,Tangpricha V.Evaluation of vehicle substances on vitamin D bioavailability:A Systematic review.Mol Nutr Food Res 2010;54:1055-1061.4)Li T,Chiang JY.Nuclear receptors in bile acid metabolism.Drug Metab Rev 2013;45:145-155.50Sibilska IK,Szybinski M,Sicinski RR,Plum LA,Deluca HF.Highly potent 2-methylene analogues of 1alpha,25-dihydroxyvitamin D(3):Synthesis and biological evaluation.JSteroid Biochem MolBiol 2013;feb 11 Epub ahead of print

  • Are the claims properly placed in the context of the previous literature?

    To make an inference from such a small size of cases analyzed and that too wothout any other factors affecting outcome like vehicle &a huge cv it is impossible to come to a conclusion&nit having ethical clearance further hinders any further testing to improve-although they can try improving checking in different BMI gp's OF BOTH SEXES in the same months when lattitude effects are observed to see the effect of supplementation but with recent studies concentrating on better molecules with greater potency by making analogs of 1,25 dihydroxy vitamin D3 observing effects of various vehicles like oil and lactose powder having sifferent affects on micelle formation and powder vehicles on protein transporters respectively,there is not much point in trying to define whether with or without fat VIT D should be taken,Also levels of 25hydroxy vit D depend on baseline if

  • Do the results support the claims? If not, what other evidence is required?

    The author himself has provided the limitations and the reasons.

  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No-very scanty number of patients and out of that also 1 patients results deducted.Need a larger number of patients/poulation to be studied to draw any conclusions.and further all parameters not considered like vehicle,BMI,sex difference,baseline values

  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Difficullt as no Ethical Clearance and need clearance from swiss medic drug authority  to be able to procure proper preparations and proper representative population to be studied in greater numbers to get over the CV bias of 11% FOR 25OH VIT D

  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Work is being done on CYP24 hydroxylase inhibitirs like CYP24A1 inhibitirs selective targets gfor novel VIT D compounds of therapeitic value with 2 novel side chain modified 2mrthylene--19.nor-1,25(OH)2D3 analogues -22imidazole-1-yl derivative2(VIMI) and the 25-N-cyclopropylamine compiund3(CPA1)-wITH IMP FUNCTIOS OF VIT D IN BONE and mineral function and disadvantage of hyopercalcemia with conventional vitdoverdosage imp to consider these newer compounds with lot of important functions for vit d in hypertension,multiple scvlerosis,colon cancer,muscle strength with vit d receptors in muscle and role in obesity ,dm etc im p to consider newer analogues.

  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?


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  • Have you previously published on this or a similar topic?:
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  • Experience and credentials in the specific area of science:

    Being a reproductive endocrinologist encountered all types of infertile and pregnant patients and postmenopausal patients with vit d deficiency and manage for donor ova very old patients besides avoiding stress fractures in them.

  • How to cite:  Kaur K K.Review on [Review of the article 'Oral vitamin D - Is it Necessary to be taken with Meals Containing Fat? ' by Zeller M].WebmedCentral 2013;4(2):WMCRW002533
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