Submited on: 02 Nov 2015 03:50:23 PM GMT
Published on: 04 Nov 2015 11:40:25 AM GMT
 
2 NMEs for Treatment of Atherosclerosis
Posted by Ms. Madison Williams on 19 Dec 2016 05:16:58 PM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    The main claim is that 2 NMEs, when combined together, are able to reduce cholesterol, triglycerides, and atherosclerosis.


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    This is one of a series of papers by this research group that demonstrate such an effect in different animal models and for different periods of time.


  • Are the claims properly placed in the context of the previous literature?

    Yes, an extensive review of related literature is provided. A previous study demonstrated the same effect over a period of eight weeks. This study shows that the effect extends out to 16 weeks.


  • Do the results support the claims? If not, what other evidence is required?

    The data show a reduction in body weight gain, fat pad mass, total serum cholesterol, serum triglycerides, and atherosclerotic lesion area in mice on a Western diet.


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    No protocol deviations were reported.


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Sufficient details are provided to reproduce the study.


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    It might be interesting to include separate D tagatose and polydatin treatment groups for comparison. Of course, these are provided in other publications, some by these authors and some by others, and it would increase the expense of the study.


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    The results of a human clinical trial would be interesting.


  • Other Comments:

    n/a

  • Competing interests:
    .
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:

    No.

  • Experience and credentials in the specific area of science:

    Yes.

  • How to cite:  Williams M .2 NMEs for Treatment of Atherosclerosis[Review of the article 'BSN272 Prevents Western Diet-Induced Atherosclerosis and Excess Weight Gain in ApoE/Mice ' by Banfield A].WebmedCentral 2015;7(12):WMCRW003351
1 2 3 4 5 6 7 8 9
Report abuse
 
BSN272 Prevents Western Diet-Induced Atherosclerosis and Excess Weight Gain in ApoE/Mice.
Posted by Dr. Shakila Srikumar on 07 Nov 2015 10:36:49 AM GMT Reviewed by Interested Peers

  • What are the main claims of the paper and how important are they?

    The paper claims the value of the modified diet BSN272 over the western diet 

    the claim seems valid in this comparative study


  • Are these claims novel? If not, please specify papers that weaken the claims to the originality of this one.

    Not novel. However, the novelty of this paper is only in the context of using of ApoE-/- mice instead of Low-density lipoprotein receptor deficient (LDLr−/−) mice 


  • Are the claims properly placed in the context of the previous literature?

    Yes


  • Do the results support the claims? If not, what other evidence is required?

    Duplication of the results required and the number is low


  • If a protocol is provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?

    Not applicable 


  • Is the methodology valid? Does the paper offer enough details of its methodology that its experiments or its analyses could be reproduced?

    Yes adequate details of methodology provided


  • Would any other experiments or additional information improve the paper? How much better would the paper be if this extra work was done, and how difficult would such work be to do, or to provide?

    Clinical trials would validate the claims


  • Is this paper outstanding in its discipline? (For example, would you like to see this work presented in a seminar at your hospital or university? Do you feel these results need to be incorporated in your next general lecture on the subject?) If yes, what makes it outstanding? If not, why not?

    No 


  • Other Comments:

    Can be published

  • Competing interests:
    .
  • Invited by the author to review this article? :
    No
  • Have you previously published on this or a similar topic?:
    No
  • References:

    .

  • Experience and credentials in the specific area of science:

    .

  • How to cite:  Srikumar S .BSN272 Prevents Western Diet-Induced Atherosclerosis and Excess Weight Gain in ApoE/Mice.[Review of the article 'BSN272 Prevents Western Diet-Induced Atherosclerosis and Excess Weight Gain in ApoE/Mice ' by Banfield A].WebmedCentral 2015;6(11):WMCRW003256
1 2 3 4 5 6 7 8 9
Report abuse