Submited on: 06 Oct 2013 04:18:38 PM GMT
Published on: 07 Oct 2013 07:06:12 AM GMT
 
DNAzyme mediated post-transcriptional gene silencing: A novel therapeutic approach
Posted by Dr. Juliano S Toledo on 31 Oct 2013 10:40:23 AM GMT Reviewed by WMC Editors

  • What are the main claims of the paper and how important are they?

    It is not applicable, it is a review.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    It is not applicable, it is a review.


  • Are the claims properly placed in the context of the previous literature?

    It is not applicable, it is a review.


  • Do the results support the claims? If not, what other evidence is required?

    It is not applicable, it is a review.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    It is not applicable, it is a review.


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    It is not applicable, it is a review.


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    It is not applicable, it is a review.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes. This issue is very interesting, but this review needs to be revised and enlarged with more in-depth review of the literature.


  • Other Comments:

    1. The English grammar needs to be revised.
    2. There are some typographical errors across the text.
    3. Copying and pasting was detected.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I am molecular biologist with experience in gene expression control of Leishmania.

  • How to cite:  Toledo J S.DNAzyme mediated post-transcriptional gene silencing: A novel therapeutic approach[Review of the article 'DNAzyme mediated post-transcriptional gene silencing: A novel therapeutic approach ' by Chauhan S].WebmedCentral 2013;4(10):WMCRW002885
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DNAzyme mediated post-transcriptional gene silencing: A novel therapeutic approach
Posted by Dr. Inamul Haque on 24 Oct 2013 05:37:44 PM GMT Reviewed by WMC Editors

  • What are the main claims of the paper and how important are they?

    Not applicable - the paper is a review article about DNAzyme.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Not applicable - the paper is a review article.


  • Are the claims properly placed in the context of the previous literature?

    Not applicable - the paper is a review article.


  • Do the results support the claims? If not, what other evidence is required?

    Not applicable - the paper is a review article.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    Not applicable - the paper is a review article.


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Not applicable - the paper is a review article.


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Not applicable - the paper is a review article.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    No. But it has the potential if revised, focused, and more in-depth review of the literature.


  • Other Comments:

    i) Needs to be proof-read, not the best English grammar and flow.
    ii) Typographical errors are extensive.
    iii) Copying and pasting was found at several places in the text.

    Overall, the writing, clarity, and presentation are reasonable and did not influence the review.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I have extensive works on biochemistry and molecular biology especially cancer biology.

  • How to cite:  Haque I .DNAzyme mediated post-transcriptional gene silencing: A novel therapeutic approach[Review of the article 'DNAzyme mediated post-transcriptional gene silencing: A novel therapeutic approach ' by Chauhan S].WebmedCentral 2013;4(10):WMCRW002878
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