Submited on: 28 Nov 2011 02:37:11 PM GMT
Published on: 29 Nov 2011 04:52:30 PM GMT
 
Immunogenetics and Demographic Health Issues
Posted by Dr. William J Maloney on 14 Feb 2014 10:38:06 PM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    The main purpose of this paper is to demonstrate that the genotyping of immune-related genes and the recording of their frequencies in the local populations provide clues to upkeep their role in the survival advantage of homo sapiens.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Yes


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    Yes


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    No


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    Yes- it would be a great lecture at a medical school.


  • Other Comments:

    The authors state that variation among individuals of human population lies at different levels.  We are endowed with the potential for innate and adaptive immunity due to evolution.  The evolutionary selection pressure invested humans with a variety of immune-related genes.

  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    clinical associate professor

  • How to cite:  Maloney W J.Immunogenetics and Demographic Health Issues[Review of the article 'Lessons from Immunogenetics Unfold Inherent Demographic Health Issues ' by Sreerama K].WebmedCentral 2014;5(2):WMCRW002996
1 2 3 4 5 6 7 8 9
Report abuse
 

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    This is an excellent summary and analysis of the role of host genetics in evolution and disease. The review is insightful, thorough and well written.

  • Competing interests:
    None
  • Invited by the author to review this article? :
    Yes
  • Have you previously published on this or a similar topic?:
    No
  • References:
    None
  • Experience and credentials in the specific area of science:

    I am interested in the role of host genetics in the genetic diversity and evolution of HIV and have recently initiated research in this field. 

  • How to cite:  Hewlett I .Lessons from Immunogenetics Unfold Inherent Demographic Health Issues[Review of the article 'Lessons from Immunogenetics Unfold Inherent Demographic Health Issues ' by Sreerama K].WebmedCentral 2014;3(1):WMCRW001332
1 2 3 4 5 6 7 8 9
Report abuse
 

1 Is the subject of the article within the scope of the subject category? Yes
2 Are the interpretations / conclusions sound and justified by the data? Yes
3 Is this a new and original contribution? Yes
4 Does this paper exemplify an awareness of other research on the topic? Yes
5 Are structure and length satisfactory? Yes
6 Can you suggest brief additions or amendments or an introductory statement that will increase the value of this paper for an international audience? No
7 Can you suggest any reductions in the paper, or deletions of parts? No
8 Is the quality of the diction satisfactory? Yes
9 Are the illustrations and tables necessary and acceptable? Yes
10 Are the references adequate and are they all necessary? Yes
11 Are the keywords and abstract or summary informative? Yes
  • Other Comments:

    Congratulations, it's an excellent review on the subject.

  • Competing interests:
    No
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    Yes
  • References:
    1. Guadalupe Garcia-Elorriaga, Guadalupe Carrillo-Montes, Melby Mendoza-Aguilar and Cesar Gonzalez-Bonilla. Polymorphisms in Tumor Necrosis Factor and lymphotoxin a in Tuberculosis and Without Response to Treatment with. Inflammation. 2010, 33 (4) :267-275. 2. Tumor necrosis factor (TNF) -308 and lymphotoxin (LTA) +252 polymorphisms in Kawasaki disease Children with coronary aneurysms and in Mexico. Francisco Cruz-Olivo, Guadalupe Garcia-Elorriaga, Cesar Gonzalez-Bonilla, Guillermo del Rey-Pineda, and Javier Mancilla-Ramirez. In press, Arch Med Res.
  • Experience and credentials in the specific area of science:

    I worked on the subject of SNP's for 6 years. TNF and IL-10 SNP's. 


  • How to cite:  Garcia G .Lessons from Immunogenetics Unfold Inherent Demographic health Issues.[Review of the article 'Lessons from Immunogenetics Unfold Inherent Demographic Health Issues ' by Sreerama K].WebmedCentral 2014;2(11):WMCRW001176
1 2 3 4 5 6 7 8 9
Report abuse